{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T15:40:25Z","timestamp":1768318825790,"version":"3.49.0"},"reference-count":114,"publisher":"Informa UK Limited","issue":"2","funder":[{"name":"No funding"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1080\/13543784.2024.2311207","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T09:40:17Z","timestamp":1706521217000},"page":"115-126","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["Novel agents to treat adrenal insufficiency: findings of preclinical and early clinical trials"],"prefix":"10.1080","volume":"33","author":[{"given":"Andrew","family":"Peel","sequence":"first","affiliation":[{"name":"Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. Louise","family":"Rushworth","sequence":"additional","affiliation":[{"name":"School of Medicine, Sydney, The University of Notre Dame, Australia, Sydney, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David J","family":"Torpy","sequence":"additional","affiliation":[{"name":"Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2024,2,5]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2017.10.010"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvad017"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-021-02649-6"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12991"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.20945\/2359-3997000000392"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1548869"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1395680"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3691913"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2020.01.029"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23168984"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00020.2012"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2015.08.002"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01545"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.06314"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030440"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13837"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-72-1-39"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2017.02.005"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-6915(02)00209-0"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c140003"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.09.009"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5488.2344"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/js.2018-00021"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13217"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000442985"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2021.07.003"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1710"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2018-0824"},{"issue":"3","key":"e_1_3_4_31_1","first-page":"259","article-title":"Serum cortisol levels via radioimmunoassay vs liquid chromatography mass spectrophotometry in healthy control subjects and patients with adrenal incidentalomas","volume":"49","author":"Huayllas MKP","year":"2018","unstructured":"Huayllas MKP, Netzel BC, Singh RJ, et al. Serum cortisol levels via radioimmunoassay vs liquid chromatography mass spectrophotometry in healthy control subjects and patients with adrenal incidentalomas. Lab Med. 2018 Jul 5;49(3):259\u2013267.","journal-title":"Lab Med"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eprac.2022.04.003"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2016-0400"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/med.0000000000000806"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004563216687335"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-021-02621-4"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2018.09.010"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)74790-X"},{"issue":"2","key":"e_1_3_4_39_1","first-page":"91","article-title":"Hormone of the adrenal cortex","volume":"29","author":"Kendall EC","year":"1953","unstructured":"Kendall EC. Hormone of the adrenal cortex. Bull N Y Acad Med. 1953 Feb;29(2):91\u2013100. PubMed PMID: 13009391. PubMed Central; PMCID: PMCPMC1877288. eng","journal-title":"Bull N Y Acad Med"},{"issue":"8","key":"e_1_3_4_40_1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0025-6196(24)00526-3","article-title":"The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone; compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis","volume":"24","author":"Hench PS","year":"1949","unstructured":"Hench PS, Kendall EC, Slocumb CH, et al. The effect of a hormone of the adrenal cortex (17-hydroxy-11-dehydrocorticosterone; compound E) and of pituitary adrenocorticotropic hormone on rheumatoid arthritis. Proc Staff Meetings Mayo Clin. 1949 Apr 13;24(8):181\u2013197. PubMed PMID: 18118071; eng","journal-title":"Proc Staff Meetings Mayo Clin"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rdc.2015.08.001"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci101185"},{"issue":"5","key":"e_1_3_4_43_1","first-page":"S-5","article-title":"History of the development of corticosteroid therapy","volume":"29","author":"Benedek TG","year":"2011","unstructured":"Benedek TG. History of the development of corticosteroid therapy. Clin Exp Rheumatol. 2011 Sep-Oct;29(5 Suppl 68):S-5\u201312. PubMed PMID: 22018177; eng","journal-title":"Clin Exp Rheumatol"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-200544010-00003"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1984.tb04999.x"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje-17-0154"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2018.04.015"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab096"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje-08-0550"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-016-1204-2"},{"key":"e_1_3_4_51_1","first-page":"100256","article-title":"Evaluation of FKBP5 as a cortisol activity biomarker in patients with ACTH-dependent Cushing syndrome","volume":"24","author":"Bancos I","year":"2021","unstructured":"Bancos I, Hatipoglu BA, Yuen KCJ, et al. Evaluation of FKBP5 as a cortisol activity biomarker in patients with ACTH-dependent Cushing syndrome. J Clin Transl Endocrinol. 2021 Mar;24:100256.","journal-title":"J Clin Transl Endocrinol"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje-15-0964"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvaa202"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62236"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02544.x"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-07-0052"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12670"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-2433"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-4253"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1916"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-2092-5228"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10484-009-9082-5"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/5315059"},{"key":"e_1_3_4_64_1","first-page":"150005","article-title":"Management of adrenocortical insufficiency with continuous subcutaneous hydrocortisone infusion: long-term experience in three patients","volume":"2015","author":"Khanna A","year":"2015","unstructured":"Khanna A, Khurana R, Kyriacou A, et al. Management of adrenocortical insufficiency with continuous subcutaneous hydrocortisone infusion: long-term experience in three patients. Endocrinol Diabetes Metab Case Rep. 2015;2015:150005. PubMed PMID: 26124953; PubMed Central PMCID: PMCPMC4482159. eng","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13813"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0630"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-018-1780-4"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.5402\/2011\/219494"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2014-0473"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1515\/jpem.2011.226"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adg8464"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.03011.x"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2380"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje-16-0948"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12316"},{"key":"e_1_3_4_76_1","unstructured":"Clinicaltrials.gov. Chronocort versus plenadren replacement therapy in adults with adrenal insufficiency. [cited 2023 Dec 30]. Available from: https:\/\/ClinicalTrials.gov\/show\/NCT05222152"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2009.03636.x"},{"issue":"6","key":"e_1_3_4_78_1","first-page":"1797","article-title":"Modified-release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia","volume":"102","author":"Jones CM","year":"2017","unstructured":"Jones CM, Mallappa A, Reisch N, et al. Modified-release and conventional glucocorticoids and diurnal androgen excretion in congenital adrenal hyperplasia. J Clin Endocrinol Metab. 2017 Jun 1;102(6):1797\u20131806.","journal-title":"J Clin Endocrinol Metab"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2014-3809"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgab051"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejendo\/lvac006"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje-09-0170"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje-15-1212"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.1530\/ec-20-0473"},{"key":"e_1_3_4_85_1","unstructured":"Hydrocortisone Vs Prednisolone in AI (HYPER-AID). [cited 2023 Dec 30]. Available from: https:\/\/classic.clinicaltrials.gov\/show\/NCT03608943."},{"key":"e_1_3_4_86_1","unstructured":"Safety and efficacy of prednisolone in adrenal insufficiency disease (PRED-AID Study). [cited 2023 December 30]. Available from: https:\/\/classic.clinicaltrials.gov\/show\/NCT03936517."},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1926"},{"key":"e_1_3_4_88_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad370"},{"key":"e_1_3_4_89_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-18-0257"},{"key":"e_1_3_4_90_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa862"},{"key":"e_1_3_4_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-015-0681-z"},{"key":"e_1_3_4_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2213-8587(17)30398-4"},{"key":"e_1_3_4_93_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje-17-0067"},{"key":"e_1_3_4_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-13506-5"},{"key":"e_1_3_4_95_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.610904"},{"key":"e_1_3_4_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-022-01940-1"},{"key":"e_1_3_4_97_1","doi-asserted-by":"publisher","DOI":"10.1177\/2042018819871169"},{"key":"e_1_3_4_98_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje-14-1114"},{"key":"e_1_3_4_99_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13554"},{"key":"e_1_3_4_100_1","doi-asserted-by":"publisher","DOI":"10.1530\/EC-19-0176"},{"key":"e_1_3_4_101_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje-20-0642"},{"key":"e_1_3_4_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1093838"},{"key":"e_1_3_4_103_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.641247"},{"key":"e_1_3_4_104_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-020-02458-3"},{"key":"e_1_3_4_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2014.08.008"},{"key":"e_1_3_4_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-022-01889-1"},{"key":"e_1_3_4_107_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1512-1"},{"key":"e_1_3_4_108_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvad151"},{"key":"e_1_3_4_109_1","doi-asserted-by":"publisher","DOI":"10.1530\/ec-17-0368"},{"key":"e_1_3_4_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-020-02507-x"},{"key":"e_1_3_4_111_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1807486"},{"key":"e_1_3_4_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2018.03.004"},{"key":"e_1_3_4_113_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnad016"},{"key":"e_1_3_4_114_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1908264116"},{"key":"e_1_3_4_115_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2018-000889"},{"key":"e_1_3_4_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115145"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2024.2311207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,9]],"date-time":"2024-11-09T11:26:04Z","timestamp":1731151564000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2024.2311207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":114,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1080\/13543784.2024.2311207"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2024.2311207","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-11-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}