{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T21:50:50Z","timestamp":1793397050139,"version":"4.5.0"},"reference-count":17,"publisher":"Informa UK Limited","issue":"10","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31371399"],"award-info":[{"award-number":["31371399"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2024,10,2]]},"DOI":"10.1080\/13543784.2024.2391837","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T18:38:40Z","timestamp":1724265520000},"page":"1075-1082","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["The first-in-human study to assess the safety, tolerability, pharmacokinetics, and pharmacodynamics of the factor XI monoclonal antibody SHR-2004 in healthy subjects"],"prefix":"10.1080","volume":"33","author":[{"given":"Tingting","family":"Ma","sequence":"first","affiliation":[{"name":"Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuyi","family":"Weng","sequence":"additional","affiliation":[{"name":"Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Cao","sequence":"additional","affiliation":[{"name":"Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Dong","sequence":"additional","affiliation":[{"name":"Clinical Research &amp; Development, Jiangsu Hengrui Pharmaceuticals Co., Ltd., Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanjuan","family":"Deng","sequence":"additional","affiliation":[{"name":"Clinical Research &amp; Development, Jiangsu Hengrui Pharmaceuticals Co., Ltd., Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[{"name":"Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanxun","family":"Yang","sequence":"additional","affiliation":[{"name":"Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Clinical Research &amp; Development, Jiangsu Hengrui Pharmaceuticals Co., Ltd., Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Shen","sequence":"additional","affiliation":[{"name":"Protein biology department, Beijing TUO JIE Biopharmaceutical Co. Ltd., Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Wang","sequence":"additional","affiliation":[{"name":"Protein biology department, Beijing TUO JIE Biopharmaceutical Co. Ltd., Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Shen","sequence":"additional","affiliation":[{"name":"Clinical Research &amp; Development, Jiangsu Hengrui Pharmaceuticals Co., Ltd., Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Phase I Clinical Trials Unit, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"e_1_3_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61728-0"},{"key":"e_1_3_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.01.072"},{"key":"e_1_3_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-2667(21)00228-0"},{"key":"e_1_3_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62343-0"},{"key":"e_1_3_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2021.06.010"},{"key":"e_1_3_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2014.03.020"},{"key":"e_1_3_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-199182"},{"key":"e_1_3_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2017.10.008"},{"key":"e_1_3_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2021.07.012"},{"key":"e_1_3_8_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-09-742262"},{"key":"e_1_3_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/rth2.12186"},{"key":"e_1_3_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rpth.2023.100067"},{"key":"e_1_3_8_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.20687"},{"key":"e_1_3_8_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011725"},{"key":"e_1_3_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15577"},{"key":"e_1_3_8_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.312328"},{"key":"e_1_3_8_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.15744"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2024.2391837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,22]],"date-time":"2024-10-22T01:05:21Z","timestamp":1729559121000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2024.2391837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":17,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10,2]]}},"alternative-id":["10.1080\/13543784.2024.2391837"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2024.2391837","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,22]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}