{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T15:32:26Z","timestamp":1781623946868,"version":"3.54.5"},"reference-count":37,"publisher":"Informa UK Limited","issue":"1-2","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1080\/13543784.2025.2463093","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T13:53:06Z","timestamp":1738936386000},"page":"27-36","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":7,"title":["Early investigational agents for the treatment of rosacea: drugs in phase I and II clinical development"],"prefix":"10.1080","volume":"34","author":[{"given":"Shannon K.","family":"Moran","sequence":"first","affiliation":[{"name":"Wake Forest University School of Medicine","place":["Winston-Salem, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Summer C.","family":"Wong","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine","place":["Winston-Salem, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine","place":["Winston-Salem, USA"]},{"name":"Wake Forest University School of Medicine","place":["Winston-Salem, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven R.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Wake Forest University School of Medicine","place":["Winston-Salem, USA"]},{"name":"Wake Forest University School of Medicine","place":["Winston-Salem, USA"]},{"name":"Wake Forest University School of Medicine","place":["Winston-Salem, USA"]},{"name":"Wake Forest University School of Medicine","place":["Winston-Salem, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,2,9]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.14816"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.16815"},{"issue":"6","key":"e_1_3_4_5_1","first-page":"348","article-title":"Burden of disease: the psychosocial impact of rosacea on a patient\u2019s quality of life","volume":"6","author":"Huynh TT.","year":"2013","unstructured":"Huynh TT. Burden of disease: the psychosocial impact of rosacea on a patient\u2019s quality of life. Am Health Drug Benefits. 2013 Jul;6(6):348\u2013354.","journal-title":"Am Health Drug Benefits"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11082153"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.3c00324"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2017.1370370"},{"key":"e_1_3_4_9_1","unstructured":"Accessdata.fda.gov [Internet]. Label for roflumilast cream 0.3%. U.S. Food and Drug Administration; Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2020\/213690s000lbl.pdf"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ski2.346"},{"issue":"8","key":"e_1_3_4_11_1","first-page":"19","article-title":"Effect of topical microencapsulated benzoyl peroxide on the skin microbiome in rosacea: a randomized, double-blind, crossover, vehicle-controlled clinical trial","volume":"17","author":"Nong Y","year":"2024","unstructured":"Nong Y, Sugarman J, York JP, et al. Effect of topical microencapsulated benzoyl peroxide on the skin microbiome in rosacea: a randomized, double-blind, crossover, vehicle-controlled clinical trial. J Clin Aesthet Dermatol. 2024 Aug;17(8):19\u201326","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abd.2019.12.002"},{"key":"e_1_3_4_13_1","unstructured":"ClinicalTrials.gov [Internet]. Evaluating use of topical imipramine and amitriptyline in reducing ultraviolet b light-induced redness in patients with rosacea. (MD): National Library of Medicine; 2024 [cited 2024 Aug 10]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT06312813"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.03.030"},{"key":"e_1_3_4_15_1","unstructured":"ClinicalTrials.gov [Internet]. Evaluation of the safety and efficacy of topical roflumilast cream in the treatment of facial papulopustular rosacea. (MD): National Library of Medicine; 2023 [cited 2024 Aug 10]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT05278624?a=1"},{"key":"e_1_3_4_16_1","unstructured":"ClinicalTrials.gov [Internet]. PDE4 Inhibition in seborrheic dermatitis and papulopustular rosacea. (MD): National library of medicine; 2023 [updated 2024 Jul 12; cited 2024 Aug 10]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT06013371"},{"key":"e_1_3_4_17_1","unstructured":"ClinicalTrials.gov [Internet]. Maryland: National Library of Medicine; efficacy and tolerability of erenumab in the management of persistent redness and flushing in rosacea (STOP ros). 2020 [updated 2020 Jun 11; cited 2024 Aug 10]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT04419259?term=NCT04419259&rank=1"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamadermatol.2024.0408"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2016.01.059"},{"key":"e_1_3_4_20_1","unstructured":"ClinicalTrials.gov [Internet]. Safety efficacy and pharmacokinetics of rifaximin in patients with moderate-to-severe papulopustular rosacea. (MD): National Library of Medicine; 2024 [updated 2024 Apr 24; cited 2024 Dec 20]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT05150587?cond=rosacea&limit=100&sort=StudyFirstPostDate&rank=31"},{"key":"e_1_3_4_21_1","unstructured":"ClinicalTrials.gov [Internet]. Maryland: National Library of Medicine; potassium-titanyl phosphate (KTP) laser vs KTP laser and ivermectin cream for facial rosacea (KIR). 2023 [updated 2024 May 22; cited 2024 Aug 10]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT06033352?term=NCT06033352&rank=1"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14030557"},{"key":"e_1_3_4_23_1","unstructured":"ClinicalTrials.gov [Internet]. Maryland: National Library of Medicine; clinical trial to evaluate the effect of a probiotic mixture on the rosacea evolution. 2023 [updated 2024 Jun 28; cited 2024 Aug 10]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT05815511"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/5596030"},{"key":"e_1_3_4_25_1","unstructured":"ClinicalTrials.gov [Internet]. (MD): National Library of Medicine; Metronidazole SC Penetrance With Moisturizers; 2024 [cited 2024 Aug 10]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT06434519"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.36849\/JDD.8510"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16372"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2024.07.771"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16611"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16339"},{"key":"e_1_3_4_31_1","unstructured":"ClinicalTrials.gov [Internet]. Maryland: National Library of Medicine; effects of oral supplement containing L-Histidine and antioxidants on the skin barrier function and systemic inflammation in rosacea. 2023 [updated 27 Aug 2024; cited 2024 Dec 20]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT06072066?cond=rosacea&limit=100&sort=StudyFirstPostDate&rank=11&tab=table"},{"key":"e_1_3_4_32_1","unstructured":"ClinicalTrials.gov [Internet]. Potassium titanyl phosphate laser versus pulsed dye laser for rosacea - a prospective study. (MD): National Library of Medicine; 2023 [cited 2024 Aug 10]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT05771298"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.16300"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-024-04098-9"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14584"},{"key":"e_1_3_4_36_1","unstructured":"ClinicalTrials.gov [Internet]. Rosacea treatment using non-thermal (cold) atmospheric plasma device. (MD): National library of medicine; 2022 [updated 04 Dec 2024; cited 2024 Dec 20]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT05592548?cond=rosacea&limit=100&sort=StudyFirstPostDate&rank=23"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1407871"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S307013"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2021.100882"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2025.2463093","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T07:26:45Z","timestamp":1739863605000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2025.2463093"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":37,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1080\/13543784.2025.2463093"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2025.2463093","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}