{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T14:42:13Z","timestamp":1778337733312,"version":"3.51.4"},"reference-count":132,"publisher":"Informa UK Limited","issue":"4","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2025,4,3]]},"DOI":"10.1080\/13543784.2025.2500288","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T07:25:40Z","timestamp":1746170740000},"page":"267-285","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["Chronic lymphocytic leukemia: what clinical progress have we seen in the last five years?"],"prefix":"10.1080","volume":"34","author":[{"given":"El\u017cbieta","family":"Iskierka-Ja\u017cd\u017cewska","sequence":"first","affiliation":[{"name":"Medical University of Lodz","place":["Lodz, Poland"]},{"name":"Copernicus Memorial Hospital","place":["Lodz, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bartosz","family":"Pu\u0142a","sequence":"additional","affiliation":[{"name":"Medical University of Lodz","place":["Lodz, Poland"]},{"name":"Copernicus Memorial Hospital","place":["Lodz, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Krzysztof","family":"Jamroziak","sequence":"additional","affiliation":[{"name":"Medical University of Warsaw","place":["Warsaw, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3411-6357","authenticated-orcid":false,"given":"Tadeusz","family":"Robak","sequence":"additional","affiliation":[{"name":"Medical University of Lodz","place":["Lodz, Poland"]},{"name":"Copernicus Memorial Hospital","place":["Lodz, Poland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2025,5,3]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-09-806398"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.09.019"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21357"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15184427"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26367"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2020.1770225"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400376"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509388"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1713976"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00741.x"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000845556.79615.3f"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-021-01485-x"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01210"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO-24-02265"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.259432"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2211582"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2300696"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-01-328484"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1812836"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2021.279012"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1817073"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25638"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021006434"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000840"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-10-742437"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0463"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.242909"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1446"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022018818"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2020.08.017"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.70259"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2018030007"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2020009617"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019003715"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.272500"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1130595"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019001160"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-023-05486-x"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(21)00307-0"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00884-4"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17994"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41408-022-00721-6"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.182907"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2023.2236547"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-146491"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2015-08-664086"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/HS9.0000000000000692"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2024.2333985"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2020.1797482"},{"key":"e_1_3_5_52_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2019-127674"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.3164_163"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400029"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11589"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-163596"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.2147\/JEP.S265284"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023012360"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008447"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-022-00315-9"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-23-0670"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2114110"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022008325"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-06-719294"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.156.7.2624"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.34.7898"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-688796"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30019-5"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/hem3.146"},{"key":"e_1_3_5_70_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1815281"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1056\/EVIDoa2200006"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014488"},{"key":"e_1_3_5_73_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.00807"},{"key":"e_1_3_5_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(23)00144-4"},{"key":"e_1_3_5_75_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-201076"},{"key":"e_1_3_5_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.19902"},{"key":"e_1_3_5_77_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2213093"},{"key":"e_1_3_5_78_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024631"},{"key":"e_1_3_5_79_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2809"},{"key":"e_1_3_5_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.32"},{"key":"e_1_3_5_81_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-3934"},{"key":"e_1_3_5_82_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2021.1649"},{"key":"e_1_3_5_83_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2310063"},{"key":"e_1_3_5_84_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-039168"},{"key":"e_1_3_5_85_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-200701"},{"key":"e_1_3_5_86_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-199175"},{"key":"e_1_3_5_87_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-18-1119"},{"key":"e_1_3_5_88_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00027"},{"key":"e_1_3_5_89_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-169662"},{"key":"e_1_3_5_90_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-179541"},{"key":"e_1_3_5_91_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-22-3321"},{"key":"e_1_3_5_92_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2024.01.001"},{"key":"e_1_3_5_93_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011895"},{"key":"e_1_3_5_94_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-167868"},{"key":"e_1_3_5_95_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.19.03237"},{"key":"e_1_3_5_96_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000972484.02679.4e"},{"key":"e_1_3_5_97_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-182896"},{"key":"e_1_3_5_98_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019002936"},{"key":"e_1_3_5_99_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2022007317"},{"key":"e_1_3_5_100_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02392-7"},{"key":"e_1_3_5_101_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2021-146563"},{"key":"e_1_3_5_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.247"},{"key":"e_1_3_5_103_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.72.8519"},{"key":"e_1_3_5_104_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.HS9.0000969368.47239.5b"},{"key":"e_1_3_5_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01052-8"},{"key":"e_1_3_5_106_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.56.2025"},{"key":"e_1_3_5_107_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.01467"},{"key":"e_1_3_5_108_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac5415"},{"key":"e_1_3_5_109_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-189321"},{"key":"e_1_3_5_110_1","doi-asserted-by":"publisher","DOI":"10.4084\/MJHID.2024.045"},{"key":"e_1_3_5_111_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-1081-3"},{"key":"e_1_3_5_112_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111470"},{"key":"e_1_3_5_113_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-169658"},{"key":"e_1_3_5_114_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021014760"},{"key":"e_1_3_5_115_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005872"},{"key":"e_1_3_5_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01758-z"},{"key":"e_1_3_5_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-024-02317-4"},{"key":"e_1_3_5_118_1","doi-asserted-by":"publisher","DOI":"10.1177\/20406207231173489"},{"key":"e_1_3_5_119_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-199116"},{"key":"e_1_3_5_120_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2024-194839"},{"key":"e_1_3_5_121_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-179872"},{"key":"e_1_3_5_122_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-180109"},{"key":"e_1_3_5_123_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V106.11.2976.2976"},{"key":"e_1_3_5_124_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-167153"},{"key":"e_1_3_5_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-022-01758-z"},{"key":"e_1_3_5_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/hon.3163_88"},{"key":"e_1_3_5_127_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-181671"},{"key":"e_1_3_5_128_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2022-169658"},{"key":"e_1_3_5_129_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-3815"},{"key":"e_1_3_5_130_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005083"},{"key":"e_1_3_5_131_1","doi-asserted-by":"publisher","DOI":"10.5603\/AHP.a2022.0013"},{"key":"e_1_3_5_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2017.06.007"},{"key":"e_1_3_5_133_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-023-01955-z"},{"key":"e_1_3_5_134_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-2485"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2025.2500288","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T12:46:38Z","timestamp":1756471598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2025.2500288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,3]]},"references-count":132,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,3]]}},"alternative-id":["10.1080\/13543784.2025.2500288"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2025.2500288","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,3]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}