{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T18:03:13Z","timestamp":1787594593042,"version":"build-2736575974"},"reference-count":126,"publisher":"Informa UK Limited","issue":"2","funder":[{"name":"EPI-MET - FUNZIONALIZZAZIONE DELLE ABERRAZIONI","award":["Prog n. F\/310034\/03\/X56"],"award-info":[{"award-number":["Prog n. F\/310034\/03\/X56"]}]},{"name":"Internal Creative Agency of VETUNI","award":["project nr. 2024ITA12"],"award-info":[{"award-number":["project nr. 2024ITA12"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1080\/13543784.2026.2627205","type":"journal-article","created":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T05:43:16Z","timestamp":1770183796000},"page":"151-168","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["Current status and perspective of immunotherapy for head and neck squamous cell carcinoma"],"prefix":"10.1080","volume":"35","author":[{"given":"Pasquale","family":"Vitale","sequence":"first","affiliation":[{"name":"Hospital of Frattamaggiore","place":["Frattamaggiore, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Di Giovanni","sequence":"additional","affiliation":[{"name":"Hospital of Frattamaggiore","place":["Frattamaggiore, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Tammaro","sequence":"additional","affiliation":[{"name":"Hospital of Frattamaggiore","place":["Frattamaggiore, Italy"]},{"name":"University of Campania Luigi Vanvitelli","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Spedaliere","sequence":"additional","affiliation":[{"name":"Hospital of Frattamaggiore","place":["Frattamaggiore, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evzen","family":"Amler","sequence":"additional","affiliation":[{"name":"Czech Technical University in Prague","place":["Prague, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alois","family":"Necas","sequence":"additional","affiliation":[{"name":"University of Veterinary Sciences Brno","place":["Brno, Czech Republic"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Scrima","sequence":"additional","affiliation":[{"name":"Biogem Scarl, Institute of Genetic Research","place":["Ariano Irpino, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Caraglia","sequence":"additional","affiliation":[{"name":"University of Campania Luigi Vanvitelli","place":["Naples, Italy"]},{"name":"Biogem Scarl, Institute of Genetic Research","place":["Ariano Irpino, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Addeo","sequence":"additional","affiliation":[{"name":"Hospital of Frattamaggiore","place":["Frattamaggiore, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,2,9]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwt029"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30588"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00603-7"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1715715"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S379173"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2012.03.023"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25528"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.00085"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/EDBK_350442"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32591-7"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-021-00131-7"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105420"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2016.08.003"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.23312"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2022.100649"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00670-9"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.02.013"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22094584"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1157"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-021-01428-1"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2018.00310"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1602252"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31999-8"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02198"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.04.001"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.17_suppl.LBA2"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.10.006"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(24)00507-2"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.09.008"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30737-3"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2022.08.029"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002485"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-1816"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2020.38.15_suppl.6583"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oraloncology.2021.105566"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.16_suppl.6012"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-002568"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.2955"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-3249"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-4484"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2020.1844403"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100426"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-21-3351"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33080-8"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2025.40.e177"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1157584"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12159"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.20517\/2574-1225.2023.124"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-018-5055-5"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9932749"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-003290"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01444-0"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.20181"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00302-8"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.04.014"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.27452"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1055-6"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.9.709"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518764416"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-014-1640-x"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-000612"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001395"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.16_suppl.6037"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2025.43.16_suppl.TPS6111"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2021-004232"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.6004"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2024.42.16_suppl.6017"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29925"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-1763"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyad085"},{"key":"e_1_3_4_74_1","unstructured":"BioNTech SE. An open-label phase II\/III randomized trial of BNT113 in combination with pembrolizumab versus pembrolizumab monotherapy as a first line therapy in patients with unresectable recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) which is positive for human papilloma virus 16 (HPV16+) and expresses PD-L1 [internet]. ClinicalTrials.gov. 2025 [cited 2025 Aug 27]. Report No.: NCT04534205. Available from: https:\/\/clinicaltrials.gov\/study\/NCT04534205"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-0202"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110888"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.51604"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01206"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S155914"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-2617"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2021.39.15_suppl.e18005"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.941750"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.currproblcancer.2020.100639"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2014.58.3377"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-1170"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S285536"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02725338"},{"issue":"22","key":"e_1_3_4_88_1","first-page":"6359","article-title":"Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: a phase II trial","volume":"60","author":"Nemunaitis J","year":"2000","unstructured":"Nemunaitis J, Ganly I, Khuri F, et al. Selective replication and oncolysis in p53 mutant tumors with ONYX-015, an E1B-55kD gene-deleted adenovirus, in patients with advanced head and neck cancer: a phase II trial. Cancer Res. 2000;60(22):6359\u20136366.","journal-title":"Cancer Res"},{"key":"e_1_3_4_89_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.2.289"},{"key":"e_1_3_4_90_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2020.1723363"},{"key":"e_1_3_4_91_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa4967"},{"key":"e_1_3_4_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2015.05.042"},{"key":"e_1_3_4_93_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2021.1929726"},{"key":"e_1_3_4_94_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2020.1756116"},{"key":"e_1_3_4_95_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1239005"},{"key":"e_1_3_4_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/cei.13407"},{"key":"e_1_3_4_97_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1261779"},{"key":"e_1_3_4_98_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2019.37.8_suppl.12"},{"key":"e_1_3_4_99_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02457"},{"key":"e_1_3_4_100_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1801137"},{"key":"e_1_3_4_101_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1272"},{"key":"e_1_3_4_102_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-0879"},{"key":"e_1_3_4_103_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-17-1243"},{"key":"e_1_3_4_104_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000407"},{"key":"e_1_3_4_105_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0b013e3181ee7095"},{"key":"e_1_3_4_106_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-19-3070"},{"key":"e_1_3_4_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-21383-1"},{"key":"e_1_3_4_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.08.010"},{"key":"e_1_3_4_109_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14242"},{"key":"e_1_3_4_110_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-4717"},{"key":"e_1_3_4_111_1","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-20-0418"},{"key":"e_1_3_4_112_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-002015"},{"key":"e_1_3_4_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2012.09.004"},{"key":"e_1_3_4_114_1","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2020-000738"},{"key":"e_1_3_4_115_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aat7061"},{"key":"e_1_3_4_116_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40425-018-0407-x"},{"key":"e_1_3_4_117_1","doi-asserted-by":"publisher","DOI":"10.1097\/CJI.0000000000000275"},{"key":"e_1_3_4_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20090"},{"key":"e_1_3_4_119_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-018-2642-4"},{"key":"e_1_3_4_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol29060334"},{"key":"e_1_3_4_121_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2015.101"},{"key":"e_1_3_4_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(16)30066-3"},{"key":"e_1_3_4_123_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1713444"},{"key":"e_1_3_4_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2018.11"},{"key":"e_1_3_4_125_1","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-17-0080"},{"key":"e_1_3_4_126_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0044952"},{"key":"e_1_3_4_127_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-2951"},{"key":"e_1_3_4_128_1","doi-asserted-by":"publisher","DOI":"10.69613\/zveq1612"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2026.2627205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:35:29Z","timestamp":1773221729000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2026.2627205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":126,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1080\/13543784.2026.2627205"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2026.2627205","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-06-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}