{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:04:35Z","timestamp":1789718675906,"version":"4.0.1"},"reference-count":52,"publisher":"Informa UK Limited","issue":"9","license":[{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Investigational Drugs"],"published-print":{"date-parts":[[2026,9,2]]},"DOI":"10.1080\/13543784.2026.2717160","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T12:33:32Z","timestamp":1786624412000},"page":"675-684","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Receptor interacting protein kinase 1 as a potential therapeutic target in inflammatory bowel disease: biological rationale and emerging clinical evidence"],"prefix":"10.1080","volume":"35","author":[{"given":"Sailish","family":"Honap","sequence":"first","affiliation":[{"name":"St George\u2019s University Hospitals NHS Foundation Trust","place":["London, UK"]},{"name":"University of London","place":["London, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axel","family":"Dignass","sequence":"additional","affiliation":[{"name":"Goethe University","place":["Frankfurt, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vipul","family":"Jairath","sequence":"additional","affiliation":[{"name":"Western University","place":["London, Canada"]},{"name":"Western University","place":["London, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Magro","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina da Universidade do Porto","place":["Porto, Portugal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Danese","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale San Raffaele","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Peyrin-Biroulet","sequence":"additional","affiliation":[{"name":"McGill University Health Centre","place":["Montreal, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,8,13]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08940-0"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00966-2"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)02586-2"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-024-01035-7"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2025.102577"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2021.1898944"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04240-3"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.02.003"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3206"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2127-x"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.12448"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.08.014"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2026.02.006"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90072-1"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-020-0071-y"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00630-3"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2011-301364"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1642593"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10400"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10273"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13608"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2020.06.014"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1159743"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3683"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13706"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjab232.103"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjae190.0148"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46365-x"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaf231.332"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1155\/2024\/7275309"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.01.002"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.176"},{"issue":"10","key":"e_1_3_5_35_1","first-page":"3174","article-title":"Necrostatin-1 reduces intestinal inflammation and colitis-associated tumorigenesis in mice","volume":"5","author":"Liu ZY","year":"2015","unstructured":"Liu ZY, Wu B, Guo YS, et al. Necrostatin-1 reduces intestinal inflammation and colitis-associated tumorigenesis in mice. Am J Cancer Res. 2015;5(10):3174\u20133185. PubMed PMID: 26693068; PubMed Central PMCID: PMC4656739.","journal-title":"Am J Cancer Res"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecco-jcc\/jjaa131"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13538"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01751"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175381"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.05.017"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2023.10.021"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1580-7"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20181081"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.365"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgast-2021-000680"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-021-02468-0"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-024-01097-0"},{"key":"e_1_3_5_48_1","unstructured":"AbbVie. A phase 1 relative bioavailability and food effect study of ABBV-668 extended-release formulations [Clinical trial registration] [Internet]. Clinical trial registration no.: nCT06477926. Available from: clinicaltrials.gov; 2024 [cited 2026 Mar 18]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT06477926"},{"key":"e_1_3_5_49_1","unstructured":"AbbVie. A single-arm open-label study to evaluate the efficacy and safety of ABBV-668 in subjects with moderate to severe ulcerative colitis [Clinical trial registration] [Internet]. Clinical trial registration no.: nCT05570006. Available from: clinicaltrials.gov; 2025 [cited 2026 Mar 18]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT05570006"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-025-03255-y"},{"key":"e_1_3_5_51_1","unstructured":"Sanofi. A randomized Double-blind placebo controlled dose-finding study to assess the efficacy and safety of SAR443122 in adult patients with moderate to severe ulcerative colitis [Clinical trial registration] [Internet]. Clinical trial registration no.: nCT05588843. Available from: clinicaltrials.gov; 2026 [cited 2026 Mar 18]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT05588843"},{"key":"e_1_3_5_52_1","unstructured":"Waldron J. Sanofi keeps mum on denali pact after scrapping final RIPK1 drug [Internet]. 2026 [cited 2026 Mar 18]. Available from: https:\/\/www.fiercebiotech.com\/biotech\/sanofi-keeps-mum-future-denali-pact-after-scrapping-final-ripk1-inhibitor"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1615"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar2641"}],"container-title":["Expert Opinion on Investigational Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2026.2717160","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/13543784.2026.2717160","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13543784.2026.2717160","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T07:56:07Z","timestamp":1789718167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13543784.2026.2717160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,13]]},"references-count":52,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9,2]]}},"alternative-id":["10.1080\/13543784.2026.2717160"],"URL":"https:\/\/doi.org\/10.1080\/13543784.2026.2717160","relation":{},"ISSN":["1354-3784","1744-7658"],"issn-type":[{"value":"1354-3784","type":"print"},{"value":"1744-7658","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,13]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieid20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}