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Two cannabinoid receptor agonists, \u0394<jats:sup>9<\/jats:sup>\u2010tetrahydrocannabinol and nabilone, are used clinically as anti\u2010emetics or to boost appetite. Additional therapeutic uses of cannabinoids may include the suppression of some multiple sclerosis and spinal injury symptoms, the management of pain, bronchial asthma and glaucoma, and the prevention of neurotoxicity. There are also potential clinical applications for CB 1 receptor antagonists, in the management of acute schizophrenia and cognitive\/memory dysfunctions and as appetite suppressants. Future research is likely to be directed at characterizing the endogenous cannabinoid system more completely, at obtaining more conclusive clinical data about cannabinoids with regard to both beneficial and adverse effects, at developing improved cannabinoid formulations and modes of administration for use in the clinic and at devising clinical strategies for separating out the sought\u2010after effects of CB 1 receptor agonists from their psychotropic and other unwanted effects.<\/jats:p>","DOI":"10.1080\/13556210071252","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:13:17Z","timestamp":1027699997000},"page":"37-46","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Neuropharmacology and therapeutic potential of cannabinoids"],"prefix":"10.1111","volume":"5","author":[{"given":"Roger 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