{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,14]],"date-time":"2026-11-14T05:03:28Z","timestamp":1794632608752,"version":"4.9.1"},"reference-count":61,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T00:00:00Z","timestamp":1149811200000},"content-version":"vor","delay-in-days":281,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acamprosate (Campral ?) is a drug used clinically for the treatment of alcoholism. In order to examine further the time\u2010course and mechanism of action of acamprosate, the effect of acute and repeated acamprosate administration was examined on (i) operant ethanol self\u2010administration and (ii) voluntary home cage ethanol consumption by alcohol\u2010preferring Fawn\u2010Hooded, iP and Alko Alcohol (AA) rats. Acutely, acamprosate was shown to cause a significant decrease in operant ethanol self\u2010administration by Fawn\u2010Hooded and alcohol\u2010preferring iP rats in part by decreasing the motivational relevance of a specific ethanol cue; however, repeated injection of acamprosate led to tolerance to this effect. Voluntary alcohol consumption in the home cage in Fawn\u2010Hooded and AA rats was also reduced by an acute acamprosate injection; however, again tolerance developed to repeated injections. In a separate experiment, the effect of acamprosate on markers of the dopaminergic system was examined. Interestingly, acute acamprosate was also shown to cause increased dopamine transporter density and decreased dopamine D2\u2010like receptor density within the nucleus accumbens but not in the caudate\u2010putamen, suggesting a link between the decreased motivational salience of the ethanol cue and altered dopaminergic signalling within the nucleus accumbens. With repeated injections of acamprosate, markers of the dopaminergic system returned to steady state levels with a similar temporal profile to the development of tolerance in the behavioural studies. Along with previous studies, our findings indicate that acamprosate modulates the mesolimbic dopaminergic system and may thereby decrease ethanol reinforcement processes; however, these effects undergo tolerance in alcohol\u2010preferring rats and may in part explain the fact why some subjects are non\u2010responders to chronic acamprosate treatment.<\/jats:p>","DOI":"10.1080\/13556210500223132","type":"journal-article","created":{"date-parts":[[2005,9,7]],"date-time":"2005-09-07T13:55:47Z","timestamp":1126101347000},"page":"233-242","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["The acute anti\u2010craving effect of acamprosate in alcohol\u2010preferring rats is associated with modulation of the mesolimbic dopamine system"],"prefix":"10.1111","volume":"10","author":[{"given":"Michael","family":"Cowen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Adams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey","family":"Kraehenbuehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Vengeliene","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Lawrence","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,6,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00174-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1163"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00175-6"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(99)01447-2"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(97)89800-8"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00176-8"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)91682-7"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90682-8"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/j.1530-0277.1998.tb03872.x","article-title":"Mechanism of action of acamprosate Part II. Ethanol dependence modifies effects of acamprosate on NMDA receptor binding in membranes from rat cerebral cortex","volume":"22","author":"Al Qatari M","year":"1998","journal-title":"Alcohol Clin Exp Res"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002100000285"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300657"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb03636.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(84)80020-9"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-003-0795-3"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-002-0674-3"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050009"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02220.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4927(98)00016-X"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(02)00179-9"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.035915"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.alcalc.a045093"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300070"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2002.tb02484.x"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(97)00130-9"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1997.tb04257.x"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1997.tb03850.x"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000084029.22282.bb"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2003.09.001"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.60.1.92"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2001.tb02356.x"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb13352.x"},{"key":"e_1_2_1_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(87)90006-1"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(87)90005-X"},{"key":"e_1_2_1_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)91615-0"},{"key":"e_1_2_1_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.alcalc.a045057"},{"key":"e_1_2_1_37_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1995.90911793.x"},{"key":"e_1_2_1_38_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1996.tb01667.x"},{"key":"e_1_2_1_39_2","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200418080-00002"},{"key":"e_1_2_1_40_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000108656.81563.05"},{"key":"e_1_2_1_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/3-7643-7305-9_8"},{"key":"e_1_2_1_42_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705059"},{"key":"e_1_2_1_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300185"},{"key":"e_1_2_1_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1998.tb03871.x"},{"key":"e_1_2_1_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050785"},{"key":"e_1_2_1_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01272-4"},{"key":"e_1_2_1_47_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00179.x"},{"key":"e_1_2_1_48_2","first-page":"239","article-title":"Double\u2010blind randomized multicentre trial of acamprosate in maintaining abstinence from alcohol","volume":"30","author":"Paille FM","year":"1995","journal-title":"Alcohol Alcohol"},{"key":"e_1_2_1_49_2","doi-asserted-by":"publisher","DOI":"10.1002\/syn.10174"},{"key":"e_1_2_1_50_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.171.1.73"},{"key":"e_1_2_1_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00195-3"},{"key":"e_1_2_1_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(96)00696-6"},{"key":"e_1_2_1_53_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1186-z"},{"key":"e_1_2_1_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(01)00008-9"},{"key":"e_1_2_1_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb26013.x"},{"key":"e_1_2_1_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(95)02033-0"},{"key":"e_1_2_1_57_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0593com"},{"key":"e_1_2_1_58_2","doi-asserted-by":"publisher","DOI":"10.2165\/00003088-199835050-00001"},{"key":"e_1_2_1_59_2","first-page":"469","article-title":"The role of the mesoaccumbens dopamine system in ethanol reinforcement: studies using the techniques of microinjection and voltammetry","volume":"2","author":"Samson HH","year":"1993","journal-title":"Alcohol Alcohol Suppl"},{"key":"e_1_2_1_60_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1988.tb00248.x"},{"key":"e_1_2_1_61_2","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1996.01830080023006"},{"key":"e_1_2_1_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-8329(96)00153-X"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F13556210500223132","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/13556210500223132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T05:24:06Z","timestamp":1700198646000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/13556210500223132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":61,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1080\/13556210500223132"],"URL":"https:\/\/doi.org\/10.1080\/13556210500223132","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9]]},"assertion":[{"value":"2006-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}