{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T15:34:44Z","timestamp":1700321684683},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,6,9]],"date-time":"2006-06-09T00:00:00Z","timestamp":1149811200000},"content-version":"vor","delay-in-days":2991,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Addiction Biology"],"published-print":{"date-parts":[[1998,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Carbohydrate\u2010deficient transferrin (CDT) was assayed in 105 patients with non\u2010alcohol\u2010related liver diseases, 50 patients with alcohol\u2010induced liver disease and 40 alcohol misusers with minimal hepatic dysfunction. The patients with liver disease were hospitalized for assessment of suitability for orthotopic liver transplantation. CDT was measured by two commercially available micro anion exchange methods; CDTect (Pharmacia) and %CDT (AXIS). Additionally, total transferrin was measured to allow expression of the CDTect results as \u2018relative\u2019 measurements. Overall, 41\/105 (39%) of patients with non\u2010alcohol\u2010related liver diseases had a raised CDTect result, 13\/105 (12%) had a raised %CDT result and 26\/105 (25%) an abnormal CDTect\/total transferrin ratio. In general, patients with cholestatic liver disease, primary biliary cirrhosis or primary sclerosing cholangitis had more \u2018false positive\u2019 results by CDTect than did those with viral or autoimmune hepatitis. The sensitivity of the two methods for the detection of alcohol misuse was similar; CDTect 77%, %CDT 65% and CDTect\/total transferrin ratio 70%. This was, however, lower than the sensitivity of the conventional marker GGT (82%). In patients with severe liver disease, where up to 30% of the serum total transferrin concentrations fall outside the reference range, \u2018relative\u2019 CDT methods have greater specificity than \u2018absolute\u2019 measurements.<\/jats:p>","DOI":"10.1080\/13556219872263","type":"journal-article","created":{"date-parts":[[2002,7,26]],"date-time":"2002-07-26T16:11:58Z","timestamp":1027699918000},"page":"205-211","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Carbohydrate deficient transferrin in alcoholic and non\u2010alcoholic liver disease: a comparison of two assay methods"],"prefix":"10.1111","volume":"3","author":[{"given":"JAMES","family":"KEATING","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CONNIE","family":"CHEUNG","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"TIMOTHY J.","family":"PETERS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROBERT","family":"PRZEMIOSLO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROGER","family":"WILLIAMS","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"ROY A.","family":"SHERWOOD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,6,9]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/37.12.2029"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1994.tb00043.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1987.tb01925.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1988.tb00221.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1093\/clinchem\/41.6.858","article-title":"Carbohydrate\u2010deficient transferrin and false\u2010positive results for alcohol abuse in primary biliary cirrhosis: differential diagnosis by detection of mitochondrial auto\u2010antibodies","volume":"41","author":"Bean P","year":"1995","journal-title":"Clin Chem"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1993.tb00757.x"},{"key":"e_1_2_1_8_2","first-page":"171","article-title":"Evaluation of carbohydrate\u2010deficient transferrin for detection of alcohol abuse in patients with liver dysfunction","volume":"30","author":"Stauber RE","year":"1995","journal-title":"Alcohol Alcohol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(95)80037-9"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb01018.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1996.tb01074.x"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840220520"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840050503"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1995.tb01601.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.alcalc.a008167"}],"container-title":["Addiction Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F13556219872263","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/13556219872263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T07:00:56Z","timestamp":1698476456000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/13556219872263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,4]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1998,4]]}},"alternative-id":["10.1080\/13556219872263"],"URL":"https:\/\/doi.org\/10.1080\/13556219872263","archive":["Portico"],"relation":{},"ISSN":["1355-6215","1369-1600"],"issn-type":[{"value":"1355-6215","type":"print"},{"value":"1369-1600","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,4]]},"assertion":[{"value":"2006-06-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}