{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:43:48Z","timestamp":1792082628524,"version":"4.4.0"},"reference-count":0,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Sarcoma"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:p><jats:italic>Purpose<\/jats:italic>. The influence of initial inadequate excision (IIE) of soft tissue sarcoma (STS) on local control and overall survival\nis not well established. It is generally believed that an IIE may have a negative impact on both, despite subsequent treatment\nby radical surgery and radiotherapy. However, data on local recurrence\u2010free survival\/overall survival are conflicting and there\nare no data on the effect of IIE on overall survival.<\/jats:p><jats:p><jats:italic>Patients and methods<\/jats:italic>. A retrospective analysis was made of 86 patients with soft tissue sarcoma of the extremities and trunk\nafter an IIE had been performed due to inappropriate work\u2010up. The minimal follow\u2010up was 7 years. Specimens of the\nsubsequent radical resection were evaluated for residual tumor, grade of tumor and complications of IIE. Endpoints were\nrecurrence\u2010free survival and overall survival.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>. Specimens of the subsequent radical resection showed residual tumor in 66 patients (77%). The most common\ncomplication after IIE was hematoma. In both univariate and multivariate analyses, grade II\/III tumors and complications\nafter IIE are significant negative prognostic factors for local recurrence\u2010free survival (<jats:italic>P<\/jats:italic> = 0.008 and <jats:italic>P<\/jats:italic> = 0.002, respectively,\nin the Cox model). For this survival, three prognostic groups could be formed based on grade, or presence or absence of\ncomplications. Adjuvant radiotherapy did not change the rate of local recurrence\u2010free survival. For overall survival, only\ntumor grade is a significant factor (log\u2010rank test).<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>. This retrospective study shows that complications associated with an IIE have a significant negative effect on\nlocal control, but not on overall survival, because IIE is often the result of inappropriate work\u2010up before surgery. For better\ndiagnosis and therapy STS should be treated in specialized centers.<\/jats:p>","DOI":"10.1080\/13577140310001650321","type":"journal-article","created":{"date-parts":[[2003,12,30]],"date-time":"2003-12-30T17:15:02Z","timestamp":1072804502000},"page":"159-165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Factors Influencing Prognosis After Initial Inadequate Excision(IIE) for Soft Tissue Sarcoma"],"prefix":"10.1155","volume":"7","author":[{"given":"Albert N.","family":"Van Geel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander M. M.","family":"Eggermont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick E. J.","family":"Hanssens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul I. M.","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2003,1]]},"container-title":["Sarcoma"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/sarcoma\/2003\/250140.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/13577140310001650321","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T23:37:28Z","timestamp":1723073848000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1080\/13577140310001650321"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":0,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1080\/13577140310001650321"],"URL":"https:\/\/doi.org\/10.1080\/13577140310001650321","archive":["Portico"],"relation":{},"ISSN":["1357-714X","1369-1643"],"issn-type":[{"value":"1357-714X","type":"print"},{"value":"1369-1643","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]},"assertion":[{"value":"2003-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}