{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:08:50Z","timestamp":1785247730023,"version":"3.55.0"},"reference-count":35,"publisher":"Informa UK Limited","issue":"4","license":[{"start":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:00:00Z","timestamp":1772496000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["The European Journal of Contraception & Reproductive Health Care"],"published-print":{"date-parts":[[2026,7,4]]},"DOI":"10.1080\/13625187.2026.2636802","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T08:52:48Z","timestamp":1772700768000},"page":"320-335","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Comparative effectiveness of misoprostol plus letrozole versus misoprostol alone for pharmacological abortion: a systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1080","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0640-4040","authenticated-orcid":false,"given":"Katherine Ann Reim\u00e3o","family":"Miller","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Santo Amaro","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5792-4760","authenticated-orcid":false,"given":"Giovanna Cristina","family":"de Castro Martin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Faculty Santa Marcelina","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5771-179X","authenticated-orcid":false,"given":"Ana Clara Pimenta","family":"Servidoni","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Faculty Santa Marcelina","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1550-0985","authenticated-orcid":false,"given":"Priscila Luiza","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Faculty Santa Marcelina","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-9778-9624","authenticated-orcid":false,"given":"Maria Julia","family":"Lemos","sequence":"additional","affiliation":[{"name":"Redentor University Center","place":["Itaperuna, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5842-8286","authenticated-orcid":false,"given":"Hellen","family":"Pereira","sequence":"additional","affiliation":[{"name":"University of Messina","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7708-7995","authenticated-orcid":false,"given":"Hanna","family":"Surmann","sequence":"additional","affiliation":[{"name":"Yale University","place":["New Haven, USA"]},{"name":"Department of Gynecology and Obstetrics, M\u00fcnster University Hospital","place":["M\u00fcnster, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2828-1433","authenticated-orcid":false,"given":"Ana Paula","family":"Beck","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, Albert Einstein Institute for Education and Research, Hospital Israelita Albert Einstein","place":["S\u00e3o Paulo, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61575-X"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186487"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200510000-00051"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000910"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002855.pub5"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000000897"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000130842.21897.53"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0000000000003017"},{"issue":"1","key":"e_1_3_3_10_1","first-page":"27","article-title":"Comparison between effect of letrozole plus misoprostol and misoprostol alone in terminating non-viable first trimester pregnancies: a single blind randomized trial","volume":"12","author":"Abbasalizadeh F","year":"2018","unstructured":"Abbasalizadeh F, Sahhaf F, Sadeghi-Shabestari P, et al. Comparison between effect of letrozole plus misoprostol and misoprostol alone in terminating non-viable first trimester pregnancies: a single blind randomized trial. J Fam Reprod Health. 2018;12(1):27\u201333.","journal-title":"J Fam Reprod Health"},{"issue":"1","key":"e_1_3_3_11_1","first-page":"2712","article-title":"Medical induction of first trimester abortion by misoprostol or misoprostol with letrozole","volume":"15","author":"Al-Taie MJM","year":"2021","unstructured":"Al-Taie MJM, Alobaidy EJ, Kurji HA. Medical induction of first trimester abortion by misoprostol or misoprostol with letrozole. Indian J Forensic Med Toxicol. 2021;15(1):2712\u20132717.","journal-title":"Indian J Forensic Med Toxicol"},{"key":"e_1_3_3_12_1","volume-title":"Abortion care guideline","author":"World Health Organization","year":"2022","unstructured":"World Health Organization. Abortion care guideline. Geneva: World Health Organization; 2022. https:\/\/www.who.int\/publications\/i\/item\/9789240039483"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijgo.13326"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jogoh.2017.11.002"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2017.11.003"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2016.04.013"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2021.07.004"},{"key":"e_1_3_3_19_1","unstructured":"The Cochrane Collaboration. Review Manager (RevMan) [Computer Program]. Version 5.4; 2020. training.cochrane.org"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"issue":"1","key":"e_1_3_3_22_1","first-page":"180006","article-title":"Letrozole combined with misoprostol versus misoprostol alone in the management of patients with first trimester delayed miscarriages: our experience","volume":"2","author":"Elbareg AM","year":"2019","unstructured":"Elbareg AM, Essadi FM. Letrozole combined with misoprostol versus misoprostol alone in the management of patients with first trimester delayed miscarriages: our experience. Online J Gynecol Obstet Maternity Care. 2019;2(1):180006.","journal-title":"Online J Gynecol Obstet Maternity Care"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.21608\/ebwhj.2021.112340.1163"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43043-023-00152-8"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0043-122499"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det345"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.22088\/jbums.25.1.526"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-1995.165964"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.5812\/semj-131460"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2010.05.014"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-0479"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(00)70235-3"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2015.07.018"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2012.02.008"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.11115"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.contraception.2015.12.005"}],"container-title":["The European Journal of Contraception & Reproductive Health Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13625187.2026.2636802","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/13625187.2026.2636802","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13625187.2026.2636802","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T13:28:53Z","timestamp":1785245333000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13625187.2026.2636802"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,3]]},"references-count":35,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7,4]]}},"alternative-id":["10.1080\/13625187.2026.2636802"],"URL":"https:\/\/doi.org\/10.1080\/13625187.2026.2636802","relation":{},"ISSN":["1362-5187","1473-0782"],"issn-type":[{"value":"1362-5187","type":"print"},{"value":"1473-0782","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,3]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iejc20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iejc20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-08","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}