{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:44:45Z","timestamp":1792421085627,"version":"4.5.0"},"reference-count":75,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"funder":[{"name":"Moderna, Inc"},{"name":"Inizio Ignite Putnam"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Medical Economics"],"published-print":{"date-parts":[[2026,12,31]]},"DOI":"10.1080\/13696998.2026.2746277","type":"journal-article","created":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:32:09Z","timestamp":1792420329000},"page":"2552-2571","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Cost\u2011effectiveness analysis of the mRNA\u20111345 RSV vaccine for older adults in Italy"],"prefix":"10.1080","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1645-5678","authenticated-orcid":false,"given":"Mariia","family":"Dronova","sequence":"first","affiliation":[{"name":"Inizio Ignite Putnam","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6217-8283","authenticated-orcid":false,"given":"Camille","family":"Moyon","sequence":"additional","affiliation":[{"name":"Inizio Ignite Putnam","place":["Paris, France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1421-1804","authenticated-orcid":false,"given":"Lukasz","family":"Pyrek","sequence":"additional","affiliation":[{"name":"Inizio Ignite Putnam","place":["Krakow, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1058-3401","authenticated-orcid":false,"given":"Katherine","family":"Hicks","sequence":"additional","affiliation":[{"name":"RTI Health Solutions","place":["Durham, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0299-5789","authenticated-orcid":false,"given":"Ziyi","family":"Xiao","sequence":"additional","affiliation":[{"name":"RTI Health Solutions","place":["Durham, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Rumi","sequence":"additional","affiliation":[{"name":"ALTEMS Advisory, Spin-off of Universit\u00e0 Cattolica del Sacro Cuore","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4346-1494","authenticated-orcid":false,"given":"Chiara","family":"de Waure","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Perugia","place":["Perugia, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8421-8829","authenticated-orcid":false,"given":"Stefan","family":"Scholz","sequence":"additional","affiliation":[{"name":"Moderna Germany GmbH","place":["Munich, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2883-5590","authenticated-orcid":false,"given":"Parinaz","family":"Ghaswalla","sequence":"additional","affiliation":[{"name":"Moderna Inc.","place":["Cambridge, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_3_8_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41479-025-00160-4"},{"key":"e_1_3_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2025.2479334"},{"key":"e_1_3_8_4_1","unstructured":"National Institute of Allergy and Infectious Diseases. Respiratory syncytial virus (RSV); 2022 [cited 2026 Jul 7]. Available from: https:\/\/www.niaid.nih.gov\/diseases-conditions\/respiratory-syncytial-virus-rsv"},{"key":"e_1_3_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiad189"},{"key":"e_1_3_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.13031"},{"key":"e_1_3_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/diseases13030068"},{"key":"e_1_3_8_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0297608"},{"key":"e_1_3_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2024.02.011"},{"key":"e_1_3_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-023-00792-3"},{"key":"e_1_3_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-024-03687-3"},{"key":"e_1_3_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofac300"},{"key":"e_1_3_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-025-01241-z"},{"key":"e_1_3_8_14_1","unstructured":"World Health Organization. Respiratory syncytial virus (RSV); 2025 [cited 2026 Jul 7]. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/respiratory-syncytial-virus-(rsv)"},{"key":"e_1_3_8_15_1","unstructured":"European Medicines Agency. Arexvy - respiratory syncytial virus (RSV) vaccine (recombinant adjuvanted); 2026 [cited 2026 Jul 7]. Available from: https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/arexvy"},{"key":"e_1_3_8_16_1","unstructured":"European Medicines Agency. Abrysvo - respiratory syncytial virus (RSV) vaccine (bivalent recombinant); 2026 [cited 2026 Jul 7]. Available from: https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/abrysvo"},{"key":"e_1_3_8_17_1","unstructured":"European Medicines Agency. mResvia - Respiratory Syncytial Virus (RSV) mRNA vaccine; 2026 [cited 2026 Jul 7]. Available from: https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/mresvia"},{"key":"e_1_3_8_18_1","unstructured":"Board del Calendario per la Vita. Calendario vaccinale per la vita-5 edizione; 2025 [cited 2026 Jul 10]. Available from: https:\/\/www.fimp.pro\/images\/aree%20tematiche\/Calendario_Vaccinale_per_la_Vita_2025_241218_131601.pdf"},{"key":"e_1_3_8_19_1","unstructured":"Societ\u00e0 Italiana di Malattie Infettive e tropicali. SItI-SIMIT: pubblicato un documento per la prevenzione delle infezioni da Virus Respiratorio Sinciziale; 2024 [cited 2026 Jul 7]. Available from: https:\/\/www.igienistionline.it\/docs\/2024\/03rsvcs.pdf"},{"key":"e_1_3_8_20_1","doi-asserted-by":"publisher","DOI":"10.53854\/liim-3204-6"},{"key":"e_1_3_8_21_1","doi-asserted-by":"publisher","DOI":"10.15167\/2421-4248\/jpmh2024.65.2s1"},{"key":"e_1_3_8_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/CEOR.S584975"},{"key":"e_1_3_8_23_1","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2026.2626916"},{"key":"e_1_3_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10198-026-01968-7"},{"key":"e_1_3_8_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273-022-01215-w"},{"key":"e_1_3_8_26_1","unstructured":"Istituto Nazionale di Statistica. Popolazione residente; 2026 [cited 2026 Jul 1]. Available from: https:\/\/demo.istat.it\/app\/?i=POS"},{"key":"e_1_3_8_27_1","unstructured":"Istituto Superiore di Sanit\u00e0. La sorveglianza Passi d\u2019Argento: patologie croniche 2023\u20132024; 2026 [cited 2026 Jul 1]. Available from: https:\/\/www.epicentro.iss.it\/passi-argento\/dati\/croniche"},{"key":"e_1_3_8_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307079"},{"key":"e_1_3_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2026.128882"},{"key":"e_1_3_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(24)01738-0"},{"key":"e_1_3_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.15896"},{"key":"e_1_3_8_32_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02688-2020"},{"key":"e_1_3_8_33_1","unstructured":"Bella A Giombini E Urdiales AM et al. La sorveglianza integrata dei virus respiratori RespiVirNet in Italia: i risultati della stagione 2023-2024; 2024 [cited 2026 Jul 21]. Available from: https:\/\/www.epicentro.iss.it\/ben\/2024\/4\/respivirnet-2023-2024"},{"key":"e_1_3_8_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1218-z"},{"key":"e_1_3_8_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiad510"},{"key":"e_1_3_8_36_1","doi-asserted-by":"publisher","DOI":"10.7416\/ai.2026.18238"},{"key":"e_1_3_8_37_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40248-018-0119-6"},{"key":"e_1_3_8_38_1","unstructured":"Istituto Nazionale di Statistica. Life tables by age; 2025 [cited 2026 Jul 6]. Available from: https:\/\/esploradati.istat.it\/databrowser\/#\/en\/dw\/categories\/IT1 POP 1.0\/POP_MORTALITY\/DCIS_MORTALITA1\/IT1 26_295_DF_DCIS_MORTALITA1_2 1.0"},{"key":"e_1_3_8_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/irv.70049"},{"key":"e_1_3_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2023.107404"},{"key":"e_1_3_8_41_1","unstructured":"Ministero della Salute. Vaccinazione antinfluenzale: 2024-2025 \u2013 Coperture Vaccinali per 100 abitanti; 2025 [cited 2026 Jul 7]. Available from: https:\/\/www.salute.gov.it\/new\/sites\/default\/files\/2025-10\/CopertureVaccinaliInfluenzaAggiornatoSettembre2025.pdf"},{"key":"e_1_3_8_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines13030212"},{"key":"e_1_3_8_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-025-61153-x"},{"key":"e_1_3_8_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaf695.1632"},{"key":"e_1_3_8_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaf695.1640"},{"key":"e_1_3_8_46_1","unstructured":"Das R. Update on Moderna\u2019s RSV vaccine mRESVIA (mRNA-1345) in adults \u2265 60 years of age: Advisory Committee on Immunization Practices (ACIP); 2024 [cited 2026 Jul 21]. Available from: https:\/\/www.cdc.gov\/acip\/downloads\/slides-2024-06-26-28\/04-RSV-Adult-Das-508.pdf"},{"key":"e_1_3_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jval.2012.06.012"},{"key":"e_1_3_8_48_1","unstructured":"Italian Ministry of Health. Main features: Diagnosis Related Groups (DRG); 2013 [cited 2026 Jul 6]. Available from: https:\/\/www.salute.gov.it\/new\/it\/tema\/assistenza-ospedaliera\/principali-caratteristiche-diagnosis-related-groups-drg\/"},{"key":"e_1_3_8_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2018.1438792"},{"key":"e_1_3_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2018.07.001"},{"key":"e_1_3_8_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01802-8"},{"key":"e_1_3_8_52_1","unstructured":"ILOSTAT. Italy profile - working conditions and social protection; 2025 [cited 2026 Jul 6]. Available from: https:\/\/ilostat.ilo.org\/data\/country-profiles\/ita\/"},{"key":"e_1_3_8_53_1","unstructured":"ILOSTAT. EU Labour Force Survey. Labour force participation rate by sex and age (%); 2025 [cited 2026 Jul 6]. Available from: https:\/\/ilostat.ilo.org\/data\/?cat_mode=subject"},{"key":"e_1_3_8_54_1","unstructured":"Istituto Nazionale di Statistica. The wage structure in Italy - year 2022; 2022 [cited 2026 Jul 6]. Available from: https:\/\/www.istat.it\/comunicato-stampa\/la-struttura-delle-retribuzioni-in-italia-anno-2022\/"},{"key":"e_1_3_8_55_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-2347"},{"key":"e_1_3_8_56_1","unstructured":"OECD Data Explorer. Average annual wages for Italy; 2025 [cited 2026 Jul 6]. Available from: https:\/\/data-explorer.oecd.org\/vis?df[ds]=DisseminateFinalDMZ&df[id]=DSD_EARNINGS%40AV_AN_WAGE&df[ag]=OECD.ELS.SAE&dq=ITA.EUR\u2026.&pd=2005 &to[TIME_PERIOD]=false&vw=tb"},{"key":"e_1_3_8_57_1","unstructured":"Agenzia Italiana del Farmaco. Guidelines for the compilation of the dossier to support the health technology assessment of a medicinal product for the purposes of refundability and the price charged by the NHS; 2025 [cited 2026 Jul 7]. Available from: https:\/\/www.aifa.gov.it\/documents\/20142\/3214492\/Linee_guida_dossier_domanda_rimborsabilita_vers-2-2025.pdf"},{"key":"e_1_3_8_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2018.1542520"},{"key":"e_1_3_8_59_1","unstructured":"Istituto Nazionale di Statistica. Consumer price index for the whole nation (NIC) - annual average from 2011 until 2015 (base 2010); n.d. [cited 2026 Jul 6]. Available from: https:\/\/esploradati.istat.it\/databrowser\/#\/en\/dw\/categories\/IT1 Z0400PRI 1.0\/PRI_CONWHONAT\/PRI_CONWHONAT_BRI\/DCSP_NICDUEB2010\/IT1 167_34_DF_DCSP_NICDUEB2010_1 1.0"},{"key":"e_1_3_8_60_1","unstructured":"Istituto Nazionale di Statistica. Consumer price index for the whole nation (NIC) - annual average from 2016 onwards (base 2015); n.d. [cited 2026 Jul 6]. Available from: https:\/\/esploradati.istat.it\/databrowser\/#\/en\/dw\/categories\/IT1 Z0400PRI 1.0\/PRI_CONWHONAT\/DCSP_NIC2B2015\/IT1 167_742_DF_DCSP_NIC2B2015_1 1.0"},{"key":"e_1_3_8_61_1","doi-asserted-by":"publisher","DOI":"10.2427\/11457"},{"key":"e_1_3_8_62_1","unstructured":"Hutton D. Economic analysis of RSV vaccination in older adults; 2023 [cited 2026 Jul 1]. Available from: https:\/\/www.cdc.gov\/acip\/downloads\/slides-2023-02-22-24\/RSV-Adults-02-Hutton-508.pdf"},{"key":"e_1_3_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2024.126294"},{"key":"e_1_3_8_64_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciad658"},{"key":"e_1_3_8_65_1","doi-asserted-by":"crossref","unstructured":"Briggs A Sculpher M Claxton K. Decision modelling for health economic evaluation; 2006 [cited 2026 Jul 7]. Available from: https:\/\/econpapers.repec.org\/bookchap\/oxpobooks\/9780198526629.htm","DOI":"10.1093\/oso\/9780198526629.001.0001"},{"key":"e_1_3_8_66_1","unstructured":"OECD\/European Observatory on Health Systems and Policies. Italy: country health profile 2023. State of health in the EU. 2023 [cited 2026 Jul 16]. Available from: https:\/\/www.oecd.org\/content\/dam\/oecd\/en\/publications\/reports\/2023\/12\/italy-country-health-profile-2023_9404b600\/633496ec-en.pdf"},{"key":"e_1_3_8_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-024-01041-x"},{"key":"e_1_3_8_68_1","unstructured":"UKHSA\/NHS England. Respiratory syncytial virus (RSV) older adults vaccination coverage in England: July 2026 report; 2026 [cited 2026 Sept 21]. Available from: https:\/\/www.gov.uk\/government\/statistics\/respiratory-syncytial-virus-rsv-older-adults-vaccination-coverage-in-england\/respiratory-syncytial-virus-rsv-older-adults-vaccination-coverage-in-england-july-2026-report"},{"key":"e_1_3_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2022.101410"},{"key":"e_1_3_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2022.01.015"},{"key":"e_1_3_8_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofaf695.079"},{"key":"e_1_3_8_72_1","unstructured":"Agenzia Italiana del Farmaco. Transparency lists; 2025 [cited 2026 Jul 8]. Available from: https:\/\/www.aifa.gov.it\/en\/liste-di-trasparenza"},{"key":"e_1_3_8_73_1","unstructured":"Ministero della Salute. Ministry of Health decree of November 25 2024; 2024 [cited 2026 Jul 8]. Available from: https:\/\/www.trovanorme.salute.gov.it\/norme\/renderNormsanPdf?anno=2024&codLeg=104476&parte=1%20&serie=null"},{"key":"e_1_3_8_74_1","volume-title":"Assessing healthcare resource use and economic burden among an older population of patients with respiratory syncytial virus in five European countries using real-world data","author":"Mendes D","year":"2024","unstructured":"Mendes D, Hughes M, Li K, et al. Assessing healthcare resource use and economic burden among an older population of patients with respiratory syncytial virus in five European countries using real-world data. Barcelona, Spain: ISPOR Europe; 2024 [cited 2026 Jul 7]. Available from: https:\/\/www.ispor.org\/docs\/default-source\/euro2024\/ee722-ispor-eu-2024-hcru-economic-rsv-burden-older-adults-in-eu5final142491-pdf.pdf?sfvrsn=1652f008_0"},{"key":"e_1_3_8_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiac069"},{"key":"e_1_3_8_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-026-01380-x"}],"container-title":["Journal of Medical Economics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13696998.2026.2746277","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/13696998.2026.2746277","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13696998.2026.2746277","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:32:13Z","timestamp":1792420333000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13696998.2026.2746277"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,19]]},"references-count":75,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"alternative-id":["10.1080\/13696998.2026.2746277"],"URL":"https:\/\/doi.org\/10.1080\/13696998.2026.2746277","relation":{},"ISSN":["1369-6998","1941-837X"],"issn-type":[{"value":"1369-6998","type":"print"},{"value":"1941-837X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,19]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ijme20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ijme20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-08-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}