{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T01:12:20Z","timestamp":1793841140945,"version":"4.6.1"},"reference-count":48,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T00:00:00Z","timestamp":1481500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This research was funded by the Tunisian Ministry of Higher Education and Scientific Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, Tunisia."}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Pharmaceutical Biology"],"published-print":{"date-parts":[[2017,1]]},"DOI":"10.1080\/13880209.2016.1255976","type":"journal-article","created":{"date-parts":[[2016,12,19]],"date-time":"2016-12-19T03:05:45Z","timestamp":1482116745000},"page":"516-525","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":46,"title":["Phytochemical, antioxidant and protective effect of cactus cladodes extract against lithium-induced liver injury in rats"],"prefix":"10.1080","volume":"55","author":[{"given":"Anouar","family":"Ben Saad","sequence":"first","affiliation":[{"name":"Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, University of Gafsa, Gafsa, Tunisia;"},{"name":"Research Unit of Active Biomolecules Valorisation, High Institute of Applied Biology of Medenine, University of Gabes, Medenine, Tunisia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brahmi","family":"Dalel","sequence":"additional","affiliation":[{"name":"Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, University of Gafsa, Gafsa, Tunisia;"},{"name":"Laboratory of Research on Biologically Compatible Compounds, Faculty of Dental Medicine, University of Monastir, Gafsa, Tunisia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhem","family":"Rjeibi","sequence":"additional","affiliation":[{"name":"Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, University of Gafsa, Gafsa, Tunisia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amani","family":"Smida","sequence":"additional","affiliation":[{"name":"Research Unit of Macromolecular Biochemistry and Genetics, Faculty of Sciences of Gafsa, University of Gafsa, Gafsa, Tunisia;"},{"name":"Research Unit of Active Biomolecules Valorisation, High Institute of Applied Biology of Medenine, University of Gabes, Medenine, Tunisia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Ncib","sequence":"additional","affiliation":[{"name":"Common Services Unit, Faculty of Sciences Gafsa, University of Gafsa, Gafsa, Tunisia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nacim","family":"Zouari","sequence":"additional","affiliation":[{"name":"High Institute of Applied Biology of Medenine, University of Gabes, Medenine, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lazhar","family":"Zourgui","sequence":"additional","affiliation":[{"name":"Research Unit of Active Biomolecules Valorisation, High Institute of Applied Biology of Medenine, University of Gabes, Medenine, Tunisia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,12,12]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05016-3"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.34.272"},{"key":"e_1_3_3_4_1","first-page":"7099","article-title":"Cactus (Opuntia ficus indica f. inermis) fruit juice protects against ethanol-induced hematological and biochemical damages in rats","volume":"12","author":"Alimi H","year":"2013","unstructured":"Alimi H, Hfaeidh N, Bouoni Z, Mbarki S, Sakly M, Ben Rhouma K. 2013. Cactus (Opuntia ficus indica f. inermis) fruit juice protects against ethanol-induced hematological and biochemical damages in rats. Afr J Biotechnol. 12:7099\u20137105.","journal-title":"Afr J Biotechnol"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2011.12.003"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2011.08.007"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/847320"},{"key":"e_1_3_3_8_1","first-page":"12","article-title":"Protective effect of cactus cladode extract against cisplatin induced oxidative stress, genotoxicity and apoptosis in balb\/c mice: combination with phytochemical composition","volume":"31","author":"Brahmi D","year":"2012","unstructured":"Brahmi D, Ayed Y, Hfaiedh M, Bouaziz C, Ben Mansour H, Zourgui L, Bacha H. 2012. Protective effect of cactus cladode extract against cisplatin induced oxidative stress, genotoxicity and apoptosis in balb\/c mice: combination with phytochemical composition. BMC Complement Altern Med. 31:12\u2013111.","journal-title":"BMC Complement Altern Med"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-8-73"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0115589"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/abbi.1994.1485"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(93)90307-P"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(84)05015-1"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.64.070195.000525"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2010.01.021"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.22048"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2008.09.059"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2373"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/41.5.929"},{"key":"e_1_3_3_20_1","first-page":"680","article-title":"Effects of lithium on oxidative stress parameters in healthy subjects","volume":"5","author":"Khairova R","year":"2012","unstructured":"Khairova R, Pawar R, Salvadore G, Juruena MF, Sousa RT, Soeiro-de-Souza MG, Salvador M, Zarate CA, Gattaz WF, Machado-Vieira R. 2012. Effects of lithium on oxidative stress parameters in healthy subjects. Mol Med Rep. 5:680\u2013682.","journal-title":"Mol Med Rep"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-014-9952-4"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-007-9092-9"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.21.9.1414"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(97)01510-9"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfoodeng.2004.10.036"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf020388c"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2007.11.002"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-5214(01)00160-0"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2014.11.010"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2010.08.031"},{"key":"e_1_3_3_31_1","first-page":"326","volume-title":"Pharmacology and therapeutics in the new millennium","author":"Narayana DB","year":"2000","unstructured":"Narayana DB, Dobriyalm RM. (2000). Complimentary medicines and 21st century therapeutics: challenges for pharmacologist. In: Gupta SK, editor. Pharmacology and therapeutics in the new millennium. New Delhi, India: Narosa Publishing House, pp. 326\u2013335."},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0144-8617(99)00032-6"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2007.08.047"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13105-011-0113-3"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(82)90338-0"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(79)90738-3"},{"key":"e_1_3_3_37_1","first-page":"109","article-title":"Lithium-induced renal toxicity in rats: protection by a novel antioxidant caffeic acid phenethyl ester","volume":"277","author":"Oktem F","year":"2005","unstructured":"Oktem F, Ozguner F, Sulak O, Olgar S, Akturk O, Yilmaz HR, Altuntas I. 2005. Lithium-induced renal toxicity in rats: protection by a novel antioxidant caffeic acid phenethyl ester. Mol Biol Cell. 277:109\u2013115.","journal-title":"Mol Biol Cell"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(95)02227-9"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.128.2.158"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2222-1808(12)60253-9"},{"key":"e_1_3_3_41_1","first-page":"1155","article-title":"Adverse effects of withdrawal of chronic lithium therapy on liver \u2013 a histological study","volume":"43","author":"Sharif N","year":"2011","unstructured":"Sharif N, Rabia A, Iftikhar O. 2011. Adverse effects of withdrawal of chronic lithium therapy on liver \u2013 a histological study. Pakistan J Zool. 43:1155\u20131160.","journal-title":"Pakistan J Zool"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.28.834"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf050636f"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-013-9629-4"},{"key":"e_1_3_3_45_1","first-page":"68","article-title":"Chemoprotective effect of sobatum against lithium-induced oxidative damage in rats","volume":"2","author":"Vijaimohan K","year":"2010","unstructured":"Vijaimohan K, Mallika J, Shyamala DC. 2010. Chemoprotective effect of sobatum against lithium-induced oxidative damage in rats. Pharmacology. 2:68\u201373.","journal-title":"Pharmacology"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.164.12.1334"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carres.2008.10.021"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf0103572"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2007.05.031"}],"container-title":["Pharmaceutical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13880209.2016.1255976","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13880209.2016.1255976","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T13:18:17Z","timestamp":1720099097000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13880209.2016.1255976"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,12]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1080\/13880209.2016.1255976"],"URL":"https:\/\/doi.org\/10.1080\/13880209.2016.1255976","relation":{},"ISSN":["1388-0209","1744-5116"],"issn-type":[{"value":"1388-0209","type":"print"},{"value":"1744-5116","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,12]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iphb20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iphb20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-05-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-10-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}