{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T12:26:09Z","timestamp":1787574369209,"version":"build-2736575974"},"reference-count":37,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"funder":[{"name":"the undergraduate innovation project of Sichuan Province Education Department","award":["201810634167"],"award-info":[{"award-number":["201810634167"]}]},{"name":"the undergraduate innovation project of Sichuan Province Education Department","award":["201810634168"],"award-info":[{"award-number":["201810634168"]}]},{"name":"the undergraduate innovation project of Sichuan Province Education Department","award":["201810634166"],"award-info":[{"award-number":["201810634166"]}]},{"name":"Applied Basic Research Programs of Science and Technology Department of Sichuan Province","award":["2016JY0032"],"award-info":[{"award-number":["2016JY0032"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Pharmaceutical Biology"],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1080\/13880209.2019.1645701","type":"journal-article","created":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T01:24:34Z","timestamp":1566523474000},"page":"477-484","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":11,"title":["Antidiarrheal activity of methanol extract of\n                    <i>Sophora tonkinensis<\/i>\n                    in mice and spasmolytic effect on smooth muscle contraction of isolated jejunum in rabbits"],"prefix":"10.1080","volume":"57","author":[{"given":"Yangyou","family":"Li","sequence":"first","affiliation":[{"name":"Animal Experimental Center, North Sichuan Medical College","place":["Nanchong City, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, North Sichuan Medical College","place":["Nanchong City, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, North Sichuan Medical College","place":["Nanchong City, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, North Sichuan Medical College","place":["Nanchong City, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Mei","sequence":"additional","affiliation":[{"name":"School of Pharmacy, North Sichuan Medical College","place":["Nanchong City, China"]},{"name":"Institute of Medicine, North Sichuan Medical College","place":["Nanchong City, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudan","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Pharmacy, North Sichuan Medical College","place":["Nanchong City, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology in School of Basic Medical Science, North Sichuan Medical College","place":["Nanchong City, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zheng","sequence":"additional","affiliation":[{"name":"Function Center in School of Basic Medical Science, North Sichuan Medical College","place":["Nanchong City, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shangjie","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine of Chinese and Western Medicine, North Sichuan Medical College","place":["Nanchong City, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,8,22]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.11.006"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5753"},{"key":"e_1_3_3_4_1","first-page":"119","article-title":"Analysis of TCM treatment mode for irritable bowel syndrome","volume":"8","author":"Bian LQ","year":"2015","unstructured":"Bian LQ, Chen T, Tang XD, Li ZH, Li BS, Zhang YQ, Wang P. 2015. Analysis of TCM treatment mode for irritable bowel syndrome. Global Chinese Med. 8:119\u2013123.","journal-title":"Global Chinese Med"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-827190"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(81)90334-5"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.14309\/00000434-200901001-00002"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b15-00680"},{"key":"e_1_3_3_9_1","volume-title":"Research methods in pharmacology of Chinese material medica","author":"Chen Q","year":"2011","unstructured":"Chen Q. 2011. Research methods in pharmacology of Chinese material medica. 3rd ed. Beijing: The People\u2019s Medical Publishing House.","edition":"3"},{"key":"e_1_3_3_10_1","first-page":"177","article-title":"Studies on the antibacterial activity of Sophora flavescens and total alkaloids of Sophora tonkinensis","volume":"18","author":"Dai WH","year":"2012","unstructured":"Dai WH, Qian LW, Yang SY, Zhou GQ, Wang LL. 2012. Studies on the antibacterial activity of Sophora flavescens and total alkaloids of Sophora tonkinensis. Chinese J Exp Trad Med Formulae. 18:177\u2013180.","journal-title":"Chinese J Exp Trad Med Formulae"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1993.tb07180.x"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2098"},{"key":"e_1_3_3_13_1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0031-6997(25)06867-X","article-title":"Calcium antagonism and Ca++ entry blockade","volume":"38","author":"Godfraind T","year":"1986","unstructured":"Godfraind T, Miller R, Wibo M. 1986. Calcium antagonism and Ca++ entry blockade. Pharmacol Rev. 38:321\u2013416.","journal-title":"Pharmacol Rev"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-016-1527-9"},{"key":"e_1_3_3_15_1","first-page":"639","article-title":"The role of Ca2+ in the contractility of rabbit small intestine in vitro","volume":"55","author":"Grasa L","year":"2004","unstructured":"Grasa L, Rebollar E, Arruebo MP, Plaza MA, Murillo MD. 2004. The role of Ca2+ in the contractility of rabbit small intestine in vitro. J Physiol Pharmacol. 55:639\u2013650.","journal-title":"J Physiol Pharmacol"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.04.043"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2013.879601"},{"key":"e_1_3_3_18_1","first-page":"114","article-title":"Pathogenesis of diarrhea predominant irritable bowel syndrome and research progress of Chinese medicine intervention","volume":"20","author":"Han YF","year":"2018","unstructured":"Han YF, Wang YL, Li JX. 2018. Pathogenesis of diarrhea predominant irritable bowel syndrome and research progress of Chinese medicine intervention. J Liaoning Univ Trad Chinese Med. 20:114\u2013117.","journal-title":"J Liaoning Univ Trad Chinese Med"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0079620"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00288"},{"key":"e_1_3_3_21_1","first-page":"137","article-title":"Study on active components alignment of antidiarrhea in Radix Puerariae","volume":"10","author":"Huang WQ","year":"2010","unstructured":"Huang WQ, Jin ZX, Zhang GJ, Liu N, Wen CX. 2010. Study on active components alignment of antidiarrhea in Radix Puerariae. Progr Mod Biomed. 10:137\u2013139.","journal-title":"Progr Mod Biomed"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/735653"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2015.4341"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2011.06641.x"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01234480"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-010-1466-0"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b00325"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-8741(02)00326-4"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107BOR-2015.vol29.0104"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-1696-1"},{"key":"e_1_3_3_31_1","first-page":"230","article-title":"Research progress in studies on toxicity of alkaloids in Sophora tonkinensis","volume":"22","author":"Tian X","year":"2016","unstructured":"Tian X. 2016. Research progress in studies on toxicity of alkaloids in Sophora tonkinensis. Chinese J Exper Trad Med Formulae. 22:230\u2013234.","journal-title":"Chinese J Exper Trad Med Formulae"},{"key":"e_1_3_3_32_1","first-page":"204","article-title":"Effectiveness of castor oil extract on Escherichia coli and its endotoxins in root canals","volume":"60","author":"Valera MC","year":"2012","unstructured":"Valera MC, Maekawa LE, Chung A, de Oliveira LD, Carvalho CA, Koga-Ito CY, Jorge AO. 2012. Effectiveness of castor oil extract on Escherichia coli and its endotoxins in root canals. Gen Dent. 60:204\u2013209.","journal-title":"Gen Dent"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2005.10.002"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.05.012"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.polymdegradstab.2006.10.011"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04376.x"},{"key":"e_1_3_3_37_1","first-page":"969","article-title":"A meta-analysis of the prevalence and risk factors of irritable bowel syndrome in Chinese community","volume":"53","author":"Zhang L","year":"2014","unstructured":"Zhang L, Duan L, Liu Y, Leng Y, Zhang H, Liu Z, Wang K. 2014. A meta-analysis of the prevalence and risk factors of irritable bowel syndrome in Chinese community. Chinese J Intern Med. 53:969\u2013975.","journal-title":"Chinese J Intern Med"},{"key":"e_1_3_3_38_1","first-page":"7","article-title":"Primary study of Rubus corchorifolius on antidiarrhetic mechanism","volume":"2","author":"Zhu SH","year":"2005","unstructured":"Zhu SH, Cao Y, Deng ZB. 2005. Primary study of Rubus corchorifolius on antidiarrhetic mechanism. J Trad Chinese Vet Med. 2:7\u201310.","journal-title":"J Trad Chinese Vet Med"}],"container-title":["Pharmaceutical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13880209.2019.1645701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/13880209.2019.1645701","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13880209.2019.1645701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:55:49Z","timestamp":1787572549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13880209.2019.1645701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,1]]}},"alternative-id":["10.1080\/13880209.2019.1645701"],"URL":"https:\/\/doi.org\/10.1080\/13880209.2019.1645701","relation":{},"ISSN":["1388-0209","1744-5116"],"issn-type":[{"value":"1388-0209","type":"print"},{"value":"1744-5116","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iphb20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iphb20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-10-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}