{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T12:26:16Z","timestamp":1787574376227,"version":"build-2736575974"},"reference-count":57,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"funder":[{"name":"National Innovative Drugs 13th Five-Year Major Special Project of China","award":["2018ZX09301030-002"],"award-info":[{"award-number":["2018ZX09301030-002"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Pharmaceutical Biology"],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1080\/13880209.2019.1653326","type":"journal-article","created":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T19:06:21Z","timestamp":1566759981000},"page":"555-563","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":32,"title":["Comparison of the TLR4\/NF\u03baB and NLRP3 signalling pathways in major organs of the mouse after intravenous injection of lipopolysaccharide"],"prefix":"10.1080","volume":"57","author":[{"given":"Qin","family":"Gong","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences, Jiangxi University of Traditional Chinese Medicine","place":["Nanchang, China"]},{"name":"State Key Laboratory of Innovative Drugs and Efficient Energy-saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luling","family":"He","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Innovative Drugs and Efficient Energy-saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mulan","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Innovative Drugs and Efficient Energy-saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shasha","family":"Zuo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Innovative Drugs and Efficient Energy-saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Gao","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Guangxi University of Chinese Medicine","place":["Nanning, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Jiangxi University of Traditional Chinese Medicine","place":["Nanchang, China"]},{"name":"State Key Laboratory of Innovative Drugs and Efficient Energy-saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Du","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Innovative Drugs and Efficient Energy-saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine","place":["Nanchang, China"]},{"name":"College of Pharmacy, Guangxi University of Chinese Medicine","place":["Nanning, China"]},{"name":"School of Life Sciences, Tsinghua University","place":["Beijing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Luo","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Jiangxi University of Traditional Chinese Medicine","place":["Nanchang, China"]},{"name":"State Key Laboratory of Innovative Drugs and Efficient Energy-saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences, Jiangxi University of Traditional Chinese Medicine","place":["Nanchang, China"]},{"name":"State Key Laboratory of Innovative Drugs and Efficient Energy-saving Pharmaceutical Equipment, Jiangxi University of Traditional Chinese Medicine","place":["Nanchang, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,8,25]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2018.08.009"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/SHK.0b013e31823f146f"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.09.022"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090850"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.16.10689"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddiscovery.2016.19"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112256"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-031210-101405"},{"issue":"6","key":"e_1_3_3_10_1","first-page":"3353","article-title":"Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury","volume":"41","author":"Dong ZW","year":"2018","unstructured":"Dong ZW, Yuan YF. 2018. Juglanin suppresses fibrosis and inflammation response caused by LPS in acute lung injury. Int J Mol Med. 41(6):3353\u20133365.","journal-title":"Int J Mol Med"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00378.2002"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0701-z"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(13)70976-9"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14488"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.280.5.G930"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25930"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.08.023"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.4.2251"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2018.08.015"},{"key":"e_1_3_3_20_1","first-page":"302","article-title":"Dexmedetomidine inhibits inflammation in microglia cells under stimulation of LPS and ATP by C-FOS\/NLRP3\/Caspase1 cascades","volume":"17","author":"Li H","year":"2018","unstructured":"Li H, Zhang X, Chen M, Chen J, Gao T, Yao S. 2018. Dexmedetomidine inhibits inflammation in microglia cells under stimulation of LPS and ATP by C-FOS\/NLRP3\/Caspase1 cascades. Excli J. 17:302\u2013311.","journal-title":"Excli J"},{"issue":"6","key":"e_1_3_3_21_1","first-page":"7618","article-title":"Dynamic expression and roles of sequestome\u20111\/p62 in LPS\u2011induced acute kidney injury in mice","volume":"17","author":"Li T","year":"2018","unstructured":"Li T, Zhao J, Miao S, Xu Y, Xiao X, Liu Y. 2018. Dynamic expression and roles of sequestome\u20111\/p62 in LPS\u2011induced acute kidney injury in mice. Mol Med Rep. 17(6):7618\u20137626.","journal-title":"Mol Med Rep"},{"key":"e_1_3_3_22_1","first-page":"2871","article-title":"Effect of paeoniflorin on oxidative stress and energy metabolism in mice with lipopolysaccharide (LPS)-induced brain injury","volume":"40","author":"Liu L","year":"2015","unstructured":"Liu L, Qiu XJ, He SN, Yang H, Wang D, Yang XM. 2015. Effect of paeoniflorin on oxidative stress and energy metabolism in mice with lipopolysaccharide (LPS)-induced brain injury. J Chin Mater Med. 40:2871\u20132875.","journal-title":"J Chin Mater Med"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2016.00019"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.97"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-018-05764-z"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2014.12.013"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)75971-7"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00763.2001"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2018.07.013"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161210790883516"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)41963-6"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623318776898"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.4149\/gpb_2012_031"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.02.016"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)50501-9"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22101683"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.08.087"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.04.028"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)68262-6"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0056526"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2004.07.008"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134044"},{"issue":"3","key":"e_1_3_3_43_1","first-page":"410","article-title":"Lipopolysaccharide decreasing albumin expression in rat hepatocytes","volume":"4","author":"Wang XY","year":"2005","unstructured":"Wang XY, Li WQ, Lu J, Li N, Li JS. 2005a. Lipopolysaccharide decreasing albumin expression in rat hepatocytes. HBPD Int. 4(3):410\u2013415.","journal-title":"HBPD Int"},{"key":"e_1_3_3_44_1","first-page":"1695","article-title":"Mechanism of reduction of albumin expression induced by lipopolysaccharide in rat hepatocytes","volume":"118","author":"Wang XY","year":"2005","unstructured":"Wang XY, Li WQ, Lu J, Li N, Li JS. 2005b. Mechanism of reduction of albumin expression induced by lipopolysaccharide in rat hepatocytes. Chinese Med J. 118:1695\u20131702.","journal-title":"Chinese Med J"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01728"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2018.08.016"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-014-1997-3"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2017.02.017"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-017-0526-9"},{"key":"e_1_3_3_50_1","first-page":"4861","article-title":"Intestinal macrophages involved in the homeostasis of the intestine have the potential for responding to LPS","volume":"29","author":"Yoshioka N","year":"2009","unstructured":"Yoshioka N, Taniguchi Y, Yoshida A, Nakata K, Nishizawa T, Inagawa H, Kohchi C, Soma GI. 2009. Intestinal macrophages involved in the homeostasis of the intestine have the potential for responding to LPS. Anticancer Res. 29:4861\u20134865.","journal-title":"Anticancer Res"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2018.02.007"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep18326"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.12.7611"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-018-0777-8"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.04.005"},{"issue":"4","key":"e_1_3_3_56_1","first-page":"5463","article-title":"NLRP1 and NLRP3 inflammasomes mediate LPS\/ATP\u2011induced pyroptosis in knee osteoarthritis","volume":"17","author":"Zhao LR","year":"2018","unstructured":"Zhao LR, Xing RL, Wang PM, Zhang NS, Yin SJ, Li XC, Zhang L. 2018. NLRP1 and NLRP3 inflammasomes mediate LPS\/ATP\u2011induced pyroptosis in knee osteoarthritis. Mol Med Rep. 17(4):5463\u20135469.","journal-title":"Mol Med Rep"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0372-z"},{"key":"e_1_3_3_58_1","first-page":"263","article-title":"Immunohistochemical study of tumor necrosis factor-alpha expression in the lungs and small intestines in hyperthermia-LPS co-stressed rats","volume":"30","author":"Zuo D","year":"2010","unstructured":"Zuo D, Zhou WM, Guo BB., Mei GP 2010. Immunohistochemical study of tumor necrosis factor-alpha expression in the lungs and small intestines in hyperthermia-LPS co-stressed rats. J Southern Med Univ. 30:263\u2013265.","journal-title":"J Southern Med Univ"}],"container-title":["Pharmaceutical Biology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13880209.2019.1653326","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/13880209.2019.1653326","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/13880209.2019.1653326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T11:56:14Z","timestamp":1787572574000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/13880209.2019.1653326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,1]]}},"alternative-id":["10.1080\/13880209.2019.1653326"],"URL":"https:\/\/doi.org\/10.1080\/13880209.2019.1653326","relation":{},"ISSN":["1388-0209","1744-5116"],"issn-type":[{"value":"1388-0209","type":"print"},{"value":"1744-5116","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iphb20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iphb20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-25","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}