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Complete ovarian function was assessed during the early follicular phase of the menstrual cycle including anti-M\u00fcllerian hormone (AMH), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and antral follicle count (AFC) by ovarian ultrasound, and anti-corpus lutheum antibodies (anti-CoL). Demographic data, menstrual abnormalities, disease parameters and treatment were also evaluated.<\/jats:p>\n                  <jats:p>Results: The mean current age (22.6\u2009\u00b1\u20096.59 vs. 22.5\u2009\u00b1\u20096.59 years, p\u2009=\u2009.952) was similar in JIA patients and healthy controls with a higher median menarche age [13(8\u201316) vs. 12(8\u201314) years, p\u2009=\u2009.029]. A lower median AMH levels [2.65(0.47\u20139.08) vs. 4.83(0.74\u201317.24) ng\/mL, p\u2009=\u2009.029] with a higher LH [8.44\u2009\u00b1\u20094.14 vs. 6.03\u2009\u00b1\u20092.80\u2009IU\/L, p\u2009=\u2009.014] and estradiol levels [52.3(25.8\u2013227.4) vs. 38.9(26.2\u2013133.6) pg\/mL, p\u2009=\u2009.008] were observed in JIA compared to control group. Anti-CoL and AFC were similar in both groups (p\u2009&amp;gt;\u2009.05). Further analysis of JIA patients revealed that current age, disease duration, number of active\/limited joints, ESR, CRP, patient\/physician VAS, JADAS 71, DAS 28, CHAQ, HAQ, patient\/parents PedsQL, PF-SF 36, cumulative glucocorticoid and cumulative methotrexate doses were not correlated with AMH, FSH, estradiol levels or AFC (p\u2009&amp;gt;\u2009.05).<\/jats:p>\n                  <jats:p>Conclusion: The present study was the first to suggest diminished ovarian reserve, not associated to hypothalamic pituitary gonadal axis, in JIA patients during reproductive age. The impact of this dysfunction in future fertility of these patients needs to be evaluated in prospective studies.<\/jats:p>","DOI":"10.1080\/14397595.2018.1465646","type":"journal-article","created":{"date-parts":[[2018,4,13]],"date-time":"2018-04-13T09:03:36Z","timestamp":1523610216000},"page":"447-451","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":18,"title":["Ovarian reserve in young juvenile idiopathic arthritis patients"],"prefix":"10.1093","volume":"29","author":[{"given":"Gabriela R V","family":"Ferreira","sequence":"first","affiliation":[{"name":"Pediatric Rheumatology Unit, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de S\u00e3o Paulo , Sao Paulo, ;","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato B","family":"Tomioka","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da 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;","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo A R","family":"Maciel","sequence":"additional","affiliation":[{"name":"Discipline of Gynecology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de S\u00e3o Paulo , Sao Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo C","family":"Serafini","sequence":"additional","affiliation":[{"name":"Discipline of Gynecology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de S\u00e3o Paulo , Sao Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund C","family":"Baracat","sequence":"additional","affiliation":[{"name":"Discipline of Gynecology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de S\u00e3o Paulo , Sao Paulo,","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Goldenstein-Schainberg","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de S\u00e3o Paulo , Sao Paulo, ;","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M R","family":"Pereira","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de S\u00e3o Paulo , Sao Paulo, ;","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloisa","family":"Bonf\u00e1","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Hospital das Clinicas HCFMUSP, Faculdade de Medicina da Universidade de S\u00e3o Paulo , Sao Paulo, ;","place":["Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clovis 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