{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:20:23Z","timestamp":1780467623280,"version":"3.54.1"},"reference-count":83,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Pharmacotherapy"],"published-print":{"date-parts":[[2020,2,11]]},"DOI":"10.1080\/14656566.2019.1702970","type":"journal-article","created":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T04:24:06Z","timestamp":1577939046000},"page":"353-363","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":69,"title":["PCSK9 inhibitors for treating hypercholesterolemia"],"prefix":"10.1080","volume":"21","author":[{"given":"Andrea","family":"Pasta","sequence":"first","affiliation":[{"name":"Department of Internal Medicine (DIMI), University of Genoa, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Laura","family":"Cremonini","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (DIMI), University of Genoa, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Livia","family":"Pisciotta","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (DIMI), University of Genoa, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Buscaglia","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (DIMI), University of Genoa, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Italo","family":"Porto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (DIMI), University of Genoa, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Barra","sequence":"additional","affiliation":[{"name":"Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genova, Italy"},{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Ferrero","sequence":"additional","affiliation":[{"name":"Academic Unit of Obstetrics and Gynecology, IRCCS Ospedale Policlinico San Martino, Genova, Italy"},{"name":"Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), University of Genoa, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Brunelli","sequence":"additional","affiliation":[{"name":"Clinic of Cardiovascular Diseases, University of Genoa, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Marco","family":"Rosa","sequence":"additional","affiliation":[{"name":"Clinic of Cardiovascular Diseases, University of Genoa, Genova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,1,1]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31833-0"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu208"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-143-11-200512060-00006"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.072"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajem.2013.09.030"},{"key":"CIT0006","first-page":"w13797","volume":"143","author":"Valbusa A","year":"2013","journal-title":"Swiss Med Wkly"},{"issue":"11","key":"CIT0007","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.recesp.2012.04.016","volume":"65","author":"N\u00fa\u00f1ez-Gil IJ","year":"2012","journal-title":"Rev Esp Cardiol (Engl Ed)"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-1-85"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcp065"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx144"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.80"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2015.92"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67394-1"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12255"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/suw009"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.001"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.01.001"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0358-8"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw388"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1358\/dof.2013.038.07.1981967"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.2217\/fca.13.107"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1615664"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801174"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-018-0718-x"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.023687"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1097\/MED.0000000000000137"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.07.910"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-1028-6"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.6803"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M051326"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23112"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.09.010"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.P065334"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2015.1075506"},{"issue":"43","key":"CIT0047","first-page":"2996","volume":"36","author":"Kastelein JJ","year":"2015","journal-title":"Eur Heart J"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1007\/s10557-016-6685-y"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2015.03.004"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.06.023"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1501031"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacl.2015.08.006"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.2217\/fca.14.82"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1520"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2015.11.010"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2016.08.043"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.003421"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1316222"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.018"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61399-4"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.4030"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61374-X"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.03.019"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2015.10.021"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.3608"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1500858"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(19)32321-6"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-015-0358-8"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.006910"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-018-0439-8"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(16)00003-6"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1002\/clc.23049"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1007\/s11883-019-0773-y"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038840"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.043826"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosissup.2017.05.030"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.13066"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.7326\/M14-2957"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.3892\/br.2016.766"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.025233"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2017.07.047"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(17)30313-3"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(19)30158-5"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32290-0"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx661"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1701131"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2005.01.001"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1614062"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1701488"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2015.1051619"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2017.0747"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.08.036"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1616623"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307071"}],"container-title":["Expert Opinion on Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14656566.2019.1702970","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,22]],"date-time":"2020-02-22T11:34:40Z","timestamp":1582371280000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14656566.2019.1702970"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,1]]},"references-count":83,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,2,11]]}},"alternative-id":["10.1080\/14656566.2019.1702970"],"URL":"https:\/\/doi.org\/10.1080\/14656566.2019.1702970","relation":{},"ISSN":["1465-6566","1744-7666"],"issn-type":[{"value":"1465-6566","type":"print"},{"value":"1744-7666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieop20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieop20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-09-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}