{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:24:03Z","timestamp":1789698243859,"version":"4.0.1"},"reference-count":93,"publisher":"Informa UK Limited","issue":"2","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Pharmacotherapy"],"published-print":{"date-parts":[[2026,1,22]]},"DOI":"10.1080\/14656566.2026.2637587","type":"journal-article","created":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T22:14:49Z","timestamp":1772748889000},"page":"123-133","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":2,"title":["Progress, potential and pitfalls of ketamine as a treatment for depression"],"prefix":"10.1080","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6641-0057","authenticated-orcid":false,"given":"Diana K.","family":"Orsini","sequence":"first","affiliation":[{"name":"University Health Network","place":["Toronto, Canada"]},{"name":"University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7662-5882","authenticated-orcid":false,"given":"Sara","family":"Di Luch","sequence":"additional","affiliation":[{"name":"University Health Network","place":["Toronto, Canada"]},{"name":"University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8403-5206","authenticated-orcid":false,"given":"Gabrielle F. M.","family":"Lovell","sequence":"additional","affiliation":[{"name":"University Health Network","place":["Toronto, Canada"]},{"name":"University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4773-2191","authenticated-orcid":false,"given":"Joshua D.","family":"Rosenblat","sequence":"additional","affiliation":[{"name":"University Health Network","place":["Toronto, Canada"]},{"name":"University of Toronto","place":["Toronto, Canada"]},{"name":"University of Toronto","place":["Toronto, Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,3,3]]},"reference":[{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-023-00454-1"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.21120"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2023.102127"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-023-01629-w"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2018.18020138"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0503-4"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20240378"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-025-03800-w"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00230-9"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.05.003"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.8.856"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20081251"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2302399"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2025.3019"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s44220-023-00140-x"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20240515"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.3555"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2304145"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11414-025-09975-x"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2023.11.002"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2025.1317"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2021.09.002"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2025.1512429"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2022.04.037"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2836"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2025.116691"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.25m15831"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2025.116647"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2020.1776699"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20240655"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.13m08852"},{"key":"e_1_3_3_34_1","unstructured":"Summary safety review - ketamine - assessing the potential risk of liver and bile duct damage [internet]. [cited 2025 Dec 23]. Available from: https:\/\/dhpp.hpfb-dgpsa.ca\/review-documents\/resource\/SSR00239"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2025.01.054"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-023-01732-5"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2022.04.035"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-024-02973-1"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.25m15789"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.03.026"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadr.2025.100954"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1037\/pha0000627"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-024-06448-x"},{"key":"e_1_3_3_44_1","unstructured":"Research C for DE and. FDA alerts health care professionals of potential risks associated with compounded ketamine nasal spray. FDA; 2022 [cited 2025 Nov 17]."},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2023.2169349"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.19f12820"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-016-0383-6"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.2165\/11599770-000000000-00000"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03063-x"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.4103\/0253-7176.127258"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/acps.12572"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.784830"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-022-04268-5"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0256-5"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000001839"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.12.019"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/07067437241245384"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/0004867420952543"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40345-023-00308-5"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0365-0"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2025.0200"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyab039"},{"key":"e_1_3_3_63_1","unstructured":"Schatzberg A. Opiate suicide study in patients with major depression [internet]. Report No.: nCT04116528. Available from clinicaltrials.gov; 2025 [cited 2025 Dec 23]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT04116528"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.2147\/JPR.S360733"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1159\/000517074"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20220216"},{"key":"e_1_3_3_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2023.1268832"},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881120959644"},{"key":"e_1_3_3_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)01116-3"},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-198003000-00008"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/57.2.197"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12102283"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.116.239228"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.136"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pbb.2013.11.033"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(94)00170-J"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2019.11.086"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(96)00042-9"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-020-01110-5"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.02.151"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2023.06.028"},{"key":"e_1_3_3_82_1","unstructured":"Perception Neuroscience. A randomized placebo-controlled double-blind study to assess safety and efficacy of intravenous PCN-101 in treatment resistant depression [Internet]. Report No.: nCT05414422. Available from clinicaltrials.gov; 2024 [cited 2025 Dec 23]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT05414422"},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1177\/20451253231202723"},{"key":"e_1_3_3_84_1","unstructured":"Study details | NCT05004896 | ketamine for treatment-resistant bipolar disorder. ClinicalTrials.gov; [cited 2025 Nov 11]. Available from: https:\/\/www.clinicaltrials.gov\/study\/NCT05004896?id=NCT06927076 NCT05339074 NCT05004896&rank=3"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2023.115133"},{"key":"e_1_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-023-01540-4"},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.36131\/cnfioritieditore20240102"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20050596"},{"key":"e_1_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.1097\/HRP.0000000000000330"},{"key":"e_1_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.1177\/02698811241301215"},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-0844-4"},{"key":"e_1_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0317-8"},{"key":"e_1_3_3_93_1","doi-asserted-by":"publisher","DOI":"10.3109\/10601331003777444"},{"key":"e_1_3_3_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2003.10.016"},{"key":"e_1_3_3_95_1","doi-asserted-by":"publisher","DOI":"10.1177\/1740774512465064"}],"container-title":["Expert Opinion on Pharmacotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14656566.2026.2637587","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T11:47:47Z","timestamp":1773402467000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14656566.2026.2637587"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,22]]},"references-count":93,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1,22]]}},"alternative-id":["10.1080\/14656566.2026.2637587"],"URL":"https:\/\/doi.org\/10.1080\/14656566.2026.2637587","relation":{},"ISSN":["1465-6566","1744-7666"],"issn-type":[{"value":"1465-6566","type":"print"},{"value":"1744-7666","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,22]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieop20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieop20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}