{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:39:46Z","timestamp":1790257186028,"version":"4.1.0"},"reference-count":116,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Emerging Drugs"],"published-print":{"date-parts":[[2016,7,2]]},"DOI":"10.1080\/14728214.2016.1220537","type":"journal-article","created":{"date-parts":[[2016,8,18]],"date-time":"2016-08-18T09:51:44Z","timestamp":1471513904000},"page":"315-330","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":8,"title":["Emerging drugs for the treatment of kidney disease-induced anemia"],"prefix":"10.1080","volume":"21","author":[{"given":"Jolanta","family":"Malyszko","sequence":"first","affiliation":[{"name":",","place":["Poland"]},{"name":",","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacek S.","family":"Malyszko","sequence":"additional","affiliation":[{"name":",","place":["Poland"]},{"name":",","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2016,8,22]]},"reference":[{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199592548.003.0125"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.15.8705"},{"key":"e_1_3_2_5_1","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1182\/blood.V73.4.952.952","article-title":"Characterization of the potentiation effect of activin on human erythroid colony formation in vitro","volume":"73","author":"Yu J","year":"1989","unstructured":"Yu J, Shao L, Vaughan J, et al. Characterization of the potentiation effect of activin on human erythroid colony formation in vitro. Blood. 1989;73:952\u2013960.","journal-title":"Blood"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3524"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3468"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.087361"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1992.72.2.449"},{"key":"e_1_3_2_10_1","first-page":"399","article-title":"Regulation of erythropoietin production","volume":"21","author":"Porter DL","year":"1993","unstructured":"Porter DL, Goldberg MA. Regulation of erythropoietin production. Exp Hematol. 1993;21:399\u2013404.","journal-title":"Exp Hematol"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.201.8.1197"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.12.12.5447-5454.1992"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1011165"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01920-7"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M008922200"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2016.02.001"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000098522"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200318181"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M202653200"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000017223.49823.2A"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1066373"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00507-4"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V92.7.2260"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2011.566861"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm400386j"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808273390903"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa065485"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa062276"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907845"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.09131209"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.22.7580"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/kisup.2012.37"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/468018a"},{"key":"e_1_3_2_34_1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.4103\/2229-3485.71840","article-title":"Regulatory considerations for biosimilars","volume":"1","author":"Nellore R","year":"2010","unstructured":"Nellore R. Regulatory considerations for biosimilars. Perspect Clin Res. 2010;1:11\u201314.","journal-title":"Perspect Clin Res"},{"key":"e_1_3_2_35_1","first-page":"221","article-title":"Erythropoietic factors in renal chronic disease: economic management","volume":"34","author":"Lopez MJ","year":"2012","unstructured":"Lopez MJ, Antonino G, Vicente I, et al. Erythropoietic factors in renal chronic disease: economic management. Int J Clin Pharm. 2012;34:221\u2013222.","journal-title":"Int J Clin Pharm"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40258-014-0125-6"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1098-3015(10)70958-X"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2016.01.011"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr024"},{"key":"e_1_3_2_40_1","first-page":"1","article-title":"Investigational therapies for renal disease-induced anemia","volume":"21","author":"Schmid H","year":"2016","unstructured":"Schmid H, Jelkmann W. Investigational therapies for renal disease-induced anemia. Expert Opin Investig Drugs. 2016;21:1\u201316.","journal-title":"Expert Opin Investig Drugs"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.06.030"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/med\/9780199592548.003.0125"},{"key":"e_1_3_2_43_1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1177\/108155899904700506","article-title":"Inhibition of CFU-E colony formation in uremic patients with inflammatory disease: role of IFN-gamma and TNF-alpha","volume":"47","author":"Allen DA","year":"1999","unstructured":"Allen DA, Breen C, Yaqoob MM, et al. Inhibition of CFU-E colony formation in uremic patients with inflammatory disease: role of IFN-gamma and TNF-alpha. J Investig Med. 1999;47:204\u2013211.","journal-title":"J Investig Med"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(04)01086-8"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2004.08.042"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.295"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1005109"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3855"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010010116"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv302"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002480-199407000-00122"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.59.2.360"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06890615"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI31370"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.12.012"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.238667"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015030241"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.12.020"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111838"},{"key":"e_1_3_2_60_1","doi-asserted-by":"crossref","unstructured":"Macdougall I Akizawa T Berns J et al. Safety and efficacy of molidustat in erythropoiesis stimulating agents (esa) pre-treated anaemic patients with chronic kidney disease not on dialysis (ckd-nd). 53rd Congress ERA-EDTA; 2016 May 21\u201324; Vienna. abstract Sp309.","DOI":"10.1093\/ndt\/gfw166.01"},{"key":"e_1_3_2_61_1","doi-asserted-by":"crossref","unstructured":"Macdougall I Akizawa T Berns J et al. Molidustat increases haemoglobin in erythropoiesis stimulating agents (esa)-naive anaemic patients with chronic kidney disease not on dialysis (ckd-nd). 53rd Congress ERA-EDTA; 2016 May 21\u201324; Vienna. abstract So036.","DOI":"10.1093\/ndt\/gfw123.04"},{"key":"e_1_3_2_62_1","unstructured":"http:\/\/ir.akebia.com\/releasedetail.cfm?releaseid=972288"},{"key":"e_1_3_2_63_1","unstructured":"http:\/\/ir.akebia.com\/releasedetail.cfm?ReleaseID5878191"},{"key":"e_1_3_2_64_1","doi-asserted-by":"crossref","unstructured":"Chandorkar GA Farzaneh-Far R Buch A et al. A drug-drug interaction study to evaluate the effect of vadadustat on the pharmacokinetics of celecoxib a cyp2c9 substrate in healthy volunteers. 53rd Congress ERA-EDTA; 2016 May 21\u201324; Vienna. abstract SP322.","DOI":"10.1093\/ndt\/gfw166.14"},{"key":"e_1_3_2_65_1","unstructured":"http:\/\/ir.akebia.com\/releasedetail.cfm?releaseid=935299"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.11.021"},{"key":"e_1_3_2_67_1","unstructured":"Safety tolerability PK and PD study of JTZ-951 in anemic subjects with end-stage renal disease. U.S. National Institutes of Health. Available from: https:\/\/clinicaltrials.gov\/ct2\/show?term5jtz-951&rank52."},{"key":"e_1_3_2_68_1","unstructured":"Pilot PK\/PD study of DS-1093a in patients with chronic kidney disease. U.S. National Institutes of Health. Available from: https:\/\/clinicaltrials.gov\/ct2\/show?term5ds1093a&rank51."},{"key":"e_1_3_2_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/1744-9987.12164"},{"key":"e_1_3_2_70_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.12067"},{"key":"e_1_3_2_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02182.x"},{"key":"e_1_3_2_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2009.21"},{"key":"e_1_3_2_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01075997"},{"key":"e_1_3_2_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft269"},{"key":"e_1_3_2_75_1","unstructured":"Affymax and Takeda announce a nationwide voluntary recall of all lots of OMONTYS (peginesatide) Injection. Available from: http:\/\/www.takeda.com\/news\/2013\/20130224_5664.html."},{"key":"e_1_3_2_76_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-1134fje"},{"key":"e_1_3_2_77_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075568"},{"key":"e_1_3_2_78_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-04-1631"},{"key":"e_1_3_2_79_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-11-4174"},{"key":"e_1_3_2_80_1","doi-asserted-by":"publisher","DOI":"10.1177\/0091270008322907"},{"key":"e_1_3_2_81_1","doi-asserted-by":"publisher","DOI":"10.2165\/11317190-000000000-00000"},{"key":"e_1_3_2_82_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-172320"},{"key":"e_1_3_2_83_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-511238"},{"key":"e_1_3_2_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3512"},{"key":"e_1_3_2_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.160"},{"key":"e_1_3_2_86_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23732"},{"key":"e_1_3_2_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.01.370"},{"key":"e_1_3_2_88_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0024574"},{"key":"e_1_3_2_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-012-0500-5"},{"key":"e_1_3_2_90_1","unstructured":"http:\/\/genexine.com\/m62.php?cate=1 [cited 2016 May 29]."},{"key":"e_1_3_2_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3814"},{"key":"e_1_3_2_92_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-09-245977"},{"key":"e_1_3_2_93_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-505792"},{"key":"e_1_3_2_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23110"},{"key":"e_1_3_2_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.03.012"},{"key":"e_1_3_2_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.12.094"},{"key":"e_1_3_2_97_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-584607"},{"key":"e_1_3_2_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.09.004"},{"key":"e_1_3_2_99_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-03-559484"},{"key":"e_1_3_2_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(04)03294-5"},{"key":"e_1_3_2_101_1","unstructured":"Pieris. Preclinical Pipeline PRS-080. [cited 2016 May 29]. Available from: http:\/\/www.pieris.com\/pipeline\/proprietary-programs\/prs-080."},{"key":"e_1_3_2_102_1","unstructured":"http:\/\/www.pieris.com\/news-and-events\/press-releases\/detail\/524\/ [cited 2016 May 29]."},{"key":"e_1_3_2_103_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V1061274"},{"key":"e_1_3_2_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/17.2.265"},{"key":"e_1_3_2_105_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014020212"},{"key":"e_1_3_2_106_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014080842"},{"key":"e_1_3_2_107_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737167.2015.995169"},{"key":"e_1_3_2_108_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.jrn.2014.03.006"},{"key":"e_1_3_2_109_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.10.014"},{"key":"e_1_3_2_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2014.58"},{"key":"e_1_3_2_111_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv006"},{"key":"e_1_3_2_112_1","first-page":"1","article-title":"Iron-based phosphate binders \u2013 a new element in management of hyperphosphatemia","volume":"16","author":"Pai AB","year":"2015","unstructured":"Pai AB, Jang SM, Wegrzyn N. Iron-based phosphate binders \u2013 a new element in management of hyperphosphatemia. Expert Opin Drug Metab Toxicol. 2015;16:1\u201313.","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"e_1_3_2_113_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.00436.x"},{"key":"e_1_3_2_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.203"},{"key":"e_1_3_2_115_1","doi-asserted-by":"publisher","DOI":"10.1097\/JIM.0000000000000206"},{"key":"e_1_3_2_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2012.08.001"},{"key":"e_1_3_2_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.68"},{"key":"e_1_3_2_118_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2008.12.010"}],"container-title":["Expert Opinion on Emerging Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14728214.2016.1220537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T16:24:22Z","timestamp":1770913462000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14728214.2016.1220537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,2]]},"references-count":116,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,7,2]]}},"alternative-id":["10.1080\/14728214.2016.1220537"],"URL":"https:\/\/doi.org\/10.1080\/14728214.2016.1220537","relation":{},"ISSN":["1472-8214","1744-7623"],"issn-type":[{"value":"1472-8214","type":"print"},{"value":"1744-7623","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemd20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iemd20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2016-05-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}