{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:39:29Z","timestamp":1790393969812,"version":"4.1.0"},"reference-count":119,"publisher":"Informa UK Limited","issue":"5","funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81622030"],"award-info":[{"award-number":["81622030"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Fundamental Research Funds of Shandong University","award":["2016JC023"],"award-info":[{"award-number":["2016JC023"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Targets"],"published-print":{"date-parts":[[2019,5,4]]},"DOI":"10.1080\/14728222.2019.1601702","type":"journal-article","created":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T09:58:27Z","timestamp":1554112707000},"page":"437-446","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":61,"title":["TANK-binding kinase 1 as a novel therapeutic target for viral diseases"],"prefix":"10.1080","volume":"23","author":[{"given":"Chunyuan","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Immunology, School of Basic Medical Science, Shandong University, Jinan, China"},{"name":"State Key Laboratory of Microbial Technology, Shandong University, Jinan, China"},{"name":"Department of Cell Biology, School of Basic Medical Science, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Basic Medical Science, Shandong University, Jinan, China"},{"name":"State Key Laboratory of Microbial Technology, Shandong University, Jinan, China"},{"name":"Department of Cell Biology, School of Basic Medical Science, Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.23.6694"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1038\/35008109"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80445-1"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1126\/science.1081315"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1038\/ni921"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20040520"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.01.034"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601773"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-012-2929-1"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700017200"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.23.21.7780-7793.2003"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601743"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203155"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0043756"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700699"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110474200"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121552109"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2015.8"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.05.006"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1038\/nri1604"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gene.6364449"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1038\/35099560"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093616"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1126\/science.1093620"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1038\/ni1087"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.5.2851"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.012"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.06.041"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01471-07"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1038\/nature06042"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.06.015"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.05.004"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1038\/nature10429"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1126\/science.1232458"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1126\/science.1229963"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1038\/nature08476"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2016.12.004"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.04.015"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2002355"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2475"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700376"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.06.020"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.11.021"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2016.27"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201694060"},{"key":"CIT0046","volume":"10","author":"Li X","year":"2017","journal-title":"Sci Signal"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2012.06.017"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1403083"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01118-18"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005179"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2017.05.010"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2239"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20120024"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2015.108"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20170180"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2016.08.029"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.01.033"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3588"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1742"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.109819"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.06.014"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1302634"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2008.136"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3422"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.10.008"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3464"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1615287113"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mjv068"},{"key":"CIT0069","doi-asserted-by":"crossref","DOI":"10.1128\/MCB.00537-16","volume":"37","author":"Bist P","year":"2017","journal-title":"Mol Cell Biol"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1600039"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.09.006"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1301601"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2010.103"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100963"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1159\/000489832"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1601194"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900818106"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006328"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.03.001"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.01.010"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300798"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100719"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600863"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.440859"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-018-0057-4"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006347"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12038"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.01.052"},{"key":"CIT0089","first-page":"2:e00234-17","author":"Rezelj VV","year":"2017","journal-title":"mSphere"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00553-15"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.805127"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03510-13"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1093\/jmcb\/mju015"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00706-18"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00889-15"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02589-10"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2008.294"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0017192"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201593458"},{"key":"CIT0100","volume":"92","author":"Liu X","year":"2018","journal-title":"J Virol"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2017.01.016"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00129-16"},{"key":"CIT0103","doi-asserted-by":"crossref","DOI":"10.3390\/v9010023","volume":"9","author":"Kang H","year":"2017","journal-title":"Viruses"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-014-0026-3"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00700-14"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03460-13"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2015.11.032"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-13-0646"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1172\/JCI75661"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3082"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.06.006"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv008"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.10.019"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.01.019"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2008.126"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.2"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-08-0276"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa2630"},{"key":"CIT0119","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan5861","volume":"10","author":"Jaishankar D","year":"2018","journal-title":"Sci Transl Med"}],"container-title":["Expert Opinion on Therapeutic Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14728222.2019.1601702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,27]],"date-time":"2019-04-27T22:27:17Z","timestamp":1556404037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14728222.2019.1601702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,10]]},"references-count":119,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,4]]},"published-print":{"date-parts":[[2019,5,4]]}},"alternative-id":["10.1080\/14728222.2019.1601702"],"URL":"https:\/\/doi.org\/10.1080\/14728222.2019.1601702","relation":{},"ISSN":["1472-8222","1744-7631"],"issn-type":[{"value":"1472-8222","type":"print"},{"value":"1744-7631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,10]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iett20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iett20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-09-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}