{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T01:19:33Z","timestamp":1772673573952,"version":"3.50.1"},"reference-count":122,"publisher":"Informa UK Limited","issue":"7","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Targets"],"published-print":{"date-parts":[[2019,7,3]]},"DOI":"10.1080\/14728222.2019.1626827","type":"journal-article","created":{"date-parts":[[2019,5,31]],"date-time":"2019-05-31T17:18:45Z","timestamp":1559323125000},"page":"593-606","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":13,"title":["A preclinical overview of emerging therapeutic targets for glomerular diseases"],"prefix":"10.1080","volume":"23","author":[{"given":"Paola","family":"Cassis","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCS,Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlamaria","family":"Zoja","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCS,Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3470-1721","authenticated-orcid":false,"given":"Luca","family":"Perico","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCS,Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Remuzzi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, Istituto di Ricerche Farmacologiche Mario Negri IRCCS,Centro Anna Maria Astori, Science and Technology Park Kilometro Rosso, Bergamo, Italy"},{"name":"\u2018L. Sacco\u2019 Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"key":"CIT0001","first-page":"913","volume-title":"Comprehensive Clinical Nephrology","author":"Benigni A","year":"2019","edition":"6"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199811123392007"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.semnephrol.2003.11.005"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.03.025"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2012040390"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1159\/000445844"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-6386(86)80051-8"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00342.x"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00057.2012"},{"issue":"3","key":"CIT0010","first-page":"481","volume":"122","author":"Diamond JR","year":"1986","journal-title":"Am J Pathol"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.060003957.x"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1053\/snep.2003.50015"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1053\/snep.2003.50017"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000060"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00149.x"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1097\/01.mnh.0000222688.69217.8e"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007060686"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2001.059002601.x"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.10072"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2006.050398"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014080752"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.01.012"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000322"},{"issue":"11","key":"CIT0024","doi-asserted-by":"crossref","first-page":"2440","DOI":"10.1681\/ASN.V10112440","volume":"10","author":"Tryggvason K","year":"1999","journal-title":"J Am Soc Nephrol"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.05.015"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e3283522e7a"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000221"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021115-105412"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.152"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2015.07.003"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.256"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000311"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013050452"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013050481"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2014.1"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.04.003"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1038\/srep28445"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.08.008"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.127"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017020143"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3843"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1111\/tra.12178"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfw463"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1172\/JCI58552"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1002\/path.5181"},{"issue":"4","key":"CIT0046","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/path.5217","volume":"247","author":"Altintas MM","year":"2019","journal-title":"J Pathol"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1038\/nm1696"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14004"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4242"},{"key":"CIT0050","volume":"130","author":"Wei C","year":"2019","journal-title":"J Clin Invest"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1172\/JCI127927"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2411"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1506362"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4362"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1126\/science.360.6386.254"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1159\/000490118"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013040425"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3008538"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4287"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1820414116"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00298.2010"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1126\/science.1106215"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015030318"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006091010"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-015-3224-1"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2010111146"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016111248"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69778"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2018.4"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.04.001"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2001200"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71165"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal4178"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017060682"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00550.2016"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1172\/JCI69557"},{"issue":"3","key":"CIT0077","first-page":"1593","volume":"42","author":"Han SS","year":"2018","journal-title":"Int J Mol Med"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.345983"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018030324"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1038\/nm1731"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-016-1247-y"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.11.014"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1002\/stem.492"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4296"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2013090968"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1100831"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2017111218"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2014.00211"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014030289"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-007-0440-4"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.12.008"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1159\/000444370"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1172\/JCI77632"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00937-2"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014121271"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00521.2014"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.17165"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101214"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00498-4"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfv355"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.09.002"},{"key":"CIT0102","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.98720"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000343"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2017.03.006"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13228"},{"issue":"1","key":"CIT0106","doi-asserted-by":"crossref","first-page":"e0144640","DOI":"10.1371\/journal.pone.0144640","volume":"11","author":"Zhang Y","year":"2016","journal-title":"PLoS One"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00445.2017"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71195"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2009020132"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000102468.37809.C6"},{"key":"CIT0111","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006101115"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.04.009"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2017.07.004"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1021\/jm801065q"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2018.08.013"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3691"},{"key":"CIT0117","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2013.197"},{"key":"CIT0118","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000079"},{"key":"CIT0119","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008080879"},{"key":"CIT0120","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.98214"},{"key":"CIT0121","doi-asserted-by":"publisher","DOI":"10.2337\/dbi18-0007"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14807"}],"container-title":["Expert Opinion on Therapeutic Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14728222.2019.1626827","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T03:24:24Z","timestamp":1694921064000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14728222.2019.1626827"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,12]]},"references-count":122,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,5,22]]},"published-print":{"date-parts":[[2019,7,3]]}},"alternative-id":["10.1080\/14728222.2019.1626827"],"URL":"https:\/\/doi.org\/10.1080\/14728222.2019.1626827","relation":{},"ISSN":["1472-8222","1744-7631"],"issn-type":[{"value":"1472-8222","type":"print"},{"value":"1744-7631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,12]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iett20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iett20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}