{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:37:45Z","timestamp":1789677465490,"version":"4.0.1"},"reference-count":252,"publisher":"Informa UK Limited","issue":"10","funder":[{"name":"Rachadapisek Sompote Fund for Postdoctoral Fellowship, Chulalongkorn University"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Targets"],"published-print":{"date-parts":[[2020,10,2]]},"DOI":"10.1080\/14728222.2020.1805435","type":"journal-article","created":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T03:47:59Z","timestamp":1596512879000},"page":"1009-1028","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":47,"title":["Using sigma-ligands as part of a multi-receptor approach to target diseases of the brain"],"prefix":"10.1080","volume":"24","author":[{"given":"James Michael","family":"Brimson","sequence":"first","affiliation":[{"name":"Age-related Inflammation and Degeneration Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirikalaya","family":"Brimson","sequence":"additional","affiliation":[{"name":"Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanichon","family":"Chomchoei","sequence":"additional","affiliation":[{"name":"Department of Clinical Microscopy, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tewin","family":"Tencomnao","sequence":"additional","affiliation":[{"name":"Age-related Inflammation and Degeneration Research Unit, Department of Clinical Chemistry, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2020,8,31]]},"reference":[{"issue":"3","key":"cit0001","first-page":"517","volume":"197","author":"Martin WR","year":"1976","journal-title":"J Pharmacol Exp Ther"},{"issue":"2","key":"cit0002","first-page":"284","volume":"223","author":"Su T-P.","year":"1982","journal-title":"J Pharmacol Exp Ther"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(83)90297-2"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(83)91193-9"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.83.18.7104"},{"issue":"2","key":"cit0006","first-page":"543","volume":"259","author":"Su T-P","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(90)91143-5"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(92)90030-A"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.15.8072"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.1842"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7840"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1038\/nature17391"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky427"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09654-8"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20141321"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.119.262790"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.537993"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061245"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00017"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1038\/s41594-018-0137-2"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.CRJ04005X"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-01-00117.1995"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.05.009"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1771"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.103.051292"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.08.036"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00677-3"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2010.08.007"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01417.x"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145714000029"},{"issue":"2","key":"cit0031","first-page":"408","volume":"55","author":"Vilner BJ","year":"1995","journal-title":"Cancer Res"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705154114"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(89)81427-9"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1002\/0471141755.ph0134s71"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00309"},{"issue":"13","key":"cit0036","first-page":"3474","volume":"49","author":"Sonnenschein C","year":"1989","journal-title":"Cancer Res"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.5919"},{"issue":"7","key":"cit0038","first-page":"515","volume":"1","author":"Wetherill YB","year":"2002","journal-title":"Mol Cancer Ther"},{"issue":"3","key":"cit0039","first-page":"788","volume":"293","author":"Hayashi T","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-018-9883-5"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-200508010-00018"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awu107"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91397-8"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-5846(96)00160-1"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(01)00112-6"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1016\/S0924-977X(99)80011-X"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30391-0"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.2.491"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1038\/351751a0"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-6446(04)03163-0"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1586\/14779072.2.5.675"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.2165\/00151829-200403050-00002"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1038\/nrd1346"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199103143241107"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1021\/jm070559a"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7091-6301-6_10"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01801.x"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(96)00104-9"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(95)00241-A"},{"issue":"2","key":"cit0060","first-page":"438","volume":"295","author":"Buccafusco JJ","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00862"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0458-14.2014"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2012.09.007"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.01.030"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002558"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2008.06.011"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.041970"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0209250"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.FP0070563"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.01.064"},{"key":"cit0071","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq367"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2010.1674"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.15-07-04970.1995"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2125.1999.00026.x"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c67808"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1304839"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1312889"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.06-06-01757.1986"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1007\/BF02985120"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00152-5"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-007-0094-z"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410420114"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2014.00463"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706927"},{"issue":"3","key":"cit0085","first-page":"303","volume":"3","author":"Cacabelos R","year":"2007","journal-title":"Neuropsychiatr Dis Treat"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2015.09.020"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2014.12.005"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(00)00148-6"},{"key":"cit0089","doi-asserted-by":"publisher","DOI":"10.1021\/jm00034a020"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00519"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.08.038"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.1126\/science.aao2300"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X13666151009120153"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2012.01.022"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/947149"},{"key":"cit0096","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2013.08.037"},{"key":"cit0097","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00141.x"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20281"},{"key":"cit0099","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2011.00003"},{"key":"cit0100","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2011.03.091"},{"key":"cit0101","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1868"},{"key":"cit0102","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.04.272"},{"key":"cit0103","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-015-3997-8"},{"key":"cit0104","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27565"},{"key":"cit0105","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.12.022"},{"key":"cit0106","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01012"},{"key":"cit0107","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.70"},{"key":"cit0108","doi-asserted-by":"publisher","DOI":"10.3390\/cells8030211"},{"key":"cit0109","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.11.009"},{"key":"cit0110","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-111643"},{"key":"cit0111","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2396(20000315)35:4<311::AID-SYN9>3.0.CO;2-5"},{"key":"cit0112","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2004.10.002"},{"key":"cit0113","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(01)01205-X"},{"key":"cit0114","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.3.430"},{"key":"cit0115","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00909-3"},{"key":"cit0116","doi-asserted-by":"publisher","DOI":"10.1002\/syn.890040311"},{"key":"cit0117","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050205"},{"key":"cit0118","doi-asserted-by":"publisher","DOI":"10.1023\/A:1027361101419"},{"key":"cit0119","doi-asserted-by":"publisher","DOI":"10.1007\/BF01271226"},{"key":"cit0120","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(95)00618-Z"},{"key":"cit0121","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00283-7"},{"key":"cit0122","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)83020-8"},{"key":"cit0123","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(94)00378-5"},{"key":"cit0124","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.9.3774"},{"key":"cit0125","doi-asserted-by":"publisher","DOI":"10.1126\/science.1166127"},{"key":"cit0126","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.12.051"},{"key":"cit0127","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.82.8.4161"},{"issue":"4","key":"cit0128","first-page":"316","volume":"131","author":"Nafziger AN","year":"1998","journal-title":"Transl Res"},{"key":"cit0129","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-59-3-551"},{"issue":"3","key":"cit0130","first-page":"1173","volume":"81","author":"Ravaglia G","year":"1996","journal-title":"J Clin Endocrinol Metab"},{"key":"cit0131","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1995.03530110064037"},{"key":"cit0132","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2015.10214"},{"key":"cit0133","unstructured":"Avanir. Avanir pharmaceuticals announces initiation of Phase III trial of AVP-786 for agitation in patients with Alzheimer\u2019s disease. 2015."},{"key":"cit0134","doi-asserted-by":"publisher","DOI":"10.1111\/j.0953-816X.2004.03297.x"},{"key":"cit0135","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2005.00432.x"},{"key":"cit0136","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.08.007"},{"key":"cit0137","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.190868"},{"key":"cit0138","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-00699-9"},{"key":"cit0139","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22534"},{"key":"cit0140","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201606403"},{"issue":"1","key":"cit0141","first-page":"2","volume":"37","author":"Almendra L","year":"2018","journal-title":"Acta Myologica"},{"key":"cit0142","unstructured":"FUS S Compound heterozygote mutations in the SIGMAR1 gene in an oldest-old patient with amyotrophic lateral sclerosis. 2018."},{"key":"cit0143","doi-asserted-by":"publisher","DOI":"10.1124\/mol.116.104018"},{"key":"cit0144","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2017.88"},{"key":"cit0145","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt008"},{"key":"cit0146","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2013.02.035"},{"key":"cit0147","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.02.022"},{"key":"cit0148","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.116178"},{"key":"cit0149","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.603506"},{"key":"cit0150","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphs.2014.12.013"},{"key":"cit0151","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.10.010"},{"key":"cit0152","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1451-2"},{"key":"cit0153","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037989"},{"key":"cit0154","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.03.067"},{"key":"cit0155","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.04.010"},{"key":"cit0156","doi-asserted-by":"publisher","DOI":"10.1021\/jm501981g"},{"key":"cit0157","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-016-0508-5"},{"key":"cit0158","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072232"},{"key":"cit0159","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-315622"},{"key":"cit0160","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22093"},{"key":"cit0161","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(88)90024-3"},{"key":"cit0162","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(89)90050-3"},{"key":"cit0163","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(89)90510-9"},{"key":"cit0164","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)08220-X"},{"key":"cit0165","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020353"},{"key":"cit0166","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0402890101"},{"key":"cit0167","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.52.2.346"},{"key":"cit0168","doi-asserted-by":"publisher","DOI":"10.1002\/glia.22639"},{"key":"cit0169","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13037"},{"key":"cit0170","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2004.06.029"},{"key":"cit0171","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2528"},{"key":"cit0172","doi-asserted-by":"publisher","DOI":"10.1172\/JCI45691"},{"key":"cit0173","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.11.005"},{"key":"cit0174","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.170"},{"key":"cit0175","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.10.006"},{"key":"cit0176","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.95665"},{"key":"cit0177","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00037"},{"key":"cit0178","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0259-3"},{"key":"cit0179","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1637-10.2010"},{"key":"cit0180","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.05.055"},{"key":"cit0181","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M508157200"},{"key":"cit0182","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21549"},{"key":"cit0183","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddw238"},{"key":"cit0184","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25362"},{"key":"cit0185","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70233-2"},{"key":"cit0186","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-190393"},{"key":"cit0187","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(02)00653-0"},{"key":"cit0188","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852900022641"},{"key":"cit0189","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.153.2.151"},{"issue":"4","key":"cit0190","first-page":"512","volume":"36","author":"Itzhak Y","year":"1989","journal-title":"Mol Pharmacol"},{"key":"cit0191","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00254-3"},{"key":"cit0192","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90100-V"},{"key":"cit0193","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2003.12.018"},{"key":"cit0194","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(96)00497-9"},{"issue":"3","key":"cit0195","first-page":"1269","volume":"298","author":"Urani A","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"cit0196","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(98)00093-8"},{"key":"cit0197","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2008.11.036"},{"key":"cit0198","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)90139-W"},{"key":"cit0199","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.05.043"},{"key":"cit0200","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2007.02.007"},{"key":"cit0201","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-65849-6"},{"key":"cit0202","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704294"},{"key":"cit0203","doi-asserted-by":"publisher","DOI":"10.1111\/j.2042-7158.1990.tb06588.x"},{"key":"cit0204","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-832677"},{"key":"cit0205","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-832680"},{"key":"cit0206","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1150-y"},{"key":"cit0207","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2007.04.055"},{"issue":"1","key":"cit0208","first-page":"19","volume":"64","author":"Schatzberg AF","year":"2003","journal-title":"J Clin Psychiatry"},{"key":"cit0209","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.153.3.414"},{"key":"cit0210","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v60n0511"},{"key":"cit0211","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199812000-00004"},{"key":"cit0212","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.153.12.1631"},{"key":"cit0213","doi-asserted-by":"publisher","DOI":"10.1002\/hup.1106"},{"key":"cit0214","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2007.05639.x"},{"key":"cit0215","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-005-1038-0"},{"key":"cit0216","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2003.12.004"},{"key":"cit0217","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000218445.30535.6f"},{"key":"cit0218","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145705005213"},{"key":"cit0219","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300982"},{"key":"cit0220","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2005.03968.x"},{"key":"cit0221","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2004.07.008"},{"key":"cit0222","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300234"},{"key":"cit0223","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909089106"},{"key":"cit0224","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145705005766"},{"key":"cit0225","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300514"},{"key":"cit0226","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.72.121801.161629"},{"key":"cit0227","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr255"},{"key":"cit0228","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.v06n0403"},{"key":"cit0229","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2008.00605.x"},{"key":"cit0230","volume-title":"ASCP Annual Meeting","author":"Anderson A","year":"2019"},{"key":"cit0231","doi-asserted-by":"crossref","unstructured":"Matsumoto RR. \u03c3 Receptors: historical perspective and background. Boston, MA: Springer; 2007. p. 1\u201323.","DOI":"10.1007\/978-0-387-36514-5_1"},{"key":"cit0232","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.04.005"},{"key":"cit0233","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-3803"},{"key":"cit0234","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1386"},{"issue":"3","key":"cit0235","first-page":"900","volume":"292","author":"Vilner BJ","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"cit0236","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.26.18387"},{"key":"cit0237","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90158-9"},{"key":"cit0238","doi-asserted-by":"publisher","DOI":"10.1016\/0922-4106(94)90115-5"},{"key":"cit0239","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2013.744746"},{"key":"cit0240","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2013.12.008"},{"key":"cit0241","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00383.2010"},{"key":"cit0242","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35430-3"},{"key":"cit0243","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111899"},{"key":"cit0244","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13917"},{"key":"cit0245","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1519024"},{"issue":"3","key":"cit0246","first-page":"1323","volume":"283","author":"Sanchez C","year":"1997","journal-title":"J Pharmacol Exp Ther"},{"key":"cit0247","doi-asserted-by":"publisher","DOI":"10.1097\/00008877-200004000-00003"},{"key":"cit0248","first-page":"S71","volume":"22","author":"Zerkak D","year":"2004","journal-title":"Clin Exp Rheumatol"},{"key":"cit0249","first-page":"917","volume":"45","author":"Steele LS","year":"1999","journal-title":"Can Family Physician"},{"key":"cit0250","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15048"},{"key":"cit0251","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107541"},{"key":"cit0252","first-page":"1","author":"Hudd F","year":"2019","journal-title":"J Alzheimers Dis"}],"container-title":["Expert Opinion on Therapeutic Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14728222.2020.1805435","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,3,30]],"date-time":"2021-03-30T11:37:29Z","timestamp":1617104249000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14728222.2020.1805435"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,31]]},"references-count":252,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10,2]]}},"alternative-id":["10.1080\/14728222.2020.1805435"],"URL":"https:\/\/doi.org\/10.1080\/14728222.2020.1805435","relation":{},"ISSN":["1472-8222","1744-7631"],"issn-type":[{"value":"1472-8222","type":"print"},{"value":"1744-7631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,31]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iett20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iett20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-01-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}