{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T10:16:24Z","timestamp":1772705784229,"version":"3.50.1"},"reference-count":134,"publisher":"Informa UK Limited","issue":"2","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82370457"],"award-info":[{"award-number":["82370457"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Targets"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1080\/14728222.2026.2625100","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T05:59:42Z","timestamp":1769666382000},"page":"147-162","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Bidirectional nexus between metabolic disease and aortic valve calcification: from pathogenic mechanisms to integrated multimorbidity management"],"prefix":"10.1080","volume":"30","author":[{"given":"Xinyue","family":"Wang","sequence":"first","affiliation":[{"name":"Affiliated Hospital of Jiangsu University","place":["Zhenjiang, China"]},{"name":"Jiangsu University","place":["Zhenjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mincheng","family":"Yu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangsu University","place":["Zhenjiang, China"]},{"name":"Jiangsu University","place":["Zhenjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingzheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangsu University","place":["Zhenjiang, China"]},{"name":"Jiangsu University","place":["Zhenjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Xu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangsu University","place":["Zhenjiang, China"]},{"name":"Jiangsu University","place":["Zhenjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Liu","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangsu University","place":["Zhenjiang, China"]},{"name":"Jiangsu University","place":["Zhenjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongqun","family":"Wang","sequence":"additional","affiliation":[{"name":"Affiliated Hospital of Jiangsu University","place":["Zhenjiang, China"]},{"name":"Jiangsu University","place":["Zhenjiang, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2026,2,3]]},"reference":[{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.124.037991"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.6"},{"key":"e_1_3_6_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adg0478"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/cir.0000000000000932"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2023.02.018"},{"key":"e_1_3_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.110.234146"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.90.2.844"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21218263"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/med.0000000000000471"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carpath.2024.107667"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00015385.2020.1746053"},{"key":"e_1_3_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.119.313067"},{"key":"e_1_3_6_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23073776"},{"key":"e_1_3_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.122.318334"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.01.005"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2019.06.006"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117143"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2024.07.036"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-33202-2"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2023.06.004"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14121547"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab273"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-024-00882-z"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00604"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx653"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.117.309021"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.937886"},{"key":"e_1_3_6_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2024.01.009"},{"key":"e_1_3_6_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.123.029542"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1577762"},{"key":"e_1_3_6_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.atv.0000255952.47980.c2"},{"key":"e_1_3_6_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02634-7"},{"key":"e_1_3_6_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.116.308999"},{"key":"e_1_3_6_36_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-0294"},{"key":"e_1_3_6_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft310"},{"key":"e_1_3_6_38_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.122.317332"},{"key":"e_1_3_6_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2010.44"},{"key":"e_1_3_6_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(87)91370-5"},{"key":"e_1_3_6_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-022-02758-y"},{"key":"e_1_3_6_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa070"},{"key":"e_1_3_6_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241713622"},{"key":"e_1_3_6_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/mol.0000000000000856"},{"key":"e_1_3_6_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12335"},{"key":"e_1_3_6_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2022.06.003"},{"key":"e_1_3_6_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwaf157"},{"key":"e_1_3_6_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-025-02906-2"},{"key":"e_1_3_6_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2021.11.029"},{"key":"e_1_3_6_50_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.122.318004"},{"key":"e_1_3_6_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2023.01.007"},{"key":"e_1_3_6_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-21517-1"},{"key":"e_1_3_6_53_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwaf106"},{"key":"e_1_3_6_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.70285"},{"key":"e_1_3_6_55_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.rcm2508276"},{"key":"e_1_3_6_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14070888"},{"key":"e_1_3_6_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.173"},{"key":"e_1_3_6_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16937"},{"key":"e_1_3_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104861"},{"key":"e_1_3_6_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-021-05545-w"},{"key":"e_1_3_6_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01068-7"},{"key":"e_1_3_6_62_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052713"},{"key":"e_1_3_6_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.12.012"},{"key":"e_1_3_6_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym12122786"},{"key":"e_1_3_6_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab142"},{"key":"e_1_3_6_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.119.313248"},{"key":"e_1_3_6_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-011-9384-7"},{"key":"e_1_3_6_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvae101"},{"key":"e_1_3_6_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-04981-x"},{"key":"e_1_3_6_70_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.10909"},{"key":"e_1_3_6_71_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.92447"},{"key":"e_1_3_6_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115530"},{"key":"e_1_3_6_73_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13018"},{"key":"e_1_3_6_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.31464"},{"key":"e_1_3_6_75_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvab107"},{"key":"e_1_3_6_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfae421"},{"key":"e_1_3_6_77_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2351532"},{"key":"e_1_3_6_78_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22126270"},{"key":"e_1_3_6_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaf106"},{"key":"e_1_3_6_80_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13060481"},{"key":"e_1_3_6_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2023.03.011"},{"key":"e_1_3_6_82_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202000888r"},{"key":"e_1_3_6_83_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq237"},{"key":"e_1_3_6_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.05.066"},{"key":"e_1_3_6_85_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.120.315261"},{"key":"e_1_3_6_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-023-00845-7"},{"key":"e_1_3_6_87_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaf216"},{"key":"e_1_3_6_88_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.110.966846"},{"key":"e_1_3_6_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2019.10.004"},{"key":"e_1_3_6_90_1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.115.016757"},{"key":"e_1_3_6_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvx089"},{"key":"e_1_3_6_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12040227"},{"key":"e_1_3_6_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114161"},{"key":"e_1_3_6_94_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.110.211029"},{"key":"e_1_3_6_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-023-04171-x"},{"key":"e_1_3_6_96_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2012-1216"},{"key":"e_1_3_6_97_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-017-1190-z"},{"key":"e_1_3_6_98_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvac175"},{"key":"e_1_3_6_99_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0823"},{"key":"e_1_3_6_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2261-13-13"},{"key":"e_1_3_6_101_1","doi-asserted-by":"publisher","DOI":"10.5551\/jat.7120"},{"issue":"10","key":"e_1_3_6_102_1","first-page":"12260","article-title":"Advanced glycation endproducts regulate smooth muscle cells calcification in cultured HSMCs","volume":"8","author":"He HQ","year":"2015","unstructured":"He HQ, Liu Y, Zeng H, et al. Advanced glycation endproducts regulate smooth muscle cells calcification in cultured HSMCs. Int J Clin Exp Pathol. 2015;8(10):12260\u201312267. Available from: https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC4680356\/","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_3_6_103_1","doi-asserted-by":"publisher","DOI":"10.1159\/000369126"},{"key":"e_1_3_6_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2019.10.001"},{"key":"e_1_3_6_105_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15787"},{"key":"e_1_3_6_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2024.10.025"},{"key":"e_1_3_6_107_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe3706"},{"key":"e_1_3_6_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.04.001"},{"key":"e_1_3_6_109_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.r113.460261"},{"key":"e_1_3_6_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154799"},{"key":"e_1_3_6_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2025.119146"},{"key":"e_1_3_6_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/s2666-7568(22)00079-4"},{"key":"e_1_3_6_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c220019"},{"key":"e_1_3_6_114_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065241"},{"key":"e_1_3_6_115_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.113.301036"},{"key":"e_1_3_6_116_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.124.322375"},{"key":"e_1_3_6_117_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.cj-24-0706"},{"key":"e_1_3_6_118_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-02025-w"},{"key":"e_1_3_6_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvad077"},{"key":"e_1_3_6_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.107430"},{"key":"e_1_3_6_121_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.122.320888"},{"key":"e_1_3_6_122_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-02025-7"},{"key":"e_1_3_6_123_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202307319"},{"key":"e_1_3_6_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2024.06.037"},{"key":"e_1_3_6_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11123331"},{"key":"e_1_3_6_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2023.02.013"},{"key":"e_1_3_6_127_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2024.1882"},{"key":"e_1_3_6_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(13)60897-1"},{"key":"e_1_3_6_129_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.709741"},{"key":"e_1_3_6_130_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm592"},{"key":"e_1_3_6_131_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216471"},{"key":"e_1_3_6_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44726-0"},{"key":"e_1_3_6_133_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0822"},{"key":"e_1_3_6_134_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.125.322959"},{"key":"e_1_3_6_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.08.020"},{"key":"e_1_3_6_136_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.124.325976"}],"container-title":["Expert Opinion on Therapeutic Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14728222.2026.2625100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T09:25:37Z","timestamp":1772702737000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14728222.2026.2625100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":134,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1080\/14728222.2026.2625100"],"URL":"https:\/\/doi.org\/10.1080\/14728222.2026.2625100","relation":{},"ISSN":["1472-8222","1744-7631"],"issn-type":[{"value":"1472-8222","type":"print"},{"value":"1744-7631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iett20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iett20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-11-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}