{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:44:02Z","timestamp":1792673042895,"version":"4.5.0"},"reference-count":98,"publisher":"Informa UK Limited","license":[{"start":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T00:00:00Z","timestamp":1792627200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Therapeutic Targets"],"DOI":"10.1080\/14728222.2026.2748747","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:59:31Z","timestamp":1792155571000},"page":"1-16","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Targeting the microbiota-gut-brain axis in Alzheimer\u2019s and Parkinson\u00b4s disease: recent therapeutic approaches"],"prefix":"10.1080","author":[{"given":"Manuela","family":"Gries","sequence":"first","affiliation":[{"name":"University of Applied Sciences Kaiserslautern","place":["Zweibr\u00fccken, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl-Herbert","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"University of Applied Sciences Kaiserslautern","place":["Zweibr\u00fccken, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Endres","sequence":"additional","affiliation":[{"name":"University of Applied Sciences Kaiserslautern","place":["Zweibr\u00fccken, Germany"]},{"name":"University Medical Center of the Johannes Gutenberg University Mainz","place":["Mainz, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,10,22]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2024.1071"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2024-095610"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13668-024-00539-7"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x14666151208112754"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCMA.0000000000001252"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00439-2"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30356-4"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-025-00307-1"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00049"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S384949"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmz127"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8456596"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.796288"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2018.02.022"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2025.1600148"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70417"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.00025"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2021.757673"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082189"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2023.0309"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom16010156"},{"key":"e_1_3_4_24_1","unstructured":"De M Fonseca C Zanetti L et al. Personal view the gut microbiome systemic inflammation and autoimmunity in Parkinson\u2019s disease [Internet]. 2026. Available from: www.thelancet.com\/neurology"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2016.08.019"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01578-6"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1647967"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2026.2614030"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-025-00953-9"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2025.1593854"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms9122548"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00178-25"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-05267-9"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2025.117708"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/foods15030429"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/medicina62010091"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2025.109904"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.145427"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251345157"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-024-11028-y"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1006\/anae.2001.0376"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-025-04960-z"},{"key":"e_1_3_4_43_1","unstructured":"Vemuganti V Kang JW Zhang Q et al. Gut bacterial metabolite imidazole propionate potentiates Alzheimer\u2019s disease pathology [Internet]. 2025. Available from: http:\/\/biorxiv.org\/lookup\/doi\/10.1101\/2025.06.08.657719"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2025.152290"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-026-68937-9"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/01616412.2025.2520019"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu17203313"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00662"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00744-25"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.34136"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-025-10270-x"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1006\/anae.2001.0376"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-024-02133-z"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2025.152418"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-07209-4"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13122659"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15111486"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251389922"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877261415612"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1021\/JACS.5C19753"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.5c00467"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.70235"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25040925"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2024.2305"},{"key":"e_1_3_4_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-025-01061-5"},{"key":"e_1_3_4_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-026-02604-9"},{"key":"e_1_3_4_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2025.1639911"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2026.106257"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1155\/bn\/8401392"},{"key":"e_1_3_4_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-025-00797-5"},{"key":"e_1_3_4_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2025.106093"},{"key":"e_1_3_4_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2025.12.028"},{"key":"e_1_3_4_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-025-07435-w"},{"key":"e_1_3_4_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2026.111011"},{"key":"e_1_3_4_75_1","doi-asserted-by":"publisher","DOI":"10.1111\/nmo.14745"},{"key":"e_1_3_4_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-025-10499-1"},{"key":"e_1_3_4_77_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03379-24"},{"key":"e_1_3_4_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micres.2025.128436"},{"key":"e_1_3_4_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2025.106217"},{"key":"e_1_3_4_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.70047"},{"key":"e_1_3_4_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-025-01022-y"},{"key":"e_1_3_4_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-026-04698-7"},{"key":"e_1_3_4_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2025.04.001"},{"key":"e_1_3_4_84_1","doi-asserted-by":"publisher","DOI":"10.34133\/research.0846"},{"key":"e_1_3_4_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-025-01498-x"},{"key":"e_1_3_4_86_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5c06844"},{"key":"e_1_3_4_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2025.157596"},{"key":"e_1_3_4_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-29692-x"},{"key":"e_1_3_4_89_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-025-02438-0"},{"key":"e_1_3_4_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu18081208"},{"key":"e_1_3_4_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2025.110191"},{"key":"e_1_3_4_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.149946"},{"key":"e_1_3_4_93_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000044780"},{"key":"e_1_3_4_94_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm15010368"},{"key":"e_1_3_4_95_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488629"},{"key":"e_1_3_4_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf413"},{"key":"e_1_3_4_97_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.70608"},{"key":"e_1_3_4_98_1","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/bs.pmbts.2026.01.029","article-title":"Live biotherapeutics in the clinic: regulatory pathways, market dynamics, and future trends","volume":"220","author":"Das B","year":"2026","unstructured":"Das B. Live biotherapeutics in the clinic: regulatory pathways, market dynamics, and future trends. Prog Mol Biol Transl Sci [Internet]. 2026 [cited 2026 Oct 1];220:405\u2013416.","journal-title":"Prog Mol Biol Transl Sci"},{"key":"e_1_3_4_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-026-50859-7"},{"key":"e_1_3_4_100_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70331"}],"container-title":["Expert Opinion on Therapeutic Targets"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14728222.2026.2748747","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/14728222.2026.2748747","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14728222.2026.2748747","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:00:07Z","timestamp":1792670407000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14728222.2026.2748747"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":98,"alternative-id":["10.1080\/14728222.2026.2748747"],"URL":"https:\/\/doi.org\/10.1080\/14728222.2026.2748747","relation":{},"ISSN":["1472-8222","1744-7631"],"issn-type":[{"value":"1472-8222","type":"print"},{"value":"1744-7631","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,22]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iett20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iett20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-06-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}