{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:52:08Z","timestamp":1790545928194,"version":"4.1.0"},"reference-count":82,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2006,6,1]],"date-time":"2006-06-01T00:00:00Z","timestamp":1149120000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebellum"],"published-print":{"date-parts":[[2006,6]]},"DOI":"10.1080\/14734220600697211","type":"journal-article","created":{"date-parts":[[2006,6,10]],"date-time":"2006-06-10T03:03:33Z","timestamp":1149908613000},"page":"89-96","source":"Crossref","is-referenced-by-count":41,"title":["Biosynthesis and organizing action of neurosteroids in the developing Purkinje cell"],"prefix":"10.1007","volume":"5","author":[{"given":"Kazuyoshi","family":"Tsutsui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"5289_CR1","volume-title":"Steroid hormone regulation of the brain","author":"K Fuxe","year":"1981","unstructured":"Fuxe K, Gustafsson JA, Wetterberg L. Steroid hormone regulation of the brain. Oxford: Pergamon Press, 1981."},{"key":"5289_CR2","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1146\/annurev.ne.07.030184.002213","volume":"7","author":"AP Arnold","year":"1984","unstructured":"Arnold AP, Gorski RA. Gonadal steroid induction of structural sex differences in the CNS. Annu Rev Neurosci. 1984;7:413\u201342.","journal-title":"Annu Rev Neurosci"},{"key":"5289_CR3","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/1043-2760(91)90042-L","volume":"2","author":"BS McEwen","year":"1991","unstructured":"McEwen BS. Steroid hormones are multifunctional messengers in the brain. Trends Endocrinol Metab. 1991;2:62\u20137.","journal-title":"Trends Endocrinol Metab"},{"key":"5289_CR4","first-page":"1","volume":"52","author":"EE Baulieu","year":"1997","unstructured":"Baulieu EE. Neurosteroids: of the nervous system, by the nervous system, for the nervous system (review). Rec Progr Hormone Res. 1997;52:1\u201332.","journal-title":"Rec Progr Hormone Res"},{"key":"5289_CR5","first-page":"121","volume":"124","author":"K Tsutsui","year":"1999","unstructured":"Tsutsui K, Ukena K, Takase M, Kohchi C, Lea RW. Neurosteroid biosynthesis in vertebrate brains (review). Comp Biochem Physiol C. 1999;124:121\u20139.","journal-title":"Comp Biochem Physiol C"},{"key":"5289_CR6","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1016\/S0168-0102(99)00132-7","volume":"36","author":"K Tsutsui","year":"2000","unstructured":"Tsutsui K, Ukena K, Usui M, Sakamoto H, Takase M. Novel brain function: biosynthesis and actions of neurosteroids in neurons (review). Neurosci Res. 2000;36:261\u201373.","journal-title":"Neurosci Res"},{"key":"5289_CR7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1006\/frne.1999.0188","volume":"21","author":"NA Compagnone","year":"2000","unstructured":"Compagnone NA, Mellon SH. Neurosteroids: biosynthesis and function of these novel neuromodulators (review). Frontiers Neuroendocrinol. 2000;21:1\u201356.","journal-title":"Frontiers Neuroendocrinol"},{"key":"5289_CR8","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0074-7742(01)46058-2","volume":"46","author":"SH Mellon","year":"2001","unstructured":"Mellon SH, Vaudry H. Biosynthesis of neurosteroids and regulation of their synthesis (review). Int Rev Neurobiol. 2001;46:33\u201378.","journal-title":"Int Rev Neurobiol"},{"key":"5289_CR9","doi-asserted-by":"publisher","first-page":"4704","DOI":"10.1073\/pnas.78.8.4704","volume":"78","author":"C Corp\u2019echot","year":"1981","unstructured":"Corp\u2019echot C, Robel P, Axelson M, Sj\u00f6vall J, Baulieu EE. Characterization and measurement of dehydroepiandrosterone sulfate in rat brain. Proc Natl Acad Sci USA. 1981;78:4704\u201307.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5289_CR10","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/0006-8993(83)90797-7","volume":"270","author":"C Corp\u2019echot","year":"1983","unstructured":"Corp\u2019echot C, Synguelakis M, Talha S, et al. Pregnenolone and its sulfate ester in rat brain. Brain Res. 1983;270:119\u201325.","journal-title":"Brain Res"},{"key":"5289_CR11","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1016\/0197-0186(85)90143-3","volume":"7","author":"P Robel","year":"1985","unstructured":"Robel P, Baulieu EE. Neuro-steroids, 3\u03b2-hydroxy-\u03945 derivatives in the rodent brain. Neurochem Int. 1985;7: 953\u20138.","journal-title":"Neurochem Int"},{"key":"5289_CR12","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/0022-4731(86)90259-1","volume":"25","author":"A Lanthier","year":"1986","unstructured":"Lanthier A, Patwardhan VV. Sex steroids and 5-en-3\u03b2hydroxysteroids in specific regions of the human brain and cranial nerves. J Steroid Biochem. 1986;25:445\u20139.","journal-title":"J Steroid Biochem"},{"key":"5289_CR13","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/978-1-4684-5131-3_31","volume-title":"Neuroendocrine molecular biology","author":"P Robel","year":"1986","unstructured":"Robel P, Corp\u2019echot C, Clarke C, et al. Neuro-steroids:3\u03b2- hydroxy-\u03945-derivatives in the rat brain. In: Fink G, Harmar AJ, McKerns KW, editors. Neuroendocrine molecular biology. New York: Plenum Press, 1986:367\u201377."},{"key":"5289_CR14","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/0022-4731(87)90133-6","volume":"27","author":"P Robel","year":"1987","unstructured":"Robel P, Bourreau E, Corp\u2019echot C, et al. Neuro-steroids:3\u03b2- hydroxy-\u03945-derivatives in rat and monkey brain. J Steroid Biochem. 1987;27:649\u201355.","journal-title":"J Steroid Biochem"},{"key":"5289_CR15","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/0039-128X(89)90003-2","volume":"54","author":"DH Jo","year":"1989","unstructured":"Jo DH, Abdallah MA, Young J, Baulieu EE, Robel P. Pregnenolone, dehydroepiandrosterone, and their sulfate and fatty acid esters in the rat brain. Steroids. 1989;54:287\u201397.","journal-title":"Steroids"},{"key":"5289_CR16","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1073\/pnas.90.1.85","volume":"90","author":"C Mathur","year":"1993","unstructured":"Mathur C, Prasad VVK, Raju VS, Welch M, Lieberman S. Steroids and their conjugates in the mammalian brain. Proc Natl Acad Sci USA. 1993;90:85\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5289_CR17","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1016\/0006-8993(93)91332-M","volume":"629","author":"SH Mellon","year":"1993","unstructured":"Mellon SH, Deschepper CF. Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain. Brain Res. 1993;629:283\u201392.","journal-title":"Brain Res"},{"key":"5289_CR18","doi-asserted-by":"publisher","first-page":"5212","DOI":"10.1210\/en.136.11.5212","volume":"136","author":"NA Compagnone","year":"1995","unstructured":"Compagnone NA, Bulfone A, Rubenstein JLR, Mellon SH. Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system. Endocrinology. 1995;136:5212\u201323.","journal-title":"Endocrinology"},{"key":"5289_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0006-8993(95)00116-8","volume":"678","author":"K Tsutsui","year":"1995","unstructured":"Tsutsui K, Yamazaki T. Avianneurosteroids. I. Pregnenolone biosynthesis in the quail brain. Brain Res. 1995;678:1\u20139.","journal-title":"Brain Res"},{"key":"5289_CR20","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/0006-8993(95)00117-9","volume":"678","author":"M Usui","year":"1995","unstructured":"Usui M, Yamazaki T, Kominami S, Tsutsui K. Avian neurosteroids. II. Localization of a cytochrome P450scc-like substance in the quail brain. Brain Res. 1995;678:10\u201320.","journal-title":"Brain Res"},{"key":"5289_CR21","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1006\/gcen.1996.0077","volume":"102","author":"A Vanson","year":"1996","unstructured":"Vanson A, Arnold AP, Schlinger BA. 3b-Hydroxysteroid dehydrogenase\/isomerase and aromatase activity in primary cultures of developing zebra finch telencephalon: dehydroepiandrosterone as substrate for synthesis of androstenedione and estrogens. Gen Comp Endocrinol. 1996;102:342\u201350.","journal-title":"Gen Comp Endocrinol"},{"key":"5289_CR22","first-page":"427","volume-title":"Perspectives in avian endocrinology","author":"K Tsutsui","year":"1997","unstructured":"Tsutsui K, Yamazaki T, Usui M, et al. P450scc activity in the brain. In: Harvey S, Etches RJ, editors. Perspectives in avian endocrinology. Bristol: Journal of Endocrinol Ltd, 1997: 427\u201336."},{"key":"5289_CR23","first-page":"151","volume-title":"Frontiers in environmental and metabolic endocrinology","author":"K Tsutsui","year":"1997","unstructured":"Tsutsui K, Usui M, Yamazaki T, Ukena K, Kominami S. Neurosteroids in the avian brain. In: Maitra SK, editor. Frontiers in environmental and metabolic endocrinology. Burdwan: Burdwan Press; 1997. pp 151\u20139."},{"key":"5289_CR24","doi-asserted-by":"publisher","first-page":"536","DOI":"10.1016\/S0006-8993(98)01296-7","volume":"818","author":"K Ukena","year":"1999","unstructured":"Ukena K, Honda Y, Inai Y, Kohchi C, Lea RW, Tsutsui K. Expression and activity of 3\u03b2-hydroxysteroid dehydrogenase\/ \u03945-\u03944-isomerase in different regions of the avian brain. Brain Res. 1999;818:536\u201342.","journal-title":"Brain Res"},{"key":"5289_CR25","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1006\/gcen.1998.7179","volume":"113","author":"BA Schlinger","year":"1999","unstructured":"Schlinger BA, Lane NI, Grisham W, Thompson L. Androgen synthesis in a songbird: a study of cyp17 (17a-hydroxylase\/ c17,20-lyase) activity in the zebra finch. Gen Comp Endocrinol. 1999;113:46\u201358.","journal-title":"Gen Comp Endocrinol"},{"key":"5289_CR26","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1006\/gcen.2000.7503","volume":"119","author":"F Freking","year":"2000","unstructured":"Freking F, Nazairians T, Schlinger BA. The expression of the sex steroid-synthesizing enzymes CYP11A1, 3\u03b2-HSD, CYP17, and CYP19 in gonads and adrenals of adult and developing zebra finches. Gen Comp Endocrinol. 2000;119: 140\u201351.","journal-title":"Gen Comp Endocrinol"},{"key":"5289_CR27","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/S0006-8993(01)02162-X","volume":"898","author":"K Ukena","year":"2001","unstructured":"Ukena K, Honda Y, Lea RW, Tsutsui K. Developmental changes in progesterone biosynthesis and metabolism in the quail brain. Brain Res. 2001;898:190\u20134.","journal-title":"Brain Res"},{"key":"5289_CR28","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/S0006-8993(01)02217-X","volume":"899","author":"M Matsunaga","year":"2001","unstructured":"Matsunaga M, Ukena K, Tsutsui K. Expression and localization of cytochrome P450 17\u03b1-hydroxylase\/c17, 20-lyase in the avian brain. Brain Res. 2001;899:112\u201322.","journal-title":"Brain Res"},{"key":"5289_CR29","first-page":"59","volume-title":"Avian endocrinology","author":"K Tsutsui","year":"2001","unstructured":"Tsutsui K, Schlinger BA. Steroidogenesis in the avian brain. In: Dawson A, Chaturvedi CM, editors. Avian endocrinology. New Delhi: Narosa Publishing House; 2001. pp 59\u201377."},{"key":"5289_CR30","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1016\/S0006-8993(02)03147-5","volume":"948","author":"M Matsunaga","year":"2002","unstructured":"Matsunaga M, Ukena K, Tsutsui K. Androgen biosynthesis in the quail brain. Brain Res. 2002;948:180\u20135.","journal-title":"Brain Res"},{"key":"5289_CR31","doi-asserted-by":"publisher","first-page":"1668","DOI":"10.1210\/en.2003-0883","volume":"145","author":"KK Soma","year":"2003","unstructured":"Soma KK, Alday NA, Hau M, Schlinger BA. DHEA metabolism by 3b-HSD in adult zebra finch brain: sex difference and rapid effect of stress. Endocrinology. 2003;145:1668\u201377.","journal-title":"Endocrinology"},{"key":"5289_CR32","doi-asserted-by":"publisher","first-page":"63","DOI":"10.3184\/147020603783641297","volume":"14","author":"K Tsutsui","year":"2003","unstructured":"Tsutsui K, Matsunaga M, Ukena K. Biosynthesis and biological actions of neurosteroids in the avian brain (review). Avian Poultry Biol Rev. 2003;14:63\u201378.","journal-title":"Avian Poultry Biol Rev"},{"key":"5289_CR33","doi-asserted-by":"crossref","first-page":"7306","DOI":"10.1523\/JNEUROSCI.14-12-07306.1994","volume":"14","author":"AG Mensah-Nyagan","year":"1994","unstructured":"Mensah-Nyagan AG, Feuilloley M, Dupont E, et al. Immunocytochemical localization and biological activity of 3\u03b2-hydroxysteroid dehydrogenase in the central nervous system of the frog. J Neurosci. 1994;14:7306\u201318.","journal-title":"J Neurosci"},{"key":"5289_CR34","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1073\/pnas.93.4.1423","volume":"93","author":"AG Mensah-Nyagan","year":"1996","unstructured":"Mensah-Nyagan AG, Feuilloley M, Do-Rego JL, et al. Localization of 17\u03b2-hydroxysteroid dehydrogenase and characterization of testosterone in the brain of the male frog. Proc Natl Acad Sci USA. 1996;93:1423\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5289_CR35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1046\/j.1471-4159.1996.67010413.x","volume":"67","author":"AG Mensah-Nyagan","year":"1996","unstructured":"Mensah-Nyagan AG, Do-Rego JL, Feuilloley M, et al. In vivo and in vitro evidence for the biosynthesis of testosterone in the telencephalon of the female frog. J Neurochem. 1996;67:413\u201322.","journal-title":"J Neurochem"},{"key":"5289_CR36","doi-asserted-by":"publisher","first-page":"1936","DOI":"10.1210\/en.140.4.1936","volume":"140","author":"M Takase","year":"1999","unstructured":"Takase M, Ukena K, Yamazaki T, Kominami S, Tsutsui K. Pregnenolone, pregnenolone sulfate and cytochrome P450 side-chain cleavage enzyme in the amphibian brain and their seasonal changes. Endocrinology. 1999;140:1936\u201344.","journal-title":"Endocrinology"},{"key":"5289_CR37","doi-asserted-by":"publisher","first-page":"214","DOI":"10.1016\/S0006-8993(02)03745-9","volume":"959","author":"Y Inai","year":"2003","unstructured":"Inai Y, Nagai K, Ukena K, Oishi T, Tsutsui K. Seasonal changes in neurosteroids in the urodele brain and environmental factors inducing their changes. Brain Res. 2003;959:214\u201325.","journal-title":"Brain Res"},{"key":"5289_CR38","doi-asserted-by":"publisher","first-page":"17282","DOI":"10.1073\/pnas.0407176101","volume":"101","author":"M Matsunaga","year":"2004","unstructured":"Matsunaga M, Ukena K, Baulieu EE, Tsutsui K. 7\u03b1Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system. Proc Natl Acad Sci USA. 2004; 101: 17282\u20137.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5289_CR39","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0031-6997(24)01395-4","volume":"51","author":"AG Mensah-Nyagan","year":"1999","unstructured":"Mensah-Nyagan AG, Do-Rego JL, Beaujean D, Luu-The V, Pelletier G, Vaudry H. Neurosteroids: expression of steroidogenic enzymes and regulation of steroid biosynthesis in the central nervous system (review). Pharmacol Rev. 1999;51: 63\u201381.","journal-title":"Pharmacol Rev"},{"key":"5289_CR40","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/S0165-0173(01)00110-2","volume":"37","author":"AG Mensah-Nyagan","year":"2001","unstructured":"Mensah-Nyagan AG, Beaujean D, Luu-The V, Pelletier G, Vaudry H. Anatomical and biochemical evidence for the synthesis of unconjugated and sulfated neurosteroids in amphibians (review). Brain Res Rev. 2001;37:13\u201324.","journal-title":"Brain Res Rev"},{"key":"5289_CR41","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1002\/cne.1351","volume":"439","author":"H Sakamoto","year":"2001","unstructured":"Sakamoto H, Ukena K, Tsutsui K. Activity and localization of 3b-hydroxysteroid dehydrogenase\/gD5-\u03944-isomerase in the zebrafish central nervous system. J Comp Neurol. 2001;439:291\u2013305.","journal-title":"J Comp Neurol"},{"key":"5289_CR42","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1210\/en.139.1.137","volume":"139","author":"K Ukena","year":"1998","unstructured":"Ukena K, Usui M, Kohchi C, Tsutsui K. Cytochrome P450 side-chain cleavage enzyme in the cerebellar Purkinje neuron and its neonatal change in rats. Endocrinology. 1998;139:137\u201347.","journal-title":"Endocrinology"},{"key":"5289_CR43","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1210\/en.140.2.805","volume":"140","author":"K Ukena","year":"1999","unstructured":"Ukena K, Kohchi C, Tsutsui K. Expression and activity of 3\u03b2-hydroxysteroid dehydrogenase\/gD5-\u03944-isomerase in the rat Purkinje neuron during neonatal life. Endocrinology. 1999;140:805\u201313.","journal-title":"Endocrinology"},{"key":"5289_CR44","doi-asserted-by":"publisher","first-page":"4466","DOI":"10.1210\/en.2003-0307","volume":"144","author":"H Sakamoto","year":"2003","unstructured":"Sakamoto H, Mezaki Y, Shikimi H, Ukena K, Tsutsui K. Dendritic growth and spine formation in response to estrogen in the developing Purkinje cell. Endocrinology. 2003;144: 4466\u201377.","journal-title":"Endocrinology"},{"key":"5289_CR45","doi-asserted-by":"crossref","first-page":"2231","DOI":"10.1046\/j.1471-4159.1998.71062231.x","volume":"71","author":"A Furukawa","year":"1998","unstructured":"Furukawa A, Miyatake A, Ohnishi T, Ichikawa Y. Steroidogenic acute regulatory protein (StAR) transcripts constitutively expressed in the adult rat central nervous system: Colocalization of StAR, cytochrome P-450scc (CYP XIA1), and 3\u03b2-hydroxysteroid dehydrogenase in the rat brain. J Neurochem. 1998;71:2231\u20138.","journal-title":"J Neurochem"},{"key":"5289_CR46","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1111\/j.1365-2826.2004.01226.x","volume":"16","author":"A Sierra","year":"2004","unstructured":"Sierra A. Neurosteroids: the StAR protein in the brain. J Neuroendocrinol. 2004;16:787\u201393.","journal-title":"J Neuroendocrinol"},{"key":"5289_CR47","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1016\/j.neuroscience.2005.05.060","volume":"138","author":"E Lavaque","year":"2006","unstructured":"Lavaque E, Sierra A, Azcoitia I, Garcia-Segura LM. Steroidogenic acute regulatory protein in the brain. Neuroscience. 2006;138:741\u20137.","journal-title":"Neuroscience"},{"key":"5289_CR48","doi-asserted-by":"publisher","first-page":"311","DOI":"10.1016\/S0960-0760(03)00229-2","volume":"85","author":"K Tsutsui","year":"2003","unstructured":"Tsutsui K, Sakamoto H, Ukena K. Biosynthesis and action of neurosteroids in the cerebellar Purkinje neuron. J Steroid Biochem Mol Biol. 2003;85:311\u201321.","journal-title":"J Steroid Biochem Mol Biol"},{"key":"5289_CR49","doi-asserted-by":"crossref","first-page":"28314","DOI":"10.1016\/S0021-9258(18)46930-X","volume":"269","author":"BJ Clark","year":"1994","unstructured":"Clark BJ, Wells J, King SR, Stocco DM. The purification, cloning, and expression of a novel luteinizing hormoneinduced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR). J Biol Chem. 1994;269:28314\u201322.","journal-title":"J Biol Chem"},{"key":"5289_CR50","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1210\/er.17.3.221","volume":"17","author":"DM Stocco","year":"1996","unstructured":"Stocco DM, Clark BJ. Regulation of the acute production of steroids in steroidogenic cells. Endocr Rev. 1996;17:221\u201344.","journal-title":"Endocr Rev"},{"key":"5289_CR51","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/1043-2760(93)90117-W","volume":"4","author":"JI Mason","year":"1993","unstructured":"Mason JI. The 3\u03b2-hydroxysteroid dehydrogenase gene family of enzymes. Trends Endocrinol Metab. 1993;4:199\u2013203.","journal-title":"Trends Endocrinol Metab"},{"key":"5289_CR52","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/S0006-8993(98)00585-X","volume":"801","author":"C Kohchi","year":"1998","unstructured":"Kohchi C, Ukena K, Tsutsui K. Ageand region-specific expressions of the messenger RNAs encoding for steroidogenic enzymes P450scc, P450c17 and 3\u03b2-HSD in the postnatal rat brain. Brain Res. 1998;801:233\u20138.","journal-title":"Brain Res"},{"key":"5289_CR53","first-page":"49","volume":"4","author":"K Tsutsui","year":"1999","unstructured":"Tsutsui K, Ukena K. Neurosteroids in the cerebellar Purkinje neuron and their actions (review). Int J Mol Med. 1999;4:49\u201356.","journal-title":"Int J Mol Med"},{"key":"5289_CR54","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1080\/14734220310016169","volume":"2","author":"K Tsutsui","year":"2003","unstructured":"Tsutsui K, Ukena K, Sakamoto H. A novel aspect of the cerebellum: Biosynthesis of neurosteroids in the Purkinje cell (review). Cerebellum. 2003;2:215\u201322.","journal-title":"The Cerebellum"},{"key":"5289_CR55","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.neures.2004.03.006","volume":"49","author":"K Tsutsui","year":"2004","unstructured":"Tsutsui K, Sakamoto H, Shikimi H, Ukena K. Organizing actions of neurosteroids in the Purkinje neuron (review). Neurosci Res. 2004;49:273\u20139.","journal-title":"Neurosci Res"},{"key":"5289_CR56","doi-asserted-by":"publisher","first-page":"3578","DOI":"10.1210\/en.142.8.3578","volume":"142","author":"T Kimoto","year":"2001","unstructured":"Kimoto T, Tsurugizawa T, Ohta Y, Makino J, Tamura H, Hojo Y, Takata N, Kawato S. Neurosteroid synthesis by cytochrome P450-containing systems localized in the rat brain hippocampal neurons: N-methyl-D-aspartate and calciumdependent synthesis. Endocrinology. 2001;142:3578\u201389.","journal-title":"Endocrinology"},{"key":"5289_CR57","doi-asserted-by":"publisher","first-page":"865","DOI":"10.1073\/pnas.2630225100","volume":"101","author":"Y Hojo","year":"2004","unstructured":"Hojo Y, Hattori TA, Enami T, Furukawa A, Suzuki K, Ishii HT, Mukai H, Morrison JH, Janssen WG, Kominami S, Harada N, Kimoto T, Kawato S. Adult male rat hippocampus synthesizes estradiol from pregnenolone by cytochromes P45017\u03b1 and P450 aromatase localized in neurons. Proc Natl Acad Sci USA. 2004; 101:865\u201370.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5289_CR58","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1046\/j.1471-4159.1994.63010086.x","volume":"63","author":"P Guarneri","year":"1994","unstructured":"Guarneri P, Guarneri R, Cascio C, Pavasant P, Piccoli F, Papadopoulos V. Neurosteroidogenesis in rat retinas. J Neurochem. 1994;63:86\u201396.","journal-title":"J Neurochem"},{"key":"5289_CR59","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1002\/cne.901450305","volume":"145","author":"J Altman","year":"1972","unstructured":"Altman J. Postnatal development of the cerebellar cortex in the rat. I. The external germinal layer and the transitional molecular layer. J Comp Neurol. 1972;145:353\u201397.","journal-title":"J Comp Neurol"},{"key":"5289_CR60","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1002\/cne.901450402","volume":"145","author":"J Altman","year":"1972","unstructured":"Altman J. Postnatal development of the cerebellar cortex in the rat. II. Phases in the maturation of Purkinje cells and of the molecular layer. J Comp Neurol. 1972;145:399\u2013463.","journal-title":"J Comp Neurol"},{"key":"5289_CR61","doi-asserted-by":"crossref","first-page":"6221","DOI":"10.1523\/JNEUROSCI.21-16-06221.2001","volume":"21","author":"H Sakamoto","year":"2001","unstructured":"Sakamoto H, Ukena K, Tsutsui K. Effects of progesterone synthesizedde novo in the developing Purkinje cell on its dendritic growth and synaptogenesis. J Neurosci. 2001;21:6221\u201332.","journal-title":"J Neurosci"},{"key":"5289_CR62","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/S0304-3940(02)00077-0","volume":"322","author":"H Sakamoto","year":"2002","unstructured":"Sakamoto H, Ukena K, Tsutsui K. Dendritic spine formation in response to progesterone synthesized de novo in the developing Purkinje cell in rats. Neurosci Lett. 2002;322:111\u201315.","journal-title":"Neurosci Lett"},{"key":"5289_CR63","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0304-3940(03)00362-8","volume":"343","author":"H Sakamoto","year":"2003","unstructured":"Sakamoto H, Shikimi H, Ukena K, Tsutsui K. Neonatal expression of progesterone receptor isoforms in the cerebellar Purkinje cell in rats. Neurosci Lett. 2003;343:163\u20136.","journal-title":"Neurosci Lett"},{"key":"5289_CR64","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.neuroscience.2004.04.003","volume":"126","author":"H Sakamoto","year":"2004","unstructured":"Sakamoto H, Ukena K, Takemori H, Okamoto M, Kawata M, Tsutsui K. Expression and localization of 25-Dx, a membrane-associated putative progesterone-binding protein, in the developing Purkinje cell. Neuroscience. 2004;126:325\u201334.","journal-title":"Neuroscience"},{"key":"5289_CR65","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/S0304-3940(00)01221-0","volume":"288","author":"RH Price","year":"2000","unstructured":"Price RH, Handa RJ. Expression of estrogen receptor-\u03b2 protein and mRNA in the cerebellum of the rat. Neurosci Lett. 2000;288:115\u201318.","journal-title":"Neurosci Lett"},{"key":"5289_CR66","doi-asserted-by":"publisher","first-page":"3306","DOI":"10.1073\/pnas.052707299","volume":"99","author":"C Orikasa","year":"2002","unstructured":"Orikasa C, Kondo Y, Hayashi S, McEwen BS, Sakuma Y. Sexually dimorphic expression of estrogen receptor \u03b2 in the anteroventral periventricular nucleus of the rat preoptic area: implication in luteinizing hormone surge. Proc Natl Acad Sci USA. 2002;99:3306\u201309.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5289_CR67","doi-asserted-by":"publisher","first-page":"5098","DOI":"10.1210\/en.2003-0267","volume":"144","author":"Y Ikeda","year":"2003","unstructured":"Ikeda Y, Nagai A, Ikeda MA, Hayashi S. Sexually dimorphic and estrogen-dependent expression of estrogen receptor beta in the ventromedial hypothalamus during rat postnatal development. Endocrinology. 2003;144:5098\u2013115.","journal-title":"Endocrinology"},{"key":"5289_CR68","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1523\/JNEUROSCI.10-04-01286.1990","volume":"10","author":"E Gould","year":"1990","unstructured":"Gould E, Woolley CS, Frankfurt M, McEwen BS. Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood. J Neurosci. 1990;10:1286\u201391.","journal-title":"J Neurosci"},{"key":"5289_CR69","doi-asserted-by":"crossref","first-page":"4035","DOI":"10.1523\/JNEUROSCI.10-12-04035.1990","volume":"10","author":"CS Woolley","year":"1990","unstructured":"Woolley CS, Gould E, Frankfurt M, McEwen BS. Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons. J Neurosci. 1990;10:4035\u20139.","journal-title":"J Neurosci"},{"key":"5289_CR70","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1523\/JNEUROSCI.12-07-02549.1992","volume":"12","author":"CS Woolley","year":"1992","unstructured":"Woolley CS, McEwen BS. Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat. J Neurosci. 1992;12:2549\u201354.","journal-title":"J Neurosci"},{"key":"5289_CR71","doi-asserted-by":"crossref","first-page":"7680","DOI":"10.1523\/JNEUROSCI.14-12-07680.1994","volume":"14","author":"CS Woolley","year":"1994","unstructured":"Woolley CS, McEwen BS. Estradiol regulates hippocampal dendritic spine density via an N-methyl-D-aspartate receptordependent mechanism. J Neurosci. 1994;14:7680\u20137.","journal-title":"J Neurosci"},{"key":"5289_CR72","doi-asserted-by":"publisher","first-page":"7093","DOI":"10.1073\/pnas.121146898","volume":"98","author":"BS McEwen","year":"2001","unstructured":"McEwen BS, Akama K, Alves S, Brake WG, Bulloch K, Lee S, Li C, Yuen G, Milner TA. Tracking the estrogen receptor in neurons: implications for estrogen-induced synapse formation (review). Proc Natl Acad Sci USA. 2001;98:7093\u2013100.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5289_CR73","doi-asserted-by":"crossref","first-page":"4059","DOI":"10.1523\/JNEUROSCI.16-13-04059.1996","volume":"16","author":"DD Murphy","year":"1996","unstructured":"Murphy DD, Segal M. Regulation of dendritic spine density in cultured rat hippocampal neurons by steroid hormones. J Neurosci. 1996;16:4059\u201368.","journal-title":"J Neurosci"},{"key":"5289_CR74","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/0006-8993(93)90771-E","volume":"608","author":"J P\u2019erez","year":"1993","unstructured":"P\u2019erez J, Luqu\u2019yn S, Naftolin F, Garc\u2019ya-Segura LM. The role of estradiol and progesterone in phased synaptic remodelling of the rat arcuate nucleus. Brain Res. 1993;608:38\u201344.","journal-title":"Brain Res"},{"key":"5289_CR75","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/0006-8993(94)90159-7","volume":"641","author":"MC Langub","year":"1994","unstructured":"Langub MC, Maley BE, Watson RE. Estrous cycle-associated axosomatic synaptic plasticity upon estrogen receptive neurons in the rat preoptic area. Brain Res. 1994;641:303\u201310.","journal-title":"Brain Res"},{"key":"5289_CR76","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0169-328X(93)90065-W","volume":"17","author":"N Rocamora","year":"1993","unstructured":"Rocamora N, Garcia-Ladona FJ, Palacios JM, Mengod G. Differential expression of brain-derived neurotrophic factor, neurotrophin-3, and low-affinity nerve growth factor receptor during the postnatal development of the rat cerebellar system. Mol Brain Res. 1993;17:1\u20138.","journal-title":"Mol Brain Res"},{"key":"5289_CR77","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1038\/368147a0","volume":"368","author":"P Ernfors","year":"1994","unstructured":"Ernfors P, Lee KF, Jaenisch R. Mice lacking brain-derived neurotrophic factor develop with sensory deficits. Nature. 1994;368:147\u201350.","journal-title":"Nature"},{"key":"5289_CR78","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S0896-6273(00)80938-1","volume":"19","author":"PM Schwartz","year":"1997","unstructured":"Schwartz PM, Borghesani PR, Levy RL, Pomeroy SL, Segal RA. Abnormal cerebellar development and foliation in BDNF-\/mice reveals a role for neurotrophins in CNS patterning. Neuron. 1997;19:269\u201381.","journal-title":"Neuron"},{"key":"5289_CR79","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1038\/5669","volume":"2","author":"B Bates","year":"1999","unstructured":"Bates B, Rios M, Trumpp A, Chen C, Fan G, Bishop JM, Jaenisch R. Neurotrophin-3 is required for proper cerebellar development. Nat Neurosci. 1999;2:115\u201317.","journal-title":"Nat Neurosci"},{"key":"5289_CR80","doi-asserted-by":"publisher","first-page":"7953","DOI":"10.1073\/pnas.1332667100","volume":"100","author":"AM Ghoumari","year":"2003","unstructured":"Ghoumari AM, Dusart I, El-Etr M, Tronche F, Sotelo C, Schumacher M, Baulieu EE. Mifepristone (RU486) protects Purkinje cells from cell death in organotypic slice cultures of postnatal rat and mouse cerebellum. Proc Natl Acad Sci USA. 2003;100:7953\u20138.","journal-title":"Proc Natl Acad Sci USA"},{"key":"5289_CR81","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/nm1073","volume":"10","author":"LD Griffin","year":"2004","unstructured":"Griffin LD, Gong W, Verot L, Mellon SH. Niemann-Pick type C disease involves disrupted neurosteroidogenesis and responds to allopregnanolone. Nat Med. 2004;10:704\u201311.","journal-title":"Nat Med"},{"key":"5289_CR82","first-page":"3611","volume-title":"The metabolic and molecular bases of inherited disease","author":"MC Patterson","year":"2001","unstructured":"Patterson MC, Vanier MT, Suzuki K, Morris JA, Carstea E, Neufeld EB, Blanchette-Mackie JE, Pentchv PG. A lipid trafficking disorder. In: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The metabolic and molecular bases of inherited disease, 8th ed. New York: McGraw-Hill, 2001:3611\u201333.","edition":"8th ed."}],"container-title":["The Cerebellum"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1080\/14734220600697211.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1080\/14734220600697211\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.springerlink.com\/index\/pdf\/10.1080\/14734220600697211","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1080\/14734220600697211.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,9]],"date-time":"2025-01-09T09:27:15Z","timestamp":1736414835000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1080\/14734220600697211"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":82,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["5289"],"URL":"https:\/\/doi.org\/10.1080\/14734220600697211","relation":{},"ISSN":["1473-4222","1473-4230"],"issn-type":[{"value":"1473-4222","type":"print"},{"value":"1473-4230","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]}}}