{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T22:35:58Z","timestamp":1793831758894,"version":"4.6.1"},"reference-count":154,"publisher":"Informa UK Limited","issue":"6","license":[{"start":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T00:00:00Z","timestamp":1684108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Neurotherapeutics"],"published-print":{"date-parts":[[2023,6,3]]},"DOI":"10.1080\/14737175.2023.2211767","type":"journal-article","created":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T05:55:16Z","timestamp":1684130116000},"page":"535-548","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":68,"title":["Pharmacological Treatment of Generalised Anxiety Disorder: Current Practice and Future Directions"],"prefix":"10.1080","volume":"23","author":[{"given":"Harry A.","family":"Fagan","sequence":"first","affiliation":[{"name":"Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK"},{"name":"College Keep, Southern Health NHS Foundation Trust, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Baldwin","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Sciences (CNS and Psychiatry), Faculty of Medicine, University of Southampton, Southampton, UK"},{"name":"College Keep, Southern Health NHS Foundation Trust, Southampton, UK"},{"name":"Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,5,15]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2017.19.2\/macrocq"},{"key":"cit0002","volume-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"1980","edition":"3"},{"key":"cit0003","volume-title":"The ICD-10 Classification of Mental and Behavioural Disorders","author":"World Health Organization (WHO)","year":"1993"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"cit0005","volume-title":"ICD-11: international Classification of Diseases","author":"World Health Organization (WHO)","year":"2022","edition":"11"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.62.6.617"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2005.04.012"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2017.0056"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)02143-7"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2014.06.021"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01161-7"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(90)90133-P"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1991.01810260065010"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(94)02510-P"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1002\/9781119189909.ch8"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1017\/S003329171200147X"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2011.11.014"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31793-8"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1111\/j.2044-8341.1959.tb00467.x"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1177\/0269881115581093"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114525674"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1159\/000447034"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.5694\/mja2.50522"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09r05786blu"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1016\/j.psym.2017.10.009"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2429"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2017.1359257"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.2165\/00023210-200923050-00006"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2008.00067.x"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.07.001"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200868050-00011"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.22170"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0327(87)90018-8"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.2165\/11634510-000000000-00000"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-014-0192-0"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01432-7"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2022.07.009"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2010.02966.x"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-015-0303-6"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2017.08.430"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l2147"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v63n1112"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050731"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(05)80248-9"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1157.1999.tb02087.x"},{"issue":"13","key":"cit0046","first-page":"5","volume":"63","author":"Nemeroff CB","year":"2002","journal-title":"J Clin Psychiatry"},{"issue":"8","key":"cit0047","first-page":"31","volume":"61","author":"Garver DL","year":"2000","journal-title":"J Clin Psychiatry"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1016\/j.janxdis.2011.01.002"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1177\/0269881113503509"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1611832"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1111\/add.15695"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2009.00109.x"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1080\/15622975.2022.2086295"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.d1199"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-984400"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2015.17.2\/proybyrne"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01200-3"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1002\/da.22895"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.07.005"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e328350b133"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2019.08.014"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2022.2125800"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2012.03.024"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v67n0818"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1177\/0269881117699361"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.11.008"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.162.1.146"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.107.037788"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1002\/gps.3867"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2016.06.006"},{"key":"cit0071","volume-title":"Mental health of children and young people in Great Britain","author":"Green H","year":"2005"},{"key":"cit0072","first-page":"1002","volume":"2016","author":"Gale CK","year":"2016","journal-title":"BMJ Clin Evid"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1491966"},{"key":"cit0074","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j3927"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v64n0305"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145705005973"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2008.05.002"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.170"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.11m07493"},{"key":"cit0080","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e3283530ad7"},{"key":"cit0081","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e3282f0f0d7"},{"key":"cit0082","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e32833e34d9"},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2009.05.004"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2020.595584"},{"key":"cit0085","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2016.146"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-199304000-00009"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2018.01.020"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S366048"},{"key":"cit0089","unstructured":"Fabre-Kramer pipeline [Internet]. Houston (TX): fabre-Kramer Pharmaceuticals; [cited 2023 Mar 15]. Available from: https:\/\/fabrekramer.com\/pipeline\/#1489503963784-5b2be039-5ceed3eb-d2400966-8526."},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.011478"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.12.009"},{"key":"cit0092","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19010035"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116675512"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2010.116"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116675513"},{"key":"cit0096","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.08.025"},{"key":"cit0097","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2012.08.003"},{"key":"cit0098","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01312"},{"key":"cit0099","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)57004-9"},{"key":"cit0100","unstructured":"NCT00807937. Proof of concept in patients with generalized anxiety disorder (GAD)AZD7325 [Internet]. Bethesda (MD): U.S. National Library of Medicine; [cited 2023 Mar 17]. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT00807937"},{"key":"cit0101","unstructured":"NCT00808249. AZD7325 proof of concept in patients with generalized anxiety disorder (GAD) [Internet]. Bethesda (MD): U.S. National Library of Medicine; [cited 2023 Mar 17]. Available from: https:\/\/www.clinicaltrials.gov\/ct2\/show\/results\/NCT00808249?view=results"},{"key":"cit0102","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0000000000000997"},{"key":"cit0103","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20081251"},{"key":"cit0104","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011612.pub3"},{"key":"cit0105","doi-asserted-by":"publisher","DOI":"10.1177\/0269881117705089"},{"key":"cit0106","doi-asserted-by":"publisher","DOI":"10.1177\/0269881118762073"},{"key":"cit0107","doi-asserted-by":"publisher","DOI":"10.1177\/20451253211056743"},{"key":"cit0108","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301531"},{"key":"cit0109","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2016.01.009"},{"key":"cit0110","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2015.09.008"},{"key":"cit0111","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx109"},{"key":"cit0112","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800213-1.00018-3"},{"key":"cit0113","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-006-0335-9"},{"key":"cit0114","doi-asserted-by":"publisher","DOI":"10.1017\/S1461145712000065"},{"key":"cit0115","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2009.10.005"},{"key":"cit0116","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2010.11.012"},{"key":"cit0117","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2006.06.019"},{"key":"cit0118","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4556-2"},{"key":"cit0119","doi-asserted-by":"publisher","DOI":"10.1002\/da.20695"},{"key":"cit0120","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.03.023"},{"key":"cit0121","doi-asserted-by":"publisher","DOI":"10.1007\/s11920-017-0819-1"},{"key":"cit0122","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.06.004"},{"key":"cit0123","doi-asserted-by":"crossref","first-page":"S324","DOI":"10.1038\/npp.2011.293","volume":"36","author":"Serrano VF","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"cit0124","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00357"},{"key":"cit0125","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2013.00028"},{"key":"cit0126","doi-asserted-by":"publisher","DOI":"10.1002\/hup.2436"},{"key":"cit0127","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2015.06.005"},{"key":"cit0128","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2075"},{"key":"cit0129","doi-asserted-by":"publisher","DOI":"10.1080\/13651501.2019.1711425"},{"key":"cit0130","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0415-8"},{"key":"cit0131","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-00937-9"},{"key":"cit0132","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2020.110166"},{"key":"cit0133","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02090-x"},{"issue":"3","key":"cit0134","first-page":"30","volume":"14","author":"Nakamura M","year":"2017","journal-title":"Innov Clin Neurosci"},{"key":"cit0135","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-022-00974-6"},{"key":"cit0136","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2020.22.3\/mcrocq"},{"key":"cit0137","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2009.07.006"},{"key":"cit0138","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-015-0387-1"},{"key":"cit0139","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(19)30401-8"},{"key":"cit0140","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.6"},{"key":"cit0141","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2014.11.002"},{"key":"cit0142","doi-asserted-by":"publisher","DOI":"10.1002\/hup.1259"},{"key":"cit0143","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-027925"},{"key":"cit0144","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.06.001"},{"key":"cit0145","doi-asserted-by":"publisher","DOI":"10.1159\/000510853"},{"key":"cit0146","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00103"},{"key":"cit0147","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2006.163.11.1905"},{"key":"cit0148","doi-asserted-by":"publisher","DOI":"10.1002\/wps.21056"},{"key":"cit0149","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-017-0423-2"},{"key":"cit0150","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-019-0445-1"},{"key":"cit0151","doi-asserted-by":"publisher","DOI":"10.1177\/0269881111408455"},{"key":"cit0152","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2012.001"},{"key":"cit0153","doi-asserted-by":"publisher","DOI":"10.1159\/000119004"},{"key":"cit0154","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-017-0463-6"}],"container-title":["Expert Review of Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14737175.2023.2211767","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T10:07:54Z","timestamp":1685959674000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14737175.2023.2211767"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,15]]},"references-count":154,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,6,3]]}},"alternative-id":["10.1080\/14737175.2023.2211767"],"URL":"https:\/\/doi.org\/10.1080\/14737175.2023.2211767","relation":{},"ISSN":["1473-7175","1744-8360"],"issn-type":[{"value":"1473-7175","type":"print"},{"value":"1744-8360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,15]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iern20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iern20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}