{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:31:04Z","timestamp":1790397064523,"version":"4.1.0"},"reference-count":74,"publisher":"Informa UK Limited","issue":"2","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Lundbeck Italia"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Neurotherapeutics"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1080\/14737175.2025.2602193","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T08:32:54Z","timestamp":1766997174000},"page":"175-184","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["Vortioxetine\u2019s cardiovascular profile as a relevant feature for the management of major depressive disorder in comorbidity with organic diseases"],"prefix":"10.1080","volume":"26","author":[{"given":"Bernardo","family":"Dell\u2019osso","sequence":"first","affiliation":[{"name":"University of Milan","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Blasi","sequence":"additional","affiliation":[{"name":"University of Bari \u201cAldo Moro\u201d","place":["Bari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Serafini","sequence":"additional","affiliation":[{"name":"University of Genoa","place":["Genoa, Italy"]},{"name":"IRCCS Ospedale Policlinico San Martino","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Serrati","sequence":"additional","affiliation":[{"name":"DIAR Neuroscienze","place":["Regione Liguria, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Bianchetti","sequence":"additional","affiliation":[{"name":"Fondazione Teresa Camplani, Domus Salutis Hospital","place":["Brescia, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Italo","family":"Porto","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino","place":["Genoa, Italy"]},{"name":"University of Genoa","place":["Genoa, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni Battista","family":"Forleo","sequence":"additional","affiliation":[{"name":"Ospedale Fatebenefratelli","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pugliese","sequence":"additional","affiliation":[{"name":"Lundbeck Italia","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Mastrostefano","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdinando","family":"Nicoletti","sequence":"additional","affiliation":[{"name":"Sapienza University of Rome","place":["Rome, Italy"]},{"name":"IRCCS Neuromed","place":["Pozzilli, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,12,29]]},"reference":[{"key":"e_1_3_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01738-y"},{"key":"e_1_3_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20723"},{"issue":"5","key":"e_1_3_6_5_1","first-page":"381","article-title":"Sleep and Parkinson disease","volume":"114","author":"Bollu PC","year":"2017","unstructured":"Bollu PC, Sahota P. Sleep and Parkinson disease. Mo Med. 2017;114(5):381\u2013386. Available from: https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC6140019\/","journal-title":"Mo Med"},{"key":"e_1_3_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0891988704267456"},{"key":"e_1_3_6_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_3_6_8_1","unstructured":"World Health Organization. Depression. Geneva: World Health Organization; 2023. [cited 2025 Oct]. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression"},{"key":"e_1_3_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.03.082"},{"key":"e_1_3_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)31678-6"},{"key":"e_1_3_6_11_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291709990213"},{"key":"e_1_3_6_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/fampra\/cmv037"},{"key":"e_1_3_6_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-0200-2"},{"key":"e_1_3_6_14_1","first-page":"123","volume-title":"Depression as a systemic illness","author":"Kanner AM","year":"2018","unstructured":"Kanner AM. Depression in neurological disorders: comorbidity or another clinical manifestation? In: Strain J Blumenfield M, editors. Depression as a systemic illness. New York (NY): Oxford University Press; 2018. p. 123\u2013143. Available from https:\/\/academic.oup.com\/book\/doi\/10.1093\/med\/9780199793624.001.0001"},{"key":"e_1_3_6_15_1","unstructured":"US Food and Drug Administration. Drug approval package: brintellix (vortioxetine) tablets. Company: takeda Pharmaceuticals USA Inc.; application no.: 204447. Silver Spring (MD): Food and Drug Administration; 2013. [cited 2025 Oct]. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/nda\/2013\/204447Orig1s000TOC.cfm"},{"key":"e_1_3_6_16_1","unstructured":"European Medicines Agency. Brintellix (vortioxetine): assessment report for an initial marketing authorisation application. Procedure no. EMEA\/H\/C\/002717. Applicant: h. Lundbeck A\/S. 2013. [cited 2025 Oct]. Available from: https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/brintellix"},{"key":"e_1_3_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2020.11.106"},{"key":"e_1_3_6_18_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.23.1086"},{"key":"e_1_3_6_19_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S296451"},{"key":"e_1_3_6_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00017"},{"key":"e_1_3_6_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-023-05439-8"},{"key":"e_1_3_6_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyx070"},{"key":"e_1_3_6_23_1","doi-asserted-by":"publisher","DOI":"10.1177\/07067437241245384"},{"key":"e_1_3_6_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.52"},{"key":"e_1_3_6_25_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.16m10744"},{"key":"e_1_3_6_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/YIC.0b013e3283542457"},{"key":"e_1_3_6_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116628440"},{"key":"e_1_3_6_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-7843.2012.00886.x"},{"key":"e_1_3_6_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2014.07.00"},{"key":"e_1_3_6_30_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2015.1046836"},{"key":"e_1_3_6_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-017-0612-7"},{"key":"e_1_3_6_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.12256"},{"key":"e_1_3_6_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-013-0117-6"},{"key":"e_1_3_6_34_1","volume-title":"Brintellix (vortioxetine) product monograph","author":"Lundbeck","year":"2018","unstructured":"Lundbeck. Brintellix (vortioxetine) product monograph. Valby (DM): H. Lundbeck A\/S; 2018."},{"key":"e_1_3_6_35_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S41387"},{"key":"e_1_3_6_36_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S39544"},{"key":"e_1_3_6_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2014.12.002"},{"key":"e_1_3_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.04.023"},{"key":"e_1_3_6_39_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.161.5.826"},{"key":"e_1_3_6_40_1","doi-asserted-by":"publisher","DOI":"10.1177\/20451253211067656"},{"key":"e_1_3_6_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881118788826"},{"key":"e_1_3_6_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2023.2178082"},{"key":"e_1_3_6_43_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2019.24"},{"key":"e_1_3_6_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2023.06.024"},{"key":"e_1_3_6_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2016.03.007"},{"key":"e_1_3_6_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/pcn5.70088"},{"key":"e_1_3_6_47_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881115581093"},{"key":"e_1_3_6_48_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1092852915000553"},{"key":"e_1_3_6_49_1","first-page":"3","volume-title":"Depression in medical illness","author":"Bui M","year":"2016","unstructured":"Bui M, Mufson M, Gitlin D. Relationships between depression and medical illness. In: Barsky A, Silbersweig D Boland R, editors. Depression in medical illness. New York (NY): McGraw-Hill Education; 2016. p. 3\u201313."},{"key":"e_1_3_6_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.641491"},{"key":"e_1_3_6_51_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43045-023-00369-4"},{"key":"e_1_3_6_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-3223(03)00587-0"},{"key":"e_1_3_6_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-020-00763-z"},{"key":"e_1_3_6_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2016.181"},{"key":"e_1_3_6_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2022.05.098"},{"key":"e_1_3_6_56_1","unstructured":"National Institute for Health and Care Excellence (NICE). Depression in adults: treatment and management. London: National Institute for Health and Care Excellence; 2022 Jun 29. [cited 2025 Oct]. Available from: https:\/\/www.nice.org.uk\/guidance\/ng222"},{"key":"e_1_3_6_57_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyad018"},{"key":"e_1_3_6_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci12111466"},{"key":"e_1_3_6_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2021.02.075"},{"key":"e_1_3_6_60_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-025-07987-1"},{"key":"e_1_3_6_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm14090918"},{"key":"e_1_3_6_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2017.1334765"},{"key":"e_1_3_6_63_1","first-page":"183","article-title":"Antidepressants, QT interval and cardiovascular risk: justified concerns?","volume":"18","author":"Schwartz PJ","year":"2012","unstructured":"Schwartz PJ, Altamura AC. Antidepressants, QT interval and cardiovascular risk: justified concerns? J Psychopathol. 2012 [cited 2025 Oct];18:183\u2013191. Available from: https:\/\/www.jpsychopathol.it\/article\/antidepressants-qt-interval-and-cardiovascular-risk-justified-concerns\/","journal-title":"J Psychopathol"},{"key":"e_1_3_6_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e318191c6a8"},{"key":"e_1_3_6_65_1","doi-asserted-by":"publisher","DOI":"10.33450\/fpn.2021.02.004"},{"key":"e_1_3_6_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.51"},{"key":"e_1_3_6_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-020-02546-8"},{"key":"e_1_3_6_68_1","doi-asserted-by":"publisher","DOI":"10.1159\/000447034"},{"key":"e_1_3_6_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2021.704281"},{"key":"e_1_3_6_70_1","doi-asserted-by":"publisher","DOI":"10.1192\/j.eurpsy.2024.11"},{"key":"e_1_3_6_71_1","doi-asserted-by":"publisher","DOI":"10.1708\/2040.22160"},{"key":"e_1_3_6_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40262-016-0389-0"},{"key":"e_1_3_6_73_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.09r05346blu"},{"key":"e_1_3_6_74_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200104000-00007"},{"key":"e_1_3_6_75_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.118.007811"},{"key":"e_1_3_6_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaac.2022.01.004"}],"updated-by":[{"DOI":"10.1080\/14737175.2026.2618409","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000}}],"container-title":["Expert Review of Neurotherapeutics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14737175.2025.2602193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T09:02:38Z","timestamp":1770022958000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14737175.2025.2602193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,29]]},"references-count":74,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1080\/14737175.2025.2602193"],"URL":"https:\/\/doi.org\/10.1080\/14737175.2025.2602193","relation":{},"ISSN":["1473-7175","1744-8360"],"issn-type":[{"value":"1473-7175","type":"print"},{"value":"1744-8360","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,29]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iern20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=iern20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-10-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}