{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:54:54Z","timestamp":1787007294291,"version":"build-2736575974"},"reference-count":68,"publisher":"Informa UK Limited","issue":"6","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Safety"],"published-print":{"date-parts":[[2021,6,3]]},"DOI":"10.1080\/14740338.2021.1867100","type":"journal-article","created":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T07:15:34Z","timestamp":1609744534000},"page":"651-667","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":11,"title":["Safety of current immune checkpoint inhibitors in non-small cell lung cancer"],"prefix":"10.1080","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4477-3633","authenticated-orcid":false,"given":"Pamela","family":"Abdayem","sequence":"first","affiliation":[{"name":"Department of Cancer Medicine, Thoracic Oncology Unit, Gustave Roussy Cancer Campus, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Planchard","sequence":"additional","affiliation":[{"name":"Department of Cancer Medicine, Thoracic Oncology Unit, Gustave Roussy Cancer Campus, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,3,25]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar4060"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.03.006"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1016\/j.annonc.2020.08.2051"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2019-0071"},{"key":"cit0005","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2020.38.15_suppl.9501"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1917346"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdv623"},{"key":"cit0008","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx225"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdx286"},{"key":"cit0010","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.66.1389"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70334-1"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1007\/s11523-020-00738-6"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504030"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.3923"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.1093\/clinchem\/hvaa081"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30673-9"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1504627"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1507643"},{"key":"cit0019","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)32517-X"},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01281-7"},{"key":"cit0021","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1613493"},{"key":"cit0022","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32409-7"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606774"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910231"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.0237"},{"key":"cit0026","author":"Barlesi F","journal-title":"Annals of Oncology. 29. 10.1093\/annonc\/mdy424.066.\u00a0"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30084-0"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtho.2020.03.028"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1810865"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1801005"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(19)30167-6"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709937"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-5701-6"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31043"},{"key":"cit0035","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.04.177"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1097\/CAD.0000000000000921"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2018.11.72"},{"key":"cit0038","unstructured":"Cortellini A, Friedlaender A, Banna GL, et al. Immune-related Adverse Events of Pembrolizumab in a Large Real-world Cohort of Patients With NSCLC With a PD-L1 Expression \u2265 50% and Their Relationship With Clinical Outcomes. Clin Lung Cancer. 2020;21(6)."},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2020.01.003"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.11.019"},{"issue":"9","key":"cit0041","first-page":"1628","volume":"14","author":"Spigel DR","year":"2019","journal-title":"J Thorac Oncol Off Publ Int Assoc Study Lung Cancer"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2018.05.015"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyaa152"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-1741"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000422020"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.77.6385"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.47.1946"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000019013"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2020-001145"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.6737"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(20)30314-4"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.6026\/97320630016219"},{"issue":"6","key":"cit0053","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1158\/2159-8290.CD-20-0422","volume":"10","author":"Dai M","year":"2020","journal-title":"Cancer Discov"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2020.100016"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.02.010"},{"key":"cit0056","unstructured":"Gustave Roussy, Cancer Campus, Grand Paris. Predictive markers of immune-related adverse events in patients treated with immune stimulatory drugs [Internet]. Report No.: NCT03984318. clinicaltrials.gov; 2019 Jun cited 2020 Sep 30. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03984318"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-200205000-00005"},{"issue":"3","key":"cit0058","first-page":"328","volume":"14","author":"Ferrara R","year":"2019","journal-title":"J Thorac Oncol Off Publ Int Assoc Study Lung Cancer"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2018.3676"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1158\/2326-6066.CIR-17-0755"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2019.1022"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2018.79.0006"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.160099797"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1038\/nature19330"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1007\/s00280-019-03993-1"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdy103"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdr587"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1136\/esmoopen-2020-000820"}],"container-title":["Expert Opinion on Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14740338.2021.1867100","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T06:02:41Z","timestamp":1670652161000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14740338.2021.1867100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,25]]},"references-count":68,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,6,3]]}},"alternative-id":["10.1080\/14740338.2021.1867100"],"URL":"https:\/\/doi.org\/10.1080\/14740338.2021.1867100","relation":{},"ISSN":["1474-0338","1744-764X"],"issn-type":[{"value":"1474-0338","type":"print"},{"value":"1744-764X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,25]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieds20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieds20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-10-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}