{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T17:54:04Z","timestamp":1794592444079,"version":"4.9.1"},"reference-count":110,"publisher":"Informa UK Limited","issue":"7","license":[{"start":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T00:00:00Z","timestamp":1621036800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Pharmacosmos A\/S, Holb\u00e6k, Denmark"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Safety"],"published-print":{"date-parts":[[2021,7,3]]},"DOI":"10.1080\/14740338.2021.1912010","type":"journal-article","created":{"date-parts":[[2021,5,15]],"date-time":"2021-05-15T08:49:53Z","timestamp":1621068593000},"page":"757-769","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":86,"title":["Newer formulations of intravenous iron: a review of their chemistry and key safety aspects \u2013 hypersensitivity, hypophosphatemia, and cardiovascular safety"],"prefix":"10.1080","volume":"20","author":[{"given":"Irina","family":"Blumenstein","sequence":"first","affiliation":[{"name":"Medical Department 1, Department of Gastroenterology, Hepatology, and Clinical Nutrition, University Clinic Frankfurt, Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satish","family":"Shanbhag","sequence":"additional","affiliation":[{"name":"Department of Hematology\/Medical Oncology, Cancer Specialists of North Florida, Fleming Island, FL, USA"},{"name":"Division of Hematology, Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore, MA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Langguth","sequence":"additional","affiliation":[{"name":"Institute of Pharmacy and Biochemistry, Department of Biopharmaceutics and Pharmaceutical Technology, Johannes Gutenberg University, Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7652-1572","authenticated-orcid":false,"given":"Philip A","family":"Kalra","sequence":"additional","affiliation":[{"name":"Department of Renal Medicine, Salford Royal NHS Foundation Trust, Salford, UK"},{"name":"Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinz","family":"Zoller","sequence":"additional","affiliation":[{"name":"Department of Medicine I, Gastroenterology, Hepatology and Endocrinology, Medical University of Innsbruck, Innsbruck, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Hematology and Thromboembolism, St. Joseph\u2019s Healthcare Hamilton, McMaster University, Hamilton, ON, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2021,5,15]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2010.1.338"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2016.1.57"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21154"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2011.03.016"},{"key":"cit0005","volume-title":"Summary of product characteristics","author":"Monofer (ferric derisomaltose)","year":"2020"},{"key":"cit0006","volume-title":"Product information","author":"Monoferric (ferric derisomaltose)","year":"2020"},{"key":"cit0007","volume-title":"Summary of product characteristics","author":"Ferinject (ferric carboxymaltose)","year":"2020"},{"key":"cit0008","volume-title":"Prescribing information","author":"Injectafer (ferric carboxymaltose)","year":"2020"},{"key":"cit0009","volume-title":"Prescribing information","author":"Feraheme (ferumoxytol)","year":"2020"},{"key":"cit0010","unstructured":"European Medicines Agency. Public statement. Rienso: withdrawal of the marketing authorisation in the European Union. EMA\/437901\/2015; EMEA\/H\/C\/2215. 10 Jul 2015. [cited 2021 Jan 27]. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/public-statement\/public-statement-rienso-ferumoxytol-withdrawal-marketing-authorisation-european-union_en.pdf"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000263"},{"issue":"2","key":"cit0012","first-page":"S93","volume":"15","author":"Danielson BG","year":"2004","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"cit0013","first-page":"104","volume":"1","author":"Rottembourg J","year":"2018","journal-title":"Int J Biopharm Sci"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2012.08.009"},{"key":"#cr-split#-cit0015.1","unstructured":"WO 2007\/081744 A2 - Methods and compositions for administration of iron. International Application No. PCT\/US2007\/000176. International filing date: 2007 Jan 8"},{"key":"#cr-split#-cit0015.2","unstructured":"[cited 2021 Jan 27]. Available from: https:\/\/patents.google.com\/patent\/WO2007081744A2\/en."},{"key":"#cr-split#-cit0016.1","unstructured":"US 9,376,505 B2 - Aqueous iron carbohydrate complexes, their production and medicaments containing them. Application No. 13\/556,733. International filing date: 2012 Jul 24"},{"key":"#cr-split#-cit0016.2","unstructured":"[cited 2021 Jan 27]. Available from: https:\/\/patents.google.com\/patent\/US9376505B2\/en."},{"key":"cit0017","unstructured":"Sigma-Aldrich. Product Specification. Maltodextrin 4.0\u20137.0. Product Number: 419672. [cited 2020 Sep 17]. Available from: https:\/\/www.sigmaaldrich.com\/catalog\/substance\/maltodextrin12345905036611?lang=en&region=GB."},{"key":"#cr-split#-cit0018.1","unstructured":"US 8,501,158 B2 - Polyol and polyether iron oxide complexes as pharmacological and\/or MRI contrast agents. Application No. 12\/963,308. Filing date: 2010 Dec 8"},{"key":"#cr-split#-cit0018.2","unstructured":"[cited 2021 Jan 27]. Available from: https:\/\/patents.google.com\/patent\/US8501158B2\/en."},{"key":"#cr-split#-cit0019.1","unstructured":"US 8,895,612 B2 - Methods and compositions for administration of iron. Application No. 14\/100,717. Filling date: 2013 Dec 9"},{"key":"#cr-split#-cit0019.2","unstructured":"[cited 2021 Jan 27]. Available from: https:\/\/patents.google.com\/patent\/US8895612B2\/en."},{"key":"cit0020","doi-asserted-by":"publisher","DOI":"10.1007\/s10534-015-9845-9"},{"key":"cit0021","unstructured":"British Pharmacopoeia 2017. Volume III. Jan 2017."},{"key":"cit0022","unstructured":"De Belder AN. Dextran. \u00a9 Amersham Biosciences AB 2003."},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2013.08.005"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2020.102178"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1346\/CCMN.1981.0290404"},{"key":"cit0026","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2003.08.004"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2020.250803"},{"key":"cit0028","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.22450"},{"key":"cit0029","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25060"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25564"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfaa011"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.26015"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2020.1709437"},{"key":"cit0034","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21794"},{"key":"cit0035","unstructured":"European Medicines Agency (EMA). Rapid response to BMJ. Re: pandemrix vaccine: why was the public not told of early warning signs. EMA\/659264\/2018. 2018 [cited 2021] Jan 27. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/other\/european-medicines-agency-rapid-response-british-medical-journal-pandemrix_.pdf"},{"key":"cit0036","unstructured":"OCEBM Levels of evidence working group. The Oxford 2011 Levels of Evidence."},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.111492"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1111\/vox.12773"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1111\/trf.15837"},{"key":"cit0040","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2015.10.002"},{"key":"cit0041","doi-asserted-by":"publisher","DOI":"10.1159\/000451069"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13268"},{"issue":"2","key":"cit0043","first-page":"137","volume":"17","author":"G\u00f3mez-Ram\u00edrez S","year":"2019","journal-title":"Blood Transfus"},{"key":"cit0044","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0000000000000329"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2020.100862"},{"key":"cit0046","author":"Schaefer B","year":"2020","journal-title":"Br J Clin Pharmacol"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.2147\/TCRM.S243462"},{"key":"cit0048","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1923"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124486"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2020-134435"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-BSGAbstracts.196"},{"key":"cit0052","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-020-01643-5"},{"key":"cit0053","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15386"},{"issue":"9","key":"cit0054","first-page":"1628","volume":"33","author":"Huang LL","year":"2018","journal-title":"Nephrol Dial Transplant"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.03.448"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01298-9"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneph0124"},{"key":"cit0058","doi-asserted-by":"publisher","DOI":"10.1186\/cc9215"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(88)90065-4"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1038\/bonekey.2013.231"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/468675"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1319"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbacli.2015.03.004"},{"key":"cit0064","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-012-2175-z"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2008.643"},{"key":"cit0066","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.09.050"},{"key":"cit0067","doi-asserted-by":"publisher","DOI":"10.3892\/br.2016.605"},{"issue":"1","key":"cit0068","first-page":"49","volume":"72","author":"Blazevic A","year":"2014","journal-title":"Neth J Med"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2014.20"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-219160"},{"issue":"1","key":"cit0071","first-page":"19","volume":"2019","author":"Ifie E","year":"2019","journal-title":"Endocrinol Diabetes Metab Case Rep"},{"key":"cit0072","doi-asserted-by":"publisher","DOI":"10.1136\/flgastro-2019-101242"},{"issue":"20","key":"cit0073","volume":"0211","author":"Vasquez-Rios G","year":"2020","journal-title":"Nefrologia"},{"key":"cit0074","unstructured":"Bart G, Glemarec J, Lerhun M, et al. A rusty man \u2026 or how iron can be responsible for bone pain. Symptomatic hypophosphataemic osteomalacia after iron carboxymaltose treatment. The Rheumatologist\u2019s Newsletter. No. 428;2017."},{"issue":"1","key":"cit0075","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1055\/s-0038-1636970","volume":"27","author":"Burckhardt P","year":"2018","journal-title":"Osteologie"},{"key":"cit0076","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2017-222851"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1002\/ygh2.415"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021119-034650"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2015.153"},{"issue":"2","key":"cit0080","first-page":"65","volume":"75","author":"Sari V","year":"2017","journal-title":"Neth J Med"},{"key":"cit0081","volume-title":"Prescribing information [Brazil]","author":"Ferinject (ferric carboxymaltose)","year":"2020"},{"key":"cit0082","unstructured":"GOV.UK. Drug safety update. Ferric carboxymaltose (Ferinject): risk of symptomatic hypophosphataemia leading to osteomalacia and fractures. [cited 2020 Nov 16]. Available from: https:\/\/www.gov.uk\/drug-safety-update\/ferric-carboxymaltose-ferinject-risk-of-symptomatic-hypophosphataemia-leading-to-osteomalacia-and-fractures."},{"key":"cit0083","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12301"},{"key":"cit0084","doi-asserted-by":"publisher","DOI":"10.1007\/BF02829934"},{"key":"cit0085","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-009-0051-1"},{"key":"cit0086","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9152732"},{"key":"cit0087","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0908355"},{"key":"cit0088","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu385"},{"key":"cit0089","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.027497"},{"key":"cit0090","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32339-4"},{"key":"cit0091","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gft251"},{"issue":"2","key":"cit0092","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/trf.12289","volume":"54","author":"Onken JE","year":"2014","journal-title":"Transfusion"},{"key":"cit0093","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1810742"},{"key":"cit0094","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.163"},{"key":"cit0095","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.303"},{"key":"cit0096","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.302"},{"key":"cit0097","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038516"},{"key":"cit0098","unstructured":"ClinicalTrials.gov. Intravenous iron supplement for iron deficiency in cardiac transplant recipients (IronIC). NCT03662789. 2 Mar 2020."},{"key":"cit0099","unstructured":"ClinicalTrials.gov. Intravenous iron supplement for iron deficiency in patients with severe aortic stenosis (IIISAS). NCT04206228. 3 Apr 2020."},{"key":"cit0100","unstructured":"ClinicalTrials.gov. Intravenous iron treatment in patients with heart failure and iron deficiency: IRONMAN (IRONMAN). NCT02642562. 6 Oct 2020."},{"key":"cit0101","unstructured":"ClinicalTrials.gov. Intravenous iron in patients with systolic heart failure and iron deficiency to improve morbidity & mortality (FAIR-HF2). NCT03036462. 8 May 2020."},{"key":"cit0102","unstructured":"ClinicalTrials.gov. Randomized placebo-controlled trial of FCM as treatment for heart failure with iron deficiency (HEART-FID). NCT03037931. 3 Nov 2020."},{"key":"cit0103","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-06-508325"},{"issue":"10100","key":"cit0104","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/S0140-6736(17)32154-2","volume":"390","author":"Global Burden of Disease (GBD) 2016","year":"2017","journal-title":"Lancet"},{"key":"cit0105","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez627"},{"key":"cit0106","unstructured":"CRYSVITA (burosumab). Summary of product characteristics. [cited 2020 Nov 4]. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/crysvita-epar-product-information_en.pdf"}],"container-title":["Expert Opinion on Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14740338.2021.1912010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,3]],"date-time":"2023-11-03T19:36:54Z","timestamp":1699040214000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14740338.2021.1912010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,15]]},"references-count":110,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7,3]]}},"alternative-id":["10.1080\/14740338.2021.1912010"],"URL":"https:\/\/doi.org\/10.1080\/14740338.2021.1912010","relation":{},"ISSN":["1474-0338","1744-764X"],"issn-type":[{"value":"1474-0338","type":"print"},{"value":"1744-764X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,15]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieds20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieds20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2021-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}