{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:27:04Z","timestamp":1760171224826},"reference-count":81,"publisher":"Informa UK Limited","issue":"8","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Safety"],"published-print":{"date-parts":[[2021,8,3]]},"DOI":"10.1080\/14740338.2021.1919081","type":"journal-article","created":{"date-parts":[[2021,4,21]],"date-time":"2021-04-21T04:29:37Z","timestamp":1618979377000},"page":"937-947","update-policy":"http:\/\/dx.doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":5,"title":["Drug safety in thalassemia: lessons from the present and directions for the future"],"prefix":"10.1080","volume":"20","author":[{"given":"Laura","family":"Grech","sequence":"first","affiliation":[{"name":"Centre for Molecular Medicine and Biobanking, University of Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Sultana","sequence":"additional","affiliation":[{"name":"Centre for Molecular Medicine and Biobanking, University of Malta"},{"name":"Department of Pharmacy, Mater Dei Hospital, Msida, Malta"},{"name":"Exeter College of Medicine and Health,University of Exeter, Exeter, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Borg","sequence":"additional","affiliation":[{"name":"Department of Public Health Medicine, Ministry for Health, Valletta, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Borg","sequence":"additional","affiliation":[{"name":"Department of Applied Biomedical Science, Faculty of Health Sciences, University of Malta, Imsida, Malta"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2021,5,4]]},"reference":[{"key":"cit0001","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2016.173"},{"key":"cit0002","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2017.018"},{"key":"cit0003","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-251348"},{"key":"cit0004","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-5-11"},{"issue":"1","key":"cit0005","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19010182","volume":"19","author":"Sleiman J","year":"2018","journal-title":"Int J Mol Sci"},{"key":"cit0006","doi-asserted-by":"publisher","DOI":"10.3109\/03630267909069153"},{"key":"cit0007","doi-asserted-by":"publisher","DOI":"10.1517\/21678707.2014.918503"},{"key":"cit0008","volume-title":"Guidelines for the management of non transfusion dependent thalassaemia (NTDT)","author":"Taher A","year":"2013","edition":"3"},{"key":"cit0009","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90264-X"},{"issue":"4","key":"cit0010","doi-asserted-by":"crossref","first-page":"557","DOI":"10.3324\/haematol.2009.014696","volume":"95","author":"Cappelini MD","year":"2010","journal-title":"Haematologica"},{"key":"cit0011","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200008033430503"},{"key":"cit0012","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2017.1.278"},{"key":"cit0013","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V100.2.406"},{"key":"cit0014","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011825"},{"key":"cit0015","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2017.181511"},{"key":"cit0016","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3512"},{"key":"cit0017","doi-asserted-by":"publisher","DOI":"10.1172\/JCI133678"},{"key":"cit0018","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-11-737411"},{"issue":"7","key":"cit0019","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.3324\/haematol.2018.212589","volume":"105","author":"Casu C","year":"2020","journal-title":"Haematologica"},{"issue":"5319","key":"cit0020","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1136\/bmj.2.5319.1577","volume":"2","author":"Rs SMITH","year":"1962","journal-title":"Br Med J"},{"key":"cit0021","unstructured":"Desferal\u00ae [Internet]. 2019 [updated 3rd July; cited 2020 Oct 20th]. Available from: https:\/\/www.novartis.us\/sites\/www.novartis.us\/files\/desferal.pdf"},{"key":"cit0022","volume-title":"Guidelines for the Management of Transfusion Dependent Thalassaemia (TDT)","author":"Porter J","year":"2014","edition":"3"},{"key":"cit0023","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.156.3.1899759"},{"key":"cit0024","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80556-6"},{"key":"cit0025","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.4.1229.004k32_1229_1236"},{"issue":"3","key":"cit0026","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1159\/000205991","volume":"77","author":"Warren JJ","year":"1987","journal-title":"Acta Haematol"},{"key":"cit0027","doi-asserted-by":"publisher","DOI":"10.3109\/08880019209016592"},{"key":"cit0028","unstructured":"Ferriprox [Internet]. [cited 2020 Oct 18]. Available from: https:\/\/www.ema.europa.eu\/en\/documents\/product-information\/ferriprox-epar-product-information_en.pdf"},{"issue":"7436","key":"cit0029","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1136\/bmj.328.7436.358","volume":"328","author":"Savulescu J","year":"2004","journal-title":"BMJ"},{"key":"cit0030","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03554.x"},{"key":"cit0031","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3280"},{"key":"cit0032","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-06-1867"},{"key":"cit0033","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)09740-4"},{"issue":"1","key":"cit0034","first-page":"e2018066","volume":"10","author":"Moukalled NM","year":"2018","journal-title":"Mediterr J Hematol Infect Dis"},{"issue":"6","key":"cit0035","doi-asserted-by":"crossref","first-page":"E304","DOI":"10.1002\/ajh.24353","volume":"91","author":"Origa R","year":"2016","journal-title":"Am J Hematol"},{"key":"cit0036","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2018-10-879247"},{"key":"cit0037","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-020-01341-9"},{"key":"cit0038","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1910182"},{"key":"cit0039","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2007.01399.x"},{"issue":"2","key":"cit0040","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/01.mph.0000200671.39549.2b","volume":"28","author":"Taher A","year":"2006","journal-title":"J Pediatr Hematol Oncol"},{"issue":"10","key":"cit0041","first-page":"OM01","volume":"9","author":"Keikhaei B","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"cit0042","doi-asserted-by":"publisher","DOI":"10.1016\/j.hemonc.2017.02.002"},{"key":"cit0043","doi-asserted-by":"publisher","DOI":"10.1007\/s12288-019-01231-5"},{"issue":"1","key":"cit0044","doi-asserted-by":"crossref","first-page":"e2020021","DOI":"10.4084\/mjhid.2020.021","volume":"12","author":"Yang K","year":"2020","journal-title":"Mediterr J Hematol Infect Dis"},{"key":"cit0045","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-018-3395-5"},{"key":"cit0046","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2018.198887"},{"key":"cit0047","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-06-790121"},{"issue":"1","key":"cit0048","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1172\/JCI129382","volume":"130","author":"Manolova V","year":"2019","journal-title":"J Clin Invest"},{"key":"cit0049","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25670"},{"key":"cit0050","doi-asserted-by":"publisher","DOI":"10.3810\/pgm.2011.09.2475"},{"key":"cit0051","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199410020-00001"},{"issue":"7","key":"cit0052","first-page":"873","volume":"91","author":"Piga A","year":"2006","journal-title":"Haematologica"},{"issue":"10","key":"cit0053","first-page":"1343","volume":"91","author":"Galanello R","year":"2006","journal-title":"Haematologica"},{"key":"cit0054","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13002"},{"key":"cit0055","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-11-316646"},{"key":"cit0056","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07908.x"},{"key":"cit0057","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05586.x"},{"issue":"850","key":"cit0058","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1749-6632.1998.tb10478.x","volume":"30","author":"Cohen A","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"cit0059","doi-asserted-by":"publisher","DOI":"10.1159\/000087888"},{"key":"cit0060","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3026(20)30100-9"},{"key":"cit0061","doi-asserted-by":"publisher","DOI":"10.19082\/2425"},{"key":"cit0062","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2018-024537"},{"key":"cit0063","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-018-0732-5"},{"issue":"3","key":"cit0064","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s40264-017-0606-2","volume":"41","author":"Osborne V","year":"2018","journal-title":"Drug Saf"},{"key":"cit0065","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-014-2291-x"},{"issue":"9","key":"cit0066","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.26507","volume":"64","author":"Vichinsky E","year":"2017","journal-title":"Pediatr Blood Cancer"},{"issue":"1","key":"cit0067","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.3324\/haematol.2017.176065","volume":"103","author":"Botzenhardt S","year":"2018","journal-title":"Haematologica"},{"key":"cit0068","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23715"},{"key":"cit0069","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000780"},{"key":"cit0070","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.25533"},{"issue":"2","key":"cit0071","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/ejh.13180","volume":"102","author":"Antmen B","year":"2019","journal-title":"Eur J Haematol"},{"issue":"8","key":"cit0072","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1007\/s00432-018-2665-x","volume":"144","author":"Nolte F","year":"2018","journal-title":"J Cancer Res Clin Oncol"},{"key":"cit0073","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211942"},{"issue":"2","key":"cit0074","first-page":"103","volume":"38","author":"Thakor DR","year":"2017","journal-title":"Indian J Med Paediatr Oncol"},{"key":"cit0075","doi-asserted-by":"publisher","DOI":"10.1080\/17512433.2020.1740086"},{"issue":"12","key":"cit0076","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1080\/21678707.2019.1701433","volume":"7","author":"Sultana J","year":"2017","journal-title":"Expert Opin Orphan Drugs"},{"key":"cit0077","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2019.1614165"},{"key":"cit0078","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.1833"},{"key":"cit0079","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2021.1867098"},{"issue":"5","key":"cit0080","first-page":"CD012349","volume":"8","author":"Fortin PM","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"cit0081","doi-asserted-by":"crossref","first-page":"E96","DOI":"10.1002\/ajh.25408","volume":"94","author":"Taher AT","year":"2019","journal-title":"Am J Hematol"}],"container-title":["Expert Opinion on Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14740338.2021.1919081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,3]],"date-time":"2021-09-03T11:44:55Z","timestamp":1630669495000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14740338.2021.1919081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,4]]},"references-count":81,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,8,3]]}},"alternative-id":["10.1080\/14740338.2021.1919081"],"URL":"https:\/\/doi.org\/10.1080\/14740338.2021.1919081","relation":{},"ISSN":["1474-0338","1744-764X"],"issn-type":[{"value":"1474-0338","type":"print"},{"value":"1744-764X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,4]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieds20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieds20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2020-11-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}