{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T11:11:32Z","timestamp":1793531492685,"version":"4.5.0"},"reference-count":140,"publisher":"Informa UK Limited","issue":"3","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Safety"],"published-print":{"date-parts":[[2026,3,4]]},"DOI":"10.1080\/14740338.2025.2573368","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T09:37:05Z","timestamp":1760002625000},"page":"435-451","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":2,"title":["Before you start: the safety of SGLT2 inhibitors for anti-obesity treatment"],"prefix":"10.1080","volume":"25","author":[{"given":"Ahmad Z.","family":"Al Meslamani","sequence":"first","affiliation":[{"name":"Al Ain University","place":["Abu Dhabi, United Arab Emirates"]},{"name":"Al Ain University","place":["Abu Dhabi, United Arab Emirates"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"key":"e_1_3_3_3_1","volume-title":"Endotext [Internet]","author":"Purnell JQ.","year":"2000","unstructured":"Purnell JQ. Definitions, classification, and epidemiology of obesity. In: Feingold KR, Ahmed SF, Anawalt B, et al., editors. Endotext [Internet]. South Dartmouth (MA): MDText.com, Inc; 2000 [Updated 2023 May 4]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK279167\/."},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000973"},{"key":"e_1_3_3_5_1","unstructured":"World Health Organization. Obesity and overweight [internet]. 2024 [cited 2025 Mar 1]. Available from: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/obesity-and-overweight"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-025-01734-4"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-024-01499-2"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13679-020-00422-w"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2012.675326"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1517\/14740338.2015.995088"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1514009"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-019-1057-0"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-024-00642-y"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2022.155243"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154936"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666200213123029"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00202.2018"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00264.2020"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157976"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2019.00186"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000545209"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26041670"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.1010693"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-021-01104-z"},{"key":"e_1_3_3_25_1","volume-title":"Sodium-glucose transport protein 2 (SGLT2) inhibitors","author":"Padda IS","year":"2025","unstructured":"Padda IS, Mahtani AU, Parmar M. Sodium-glucose transport protein 2 (SGLT2) inhibitors. Treasure Island (FL); 2025."},{"key":"e_1_3_3_26_1","volume-title":"Pharmacologic therapy for obesity","author":"Rodrigues Silva Sombra L","year":"2025","unstructured":"Rodrigues Silva Sombra L, Anastasopoulou C. Pharmacologic therapy for obesity. Treasure Island (FL); 2025."},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25-SREV"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40519-024-01692-2"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41073-019-0064-8"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01071-y"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.11.2901"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020962"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-018-4654-7"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2022.216"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S233538"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-0355"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.7570\/jomes21061"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.119.11684"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1356"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02539-x"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2022.100176"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01410-7"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2023.05.007"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9080904"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2023.04.012"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101337"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20051153"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.01030"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2015-1884"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.18773\/austprescr.2020.049"},{"key":"e_1_3_3_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94945-4"},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-3956-x"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2020.108136"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2023.117236"},{"key":"e_1_3_3_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.311339"},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.5603\/EP.a2021.0102"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2022-061807"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.4081\/aiua.2023.11509"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.706914"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000472021"},{"key":"e_1_3_3_62_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.048739"},{"key":"e_1_3_3_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-023-01464-6"},{"key":"e_1_3_3_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.910"},{"key":"e_1_3_3_65_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2019.2813"},{"key":"e_1_3_3_66_1","doi-asserted-by":"publisher","DOI":"10.7326\/M19-0085"},{"key":"e_1_3_3_67_1","volume-title":"Fournier gangrene","author":"Leslie SW","year":"2025","unstructured":"Leslie SW, Foreman J. Fournier gangrene. Treasure Island (FL); 2025."},{"key":"e_1_3_3_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.endinu.2019.12.007"},{"key":"e_1_3_3_69_1","volume-title":"Euglycemic diabetic ketoacidosis","author":"Plewa MC","year":"2025","unstructured":"Plewa MC, Bryant M, King-Thiele R. Euglycemic diabetic ketoacidosis. Treasure Island (FL): StatPearls Publishing; 2025."},{"key":"e_1_3_3_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00540-023-03174-8"},{"key":"e_1_3_3_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11606-024-09073-2"},{"key":"e_1_3_3_72_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-1163"},{"key":"e_1_3_3_73_1","doi-asserted-by":"publisher","DOI":"10.4081\/itjm.2024.1716"},{"key":"e_1_3_3_74_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc23-1903"},{"key":"e_1_3_3_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2023.06.103"},{"key":"e_1_3_3_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2023.11.015"},{"key":"e_1_3_3_77_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2023-003666"},{"key":"e_1_3_3_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-024-01723-6"},{"key":"e_1_3_3_79_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.120.019463"},{"key":"e_1_3_3_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBP.0000000000000479"},{"key":"e_1_3_3_81_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.19177"},{"key":"e_1_3_3_82_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S258593"},{"key":"e_1_3_3_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ipha.2025.02.001"},{"key":"e_1_3_3_84_1","doi-asserted-by":"publisher","DOI":"10.1177\/1479164120953625"},{"key":"e_1_3_3_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2019.11.005"},{"key":"e_1_3_3_86_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac210"},{"key":"e_1_3_3_87_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0201410"},{"key":"e_1_3_3_88_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1611925"},{"key":"e_1_3_3_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)02074-8"},{"key":"e_1_3_3_90_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-021-01276-9"},{"key":"e_1_3_3_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15901"},{"key":"e_1_3_3_92_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20210700"},{"key":"e_1_3_3_93_1","volume-title":"Acute kidney injury","author":"Goyal A","year":"2025","unstructured":"Goyal A, Daneshpajouhnejad P, Hashmi MF, et al. Acute kidney injury. Treasure Island (FL); 2025."},{"key":"e_1_3_3_94_1","unstructured":"US FDA. Fda drug safety communication: fda strengthens kidney warnings for diabetes medicines canagliflozin (Invokana Invokamet) and dapagliflozin (Farxiga Xigduo XR). 2016. Available from: https:\/\/www.fda.gov\/drugs\/drug-safety-and-availability\/fda-drug-safety-communication-fda-strengthens-kidney-warnings-diabetes-medicines-canagliflozin"},{"key":"e_1_3_3_95_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2025.2471529"},{"key":"e_1_3_3_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-022-03211-7"},{"key":"e_1_3_3_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-024-03623-7"},{"key":"e_1_3_3_98_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002983"},{"key":"e_1_3_3_99_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2021.09.015"},{"key":"e_1_3_3_100_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2024816"},{"key":"e_1_3_3_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabet.2021.101285"},{"key":"e_1_3_3_102_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.30762"},{"key":"e_1_3_3_103_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.918350"},{"key":"e_1_3_3_104_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.16171221"},{"key":"e_1_3_3_105_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2020-001856"},{"key":"e_1_3_3_106_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.713192"},{"key":"e_1_3_3_107_1","doi-asserted-by":"publisher","DOI":"10.7326\/M22-2115"},{"key":"e_1_3_3_108_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00367.2024"},{"key":"e_1_3_3_109_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc18-0680"},{"key":"e_1_3_3_110_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12428"},{"key":"e_1_3_3_111_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1911303"},{"key":"e_1_3_3_112_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2107038"},{"key":"e_1_3_3_113_1","doi-asserted-by":"publisher","DOI":"10.1159\/000530395"},{"key":"e_1_3_3_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2024.156113"},{"key":"e_1_3_3_115_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16275"},{"key":"e_1_3_3_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(24)00272-9"},{"key":"e_1_3_3_117_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13300-023-01481-7"},{"key":"e_1_3_3_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-019-05065-8"},{"key":"e_1_3_3_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801443"},{"key":"e_1_3_3_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.16235"},{"key":"e_1_3_3_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1085799"},{"key":"e_1_3_3_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2020.07.008"},{"key":"e_1_3_3_123_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.59965"},{"key":"e_1_3_3_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-024-02319-7"},{"key":"e_1_3_3_125_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-020-01070-z"},{"key":"e_1_3_3_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12954"},{"key":"e_1_3_3_127_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-023-02118-6"},{"key":"e_1_3_3_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lanepe.2023.100617"},{"key":"e_1_3_3_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-71231-7"},{"key":"e_1_3_3_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2025.112086"},{"key":"e_1_3_3_131_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.15809"},{"issue":"4","key":"e_1_3_3_132_1","first-page":"165","article-title":"Comparing medication adherence and persistence among patients with type 2 diabetes using sodium-glucose cotransporter 2 inhibitors or sulfonylureas","volume":"10","author":"Bell KF","year":"2017","unstructured":"Bell KF, Cappell K, Liang M, et al. Comparing medication adherence and persistence among patients with type 2 diabetes using sodium-glucose cotransporter 2 inhibitors or sulfonylureas. Am Heal Drug Benefits. 2017;10(4):165\u2013174.","journal-title":"Am Heal Drug Benefits"},{"key":"e_1_3_3_133_1","doi-asserted-by":"publisher","DOI":"10.1177\/20420188231180987"},{"key":"e_1_3_3_134_1","doi-asserted-by":"publisher","DOI":"10.2196\/50737"},{"key":"e_1_3_3_135_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.830401"},{"key":"e_1_3_3_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metop.2020.100028"},{"key":"e_1_3_3_137_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-019-00743-6"},{"key":"e_1_3_3_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcte.2024.100335"},{"key":"e_1_3_3_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13900"},{"key":"e_1_3_3_140_1","unstructured":"World Health Organisation. Obesity and overweight [Internet]. 2024 [cited 2025 Mar 29]."},{"key":"e_1_3_3_141_1","unstructured":"Oregon State. Pharmacologic agents for weight management: clinical evidence and management strategies [Internet]. 2023. Available from: https:\/\/www.orpdl.org\/durm\/meetings\/meetingdocs\/2024_04_04\/finals\/DERP_WtLossExecSummary.pdf"},{"key":"e_1_3_3_142_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098099"}],"container-title":["Expert Opinion on Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14740338.2025.2573368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T15:57:44Z","timestamp":1772726264000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14740338.2025.2573368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,13]]},"references-count":140,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3,4]]}},"alternative-id":["10.1080\/14740338.2025.2573368"],"URL":"https:\/\/doi.org\/10.1080\/14740338.2025.2573368","relation":{},"ISSN":["1474-0338","1744-764X"],"issn-type":[{"value":"1474-0338","type":"print"},{"value":"1744-764X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,13]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieds20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieds20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-03-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-16","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}