{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:32:39Z","timestamp":1793467959246,"version":"4.5.0"},"reference-count":102,"publisher":"Informa UK Limited","content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Opinion on Drug Safety"],"DOI":"10.1080\/14740338.2025.2574668","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:11:43Z","timestamp":1760368303000},"page":"1-21","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":10,"title":["Hypogammaglobulinemia and infections in patients with multiple sclerosis treated with anti-CD20 monoclonal antibodies: a systematic review and meta-analysis of observational studies"],"prefix":"10.1080","author":[{"given":"Cristina","family":"Scavone","sequence":"first","affiliation":[{"name":"Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]},{"name":"Link Campus University","place":["Rome, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Cagnotta","sequence":"additional","affiliation":[{"name":"Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liberata","family":"Sportiello","sequence":"additional","affiliation":[{"name":"Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia Teresa","family":"Maniscalco","sequence":"additional","affiliation":[{"name":"\u201cA. Cardarelli\u201d Hospital","place":["Naples, Italy"]},{"name":"\u201cA. Cardarelli\u201d Hospital","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Ragone","sequence":"additional","affiliation":[{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]},{"name":"Max Planck Institute of Molecular Physiology","place":["Dortmund, Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Frasca","sequence":"additional","affiliation":[{"name":"Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Capuano","sequence":"additional","affiliation":[{"name":"Campania Regional Centre for Pharmacovigilance and Pharmacoepidemiology","place":["Naples, Italy"]},{"name":"University of Campania \u201cLuigi Vanvitelli\u201d","place":["Naples, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,10,24]]},"reference":[{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-88-470-1711-5_8"},{"issue":"2","key":"e_1_3_5_4_1","first-page":"SS15","article-title":"Overview of the epidemiology, diagnosis, and disease progression associated with multiple sclerosis","volume":"19","author":"Tullman MJ","year":"2013","unstructured":"Tullman MJ. Overview of the epidemiology, diagnosis, and disease progression associated with multiple sclerosis. Am J Manag Care. 2013;19(Suppl. 2):SS15\u2013S20.","journal-title":"Am J Manag Care"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11169-w"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/187152712801661266"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.CON.0000433291.23091.65"},{"key":"e_1_3_5_8_1","unstructured":"Available from: https:\/\/www.mayoclinic.org\/diseases-conditions\/multiple-sclerosis\/diagnosis-treatment\/drc-20350274"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2017.1388371"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph13120466"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-024-02011-w"},{"issue":"3","key":"e_1_3_5_12_1","first-page":"235","article-title":"Targeting CD20 in multiple sclerosis \u2013 review of current treatment strategies","volume":"57","author":"Chmielewska N","year":"2023","unstructured":"Chmielewska N, Szyndler J. Targeting CD20 in multiple sclerosis \u2013 review of current treatment strategies. Neurol Neurochir Pol. 2023;57(3):235\u2013242.","journal-title":"Neurol Neurochir Pol"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1004795"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.102787"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2022.01.025"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.105009"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1380654"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003583"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2288-14-45"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNF.0000000000000612"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.medj.2023.05.001"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/aian.AIAN_167_21"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjno-2020-000108"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.592304"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/2055217320973049"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/2055217316672100"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.104941"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12581-0"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103021"},{"key":"e_1_3_5_30_1","doi-asserted-by":"publisher","DOI":"10.1080\/21556660.2021.1989193"},{"key":"e_1_3_5_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-024-12360-x"},{"key":"e_1_3_5_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2024.105776"},{"key":"e_1_3_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2024.105570"},{"key":"e_1_3_5_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-022-11350-1"},{"key":"e_1_3_5_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.116973"},{"key":"e_1_3_5_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519872889"},{"key":"e_1_3_5_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.105345"},{"key":"e_1_3_5_38_1","doi-asserted-by":"publisher","DOI":"10.1177\/2055217320964505"},{"key":"e_1_3_5_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16331"},{"key":"e_1_3_5_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04434-1"},{"key":"e_1_3_5_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.101468"},{"key":"e_1_3_5_42_1","doi-asserted-by":"publisher","DOI":"10.1080\/00325481.2019.1649975"},{"key":"e_1_3_5_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.104441"},{"key":"e_1_3_5_44_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003331"},{"key":"e_1_3_5_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51282"},{"key":"e_1_3_5_46_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X22666231002142709"},{"key":"e_1_3_5_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25105353"},{"key":"e_1_3_5_48_1","doi-asserted-by":"publisher","DOI":"10.1177\/13524585231175284"},{"key":"e_1_3_5_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103798"},{"key":"e_1_3_5_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-024-02572-3"},{"key":"e_1_3_5_51_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9084759"},{"key":"e_1_3_5_52_1","first-page":"1","article-title":"Hypogammaglobulinemia and infection risk in an ocrelizumab-treated multiple sclerosis cohort","volume":"12","author":"Nobile S","year":"2024","unstructured":"Nobile S, Beauchemin P. Hypogammaglobulinemia and infection risk in an ocrelizumab-treated multiple sclerosis cohort. Can J Neurol Sci. 2024 Feb;12:1\u20138.","journal-title":"Can J Neurol Sci"},{"key":"e_1_3_5_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.13225"},{"key":"e_1_3_5_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16228"},{"key":"e_1_3_5_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.104556"},{"key":"e_1_3_5_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.104218"},{"key":"e_1_3_5_57_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520952036"},{"key":"e_1_3_5_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2023.105028"},{"key":"e_1_3_5_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/ane.12963"},{"key":"e_1_3_5_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11020353"},{"key":"e_1_3_5_61_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000719"},{"key":"e_1_3_5_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197415"},{"key":"e_1_3_5_63_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200211"},{"key":"e_1_3_5_64_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000001115"},{"key":"e_1_3_5_65_1","doi-asserted-by":"publisher","DOI":"10.17712\/nsj.2022.2.20210122"},{"key":"e_1_3_5_66_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200104"},{"key":"e_1_3_5_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0190425"},{"key":"e_1_3_5_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2023.1060696"},{"key":"e_1_3_5_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-021-01104-8"},{"issue":"3","key":"e_1_3_5_70_1","first-page":"103","article-title":"Evaluation of safety of rituximab in patients with multiple sclerosis: a retrograde study","volume":"19","author":"Majdinasab N","year":"2020","unstructured":"Majdinasab N, Sadrian M, Kashipazha D, et al. Evaluation of safety of rituximab in patients with multiple sclerosis: a retrograde study. Curr J Neurol. 2020 Jul 5;19(3):103\u2013106.","journal-title":"Curr J Neurol"},{"key":"e_1_3_5_71_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458520912170"},{"key":"e_1_3_5_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.101980"},{"key":"e_1_3_5_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2019.101419"},{"key":"e_1_3_5_74_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjno-2024-000672"},{"key":"e_1_3_5_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2021.08.003"},{"key":"e_1_3_5_76_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-012-9367-0"},{"key":"e_1_3_5_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-018-0295-0"},{"key":"e_1_3_5_78_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562864231162661"},{"key":"e_1_3_5_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2020.05.049"},{"key":"e_1_3_5_80_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1602972"},{"key":"e_1_3_5_81_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706383"},{"key":"e_1_3_5_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8263-4"},{"key":"e_1_3_5_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-021-00895-w"},{"key":"e_1_3_5_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.102279"},{"key":"e_1_3_5_85_1","volume-title":"StatPearls [Internet]","author":"Huq ME","year":"2023","unstructured":"Huq ME, Bhatnagar NK, Hostoffer RW. Hypogammaglobulinemia. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jun 5. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK563134\/"},{"key":"e_1_3_5_86_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01653"},{"key":"e_1_3_5_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2007.06584.x"},{"key":"e_1_3_5_88_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt-2017-0178"},{"key":"e_1_3_5_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2020.101982"},{"key":"e_1_3_5_90_1","doi-asserted-by":"publisher","DOI":"10.7191\/neurol_bull.2010.1020"},{"key":"e_1_3_5_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01761-3"},{"key":"e_1_3_5_92_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000012700"},{"key":"e_1_3_5_93_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.3365"},{"key":"e_1_3_5_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anai.2023.01.018"},{"key":"e_1_3_5_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2024.106236"},{"key":"e_1_3_5_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2024.106191"},{"key":"e_1_3_5_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2022.100470"},{"key":"e_1_3_5_98_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200164"},{"key":"e_1_3_5_99_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11175104"},{"issue":"3","key":"e_1_3_5_100_1","first-page":"114","article-title":"Adverse drug reactions and gender differences: what changes in drug safety?","volume":"5","author":"di Mauro G","year":"2019","unstructured":"di Mauro G, Zinzi A, Vitiello F, et al. Adverse drug reactions and gender differences: what changes in drug safety? Ital J Gend-Specif Med. 2019;5(3):114\u2013122.","journal-title":"Ital J Gend-Specif Med"},{"key":"e_1_3_5_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines11092538"},{"key":"e_1_3_5_102_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200056"},{"key":"e_1_3_5_103_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2024.1383910"},{"key":"e_1_3_5_104_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2025.2493795"}],"container-title":["Expert Opinion on Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14740338.2025.2574668","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T14:15:02Z","timestamp":1761315302000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14740338.2025.2574668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,24]]},"references-count":102,"alternative-id":["10.1080\/14740338.2025.2574668"],"URL":"https:\/\/doi.org\/10.1080\/14740338.2025.2574668","relation":{},"ISSN":["1474-0338","1744-764X"],"issn-type":[{"value":"1474-0338","type":"print"},{"value":"1744-764X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,24]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieds20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ieds20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2025-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}