{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T21:54:25Z","timestamp":1777672465991,"version":"3.51.4"},"reference-count":48,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["21772131"],"award-info":[{"award-number":["21772131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81872535"],"award-info":[{"award-number":["81872535"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds of Science & Technology Department of Sichuan Province","award":["2019YFSY0004"],"award-info":[{"award-number":["2019YFSY0004"]}]},{"name":"Fundamental Research Funds of Science & Technology Department of Sichuan Province","award":["2017JY0123"],"award-info":[{"award-number":["2017JY0123"]}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2016M602696"],"award-info":[{"award-number":["2016M602696"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"crossref","award":["2016M592694"],"award-info":[{"award-number":["2016M592694"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Fundamental Research Funds for the Central Universities and Distinguished Young Scholars of Sichuan University","award":["2015SCU04A13"],"award-info":[{"award-number":["2015SCU04A13"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1080\/14756366.2019.1596903","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T01:10:51Z","timestamp":1554685851000},"page":"909-926","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":15,"title":["Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90\/phosphoinositide 3-kinase alpha (Hsp90\/PI3K\u03b1) against cutaneous melanoma"],"prefix":"10.1080","volume":"34","author":[{"given":"Feifei","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]},{"name":"Department of Cardiology, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yali","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]},{"name":"Department of Cardiology, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]},{"name":"Department of Cardiology, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujia","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]},{"name":"Department of Cardiology, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]},{"name":"Department of Cardiology, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]},{"name":"Department of Cardiology, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]},{"name":"Department of Cardiology, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinglin","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Sichuan Province College Key Laboratory of Structure-Specific Small Molecule Drugs, Chengdu Medical College","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1536-8882","authenticated-orcid":false,"given":"Gu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Dermatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]},{"name":"Department of Cardiology, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy","place":["Chengdu, China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2019,4,7]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21387"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21442"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21338"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx247"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.044"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep07857"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.052"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(02)00041-4"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.11.023"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.07.018"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.06.057"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.04.052"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.06.032"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.05.033"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.09.043"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.07.080"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.04.074"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003701200"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.3.242"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2017.302"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-3151"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2016.03.076"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143847"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2014.10.040"},{"key":"e_1_3_3_26_1","first-page":"S46","article-title":"Strong radiosensitizing effects by combination of Hsp90 inhibitor NVP-AUY922 and dual PI3 K\/mTOR inhibitor PI-103 on PTEN knock-down tumor cell lines","volume":"191","author":"Hartmann S","year":"2015","unstructured":"Hartmann S, Popov N, Zhu J, et\u00a0al. Strong radiosensitizing effects by combination of Hsp90 inhibitor NVP-AUY922 and dual PI3 K\/mTOR inhibitor PI-103 on PTEN knock-down tumor cell lines. Strahlenther Onkol 2015;191:S46.","journal-title":"Strahlenther Onkol"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.21174"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.1706"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-0538"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1064120"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.02.052"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2004088"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1218485"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1190710"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00275"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.11.009"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/adsc.201400172"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.3987\/COM-13-12828"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8CC04732D"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1039\/C8QO00422F"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.orglett.7b03516"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21398"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CC04968G"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201503063"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4NR02978J"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.102"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2014.01.003"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12451"}],"container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14756366.2019.1596903","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:05:03Z","timestamp":1777449903000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14756366.2019.1596903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":48,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,1]]}},"alternative-id":["10.1080\/14756366.2019.1596903"],"URL":"https:\/\/doi.org\/10.1080\/14756366.2019.1596903","relation":{},"ISSN":["1475-6366","1475-6374"],"issn-type":[{"value":"1475-6366","type":"print"},{"value":"1475-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2018-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}