{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:43:20Z","timestamp":1793123000216,"version":"4.5.0"},"reference-count":84,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Conselho Nacional Cient\u00edfico e Tecnol\u00f3gico"},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100006418","name":"Brown University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100006418","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1080\/14756366.2019.1616182","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T05:08:30Z","timestamp":1558674510000},"page":"1100-1109","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":55,"title":["<i>Leishmania infantum<\/i>\n                    arginase: biochemical characterization and inhibition by naturally occurring phenolic substances"],"prefix":"10.1080","volume":"34","author":[{"given":"Andreza R.","family":"Garcia","sequence":"first","affiliation":[{"name":"Graduate Program in Pharmaceutical Sciences, School of Pharmacy, Federal University of Rio de Janeiro","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle M. P.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2532-471X","authenticated-orcid":false,"given":"Ana","family":"Claudia F. Amaral","sequence":"additional","affiliation":[{"name":"Department of Natural Products, Farmanguinhos, FIOCRUZ","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9ssica B.","family":"Jesus","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines, School of Pharmacy, Federal University of Rio de Janeiro","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"Renn\u00f3 Sodero","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines, School of Pharmacy, Federal University of Rio de Janeiro","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra M. T.","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines, School of Pharmacy, Federal University of Rio de Janeiro","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Neurofarba Department, Universit\u00e0 degli Studi di Firenze, Sezione di Scienze Farmaceutiche","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5926-4172","authenticated-orcid":false,"given":"Alane B.","family":"Vermelho","sequence":"additional","affiliation":[{"name":"Department of General Microbiology, Institute of Microbiology Paulo de Goes, Federal University of Rio de Janeiro","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9432-3991","authenticated-orcid":false,"given":"Igor A.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Graduate Program in Pharmaceutical Sciences, School of Pharmacy, Federal University of Rio de Janeiro","place":["Rio de Janeiro, Brazil"]},{"name":"Department of Natural Products and Food, School of Pharmacy, Federal University of Rio de Janeiro","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5118-6931","authenticated-orcid":false,"given":"Anderson S.","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Institute of Chemistry, Federal University of Rio de Janeiro","place":["Rio de Janeiro, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"e_1_3_2_2_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.11120.1"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0035671"},{"key":"e_1_3_2_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005150"},{"key":"e_1_3_2_5_1","unstructured":"World Health Organization (WHO). Global Health Observatory (GHO) data. Leishmaniasis: Situation and trends. Available from https:\/\/www.who.int\/gho\/neglected_diseases\/leishmaniasis\/en\/. [last accessed 23 Feb 2019]."},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182016002523"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ar040183k"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00291.x"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M402042200"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006026"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-010-0630-3"},{"key":"e_1_3_2_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpara.2010.12.006"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exppara.2012.01.015"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2013.01.014"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078387"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.05.025"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/np400717m"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12566"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jnatprod.5b00875"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2018.10.032"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1080\/20477724.2017.1312777"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pep.2006.06.024"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkr981"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.17.3389"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2011.75"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1993.1626"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889892009944"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2013.03.015"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-006-0126-y"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-010-2091-8"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1993.1449"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4683"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2700697"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2007.04.036"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.50.4.1352-1364.2006"},{"key":"e_1_3_2_38_1","first-page":"647","article-title":"Investigation of mammal arginase inhibitory properties of natural ubiquitous polyphenols by using an optimized colorimetric microplate assay","volume":"83","author":"Bordage S","year":"2017","unstructured":"Bordage S, Pham TN, Zedet A, et\u00a0al. Investigation of mammal arginase inhibitory properties of natural ubiquitous polyphenols by using an optimized colorimetric microplate assay. Planta Med 2017;83:647\u201353.","journal-title":"Planta Med"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.193.6.777"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-3416fje"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/134.10.2760S"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddtec.2004.11.007"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-014-3954-1"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.10.031"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2015.1120320"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2015.10.009"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-1659-6"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.02.047"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtb.2017.01.022"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901137j"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-2596"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160115"},{"key":"e_1_3_2_52_2","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2017.1253677"},{"key":"e_1_3_2_52_3","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_3_2_52_4","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3554"},{"key":"e_1_3_2_52_5","doi-asserted-by":"publisher","DOI":"10.2174\/1568016043477305"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2014.910202"},{"key":"e_1_3_2_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.08.015"},{"key":"e_1_3_2_53_3","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.672983"},{"key":"e_1_3_2_53_4","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1059333"},{"key":"e_1_3_2_53_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2003.12.029"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0223-5234(97)86179-X"},{"key":"e_1_3_2_54_2","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1519023"},{"key":"e_1_3_2_54_3","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1523897"},{"key":"e_1_3_2_54_4","doi-asserted-by":"publisher","DOI":"10.1021\/jm060807n"},{"key":"e_1_3_2_54_5","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.13.10.1545"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600830603"},{"key":"e_1_3_2_55_2","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1122001"},{"key":"e_1_3_2_55_3","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1235042"},{"key":"e_1_3_2_55_4","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1243536"},{"key":"e_1_3_2_55_5","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1244533"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1135914"},{"key":"e_1_3_2_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.10.018"},{"key":"e_1_3_2_56_3","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21121649"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm400939k"},{"key":"e_1_3_2_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.06.050"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2015.1067685"},{"key":"e_1_3_2_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.10.006"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.01.034"},{"key":"e_1_3_2_59_2","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1414808"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180326160121"},{"key":"e_1_3_2_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.04.010"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1463221"},{"key":"e_1_3_2_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2019.01.069"},{"key":"e_1_3_2_61_3","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00430"}],"container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/tandfonline.com\/doi\/pdf\/10.1080\/14756366.2019.1616182","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14756366.2019.1616182","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:13:08Z","timestamp":1777450388000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14756366.2019.1616182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":84,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,1]]}},"alternative-id":["10.1080\/14756366.2019.1616182"],"URL":"https:\/\/doi.org\/10.1080\/14756366.2019.1616182","relation":{},"ISSN":["1475-6366","1475-6374"],"issn-type":[{"value":"1475-6366","type":"print"},{"value":"1475-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-03-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}