{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T13:13:07Z","timestamp":1793106787547,"version":"4.5.0"},"reference-count":60,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1080\/14756366.2019.1654470","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T02:04:27Z","timestamp":1566353067000},"page":"1526-1533","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":15,"title":["Exploring new structural features of the 4-[(3-methyl-4-aryl-2,3-dihydro-1,3-thiazol-2-ylidene)amino]benzenesulphonamide scaffold for the inhibition of human carbonic anhydrases"],"prefix":"10.1080","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1620-6225","authenticated-orcid":false,"given":"Simona","family":"Distinto","sequence":"first","affiliation":[{"name":"Department of Life and Environmental Sciences, University of Cagliari","place":["Cagliari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1629-7454","authenticated-orcid":false,"given":"Rita","family":"Meleddu","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, University of Cagliari","place":["Cagliari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6235-8161","authenticated-orcid":false,"given":"Francesco","family":"Ortuso","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute, Universit\u00e0 Magna Graecia di Catanzaro","place":["Catanzaro, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Cottiglia","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, University of Cagliari","place":["Cagliari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serenella","family":"Deplano","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, University of Cagliari","place":["Cagliari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5801-9455","authenticated-orcid":false,"given":"Lisa","family":"Sequeira","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, University of Cagliari","place":["Cagliari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Melis","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, University of Cagliari","place":["Cagliari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedetta","family":"Fois","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, University of Cagliari","place":["Cagliari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-7192","authenticated-orcid":false,"given":"Andrea","family":"Angeli","sequence":"additional","affiliation":[{"name":"Dipartimento NEUROFARBA, Sezione di Scienze Farmaceutiche, Universit\u00e0 degli Studi di Firenze","place":["Sesto Fiorentino, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3314-2411","authenticated-orcid":false,"given":"Clemente","family":"Capasso","sequence":"additional","affiliation":[{"name":"Istituto di Bioscienze e Biorisorse, CNR","place":["Napoli, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Angius","sequence":"additional","affiliation":[{"name":"Laboratorio NMR e Tecnologie Bioanalitiche","place":["Pula, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0437-358X","authenticated-orcid":false,"given":"Stefano","family":"Alcaro","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute, Universit\u00e0 Magna Graecia di Catanzaro","place":["Catanzaro, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Dipartimento NEUROFARBA, Sezione di Scienze Farmaceutiche, Universit\u00e0 degli Studi di Firenze","place":["Sesto Fiorentino, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2175-2802","authenticated-orcid":false,"given":"Elias","family":"Maccioni","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, University of Cagliari","place":["Cagliari, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,8,20]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01267a514"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)91118-6"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.07.073"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr980449z"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.5530080303"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.42.1768"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.7.2484"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1238366"},{"key":"e_1_3_3_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.02.032"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147225"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612811319100009"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.01.056"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1113171"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.51.275"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/np0106283"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2012000800011"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm800132g"},{"key":"e_1_3_3_19_1","first-page":"122","article-title":"Treatment of vaginal trichomoniasis with aminitrozole and trichomycin given orally","volume":"149","author":"Willcox RR","year":"1960","unstructured":"Willcox RR. Treatment of vaginal trichomoniasis with aminitrozole and trichomycin given orally. Gynaecologia 1960;149:122\u20137.","journal-title":"Gynaecologia"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805353200"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2009.10.021"},{"key":"e_1_3_3_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.2000.80.2.681"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.08.107"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160115"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1862"},{"key":"e_1_3_3_26_1","doi-asserted-by":"publisher","DOI":"10.4149\/neo_2015_054"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.04.044"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.5306\/wjco.v3.i7.98"},{"key":"e_1_3_3_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3554"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-007-9064-0"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2014-0054OC"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.05.076"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.01.030"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2014.942659"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.672983"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.13.10.1545"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2000.84"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901287j"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja809683v"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1122001"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460441.2013.795145"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200176r"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/ml500196t"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.06.003"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5OB00688K"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.09.021"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1235042"},{"key":"e_1_3_3_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.7b00205"},{"key":"e_1_3_3_50_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00352"},{"key":"e_1_3_3_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00170"},{"key":"e_1_3_3_52_1","unstructured":"Schr\u00f6dinger LLC New York NY. 2018."},{"key":"e_1_3_3_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540110405"},{"key":"e_1_3_3_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20222"},{"key":"e_1_3_3_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci900231p"},{"key":"e_1_3_3_56_1","first-page":"1986","volume-title":"Encyclopedia of Computational Chemistry","author":"Jorgensen WL","year":"1998","unstructured":"Jorgensen WL. OPLS force fields. In Schleyer PvR, ed. Encyclopedia of Computational Chemistry. New York: Wiley; 1998:1986\u20139."},{"key":"e_1_3_3_57_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.750311"},{"key":"e_1_3_3_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)95800-X"},{"key":"e_1_3_3_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_3_3_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2011.01104.x"},{"key":"e_1_3_3_61_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.8b00596"}],"container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14756366.2019.1654470","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T08:11:14Z","timestamp":1777450274000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14756366.2019.1654470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,1]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1,1]]}},"alternative-id":["10.1080\/14756366.2019.1654470"],"URL":"https:\/\/doi.org\/10.1080\/14756366.2019.1654470","relation":{},"ISSN":["1475-6366","1475-6374"],"issn-type":[{"value":"1475-6366","type":"print"},{"value":"1475-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,1]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-05","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}