{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T22:44:04Z","timestamp":1783723444762,"version":"3.55.0"},"reference-count":78,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2019,10,16]],"date-time":"2019-10-16T00:00:00Z","timestamp":1571184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"published-print":{"date-parts":[[2020,1,1]]},"DOI":"10.1080\/14756366.2019.1677638","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T04:51:40Z","timestamp":1571287900000},"page":"21-30","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":23,"title":["A structure-based approach towards the identification of novel antichagasic compounds: <i>Trypanosoma cruzi<\/i> carbonic anhydrase inhibitors"],"prefix":"10.1080","volume":"35","author":[{"given":"Manuel A.","family":"Llanos","sequence":"first","affiliation":[{"name":"Laboratory of Bioactive Research and Development (LIDeB), Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda L.","family":"Sbaraglini","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Research and Development (LIDeB), Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda L.","family":"Villalba","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Research and Development (LIDeB), Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda D.","family":"Ruiz","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias y Tecnolog\u00eda Dr. Cesar Milstein (ICT Milstein), Argentinean National Council of Scientific and Technical Research (CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Carrillo","sequence":"additional","affiliation":[{"name":"Instituto de Ciencias y Tecnolog\u00eda Dr. Cesar Milstein (ICT Milstein), Argentinean National Council of Scientific and Technical Research (CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalina","family":"Alba Soto","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda, Parasitolog\u00eda e Inmunolog\u00eda, Facultad de Medicina, Universidad de Buenos Aires, Instituto de Investigaciones en Microbiolog\u00eda y Parasitolog\u00eda M\u00e9dica (IMPaM), UBA-CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Talevi","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Research and Development (LIDeB), Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1470-7192","authenticated-orcid":false,"given":"Andrea","family":"Angeli","sequence":"additional","affiliation":[{"name":"Neurofarba Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Universita degli Studi di Firenze, Sesto Fiorentino, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seppo","family":"Parkkila","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Technology, University of Tampere, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Neurofarba Department, Sezione di Scienze Farmaceutiche e Nutraceutiche, Universita degli Studi di Firenze, Sesto Fiorentino, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Gavernet","sequence":"additional","affiliation":[{"name":"Laboratory of Bioactive Research and Development (LIDeB), Medicinal Chemistry, Department of Biological Sciences, Faculty of Exact Sciences, National University of La Plata, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2019,10,16]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1021\/cr200176r"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1519023"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1523897"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2018.1548608"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1508453"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M805353200"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2017-0223"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2011.11.017"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.3390\/metabo7030048"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.3390\/metabo8020025"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1428572"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-7359-2_15"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/S0223-5234(97)86179-X"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1122001"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2017.1253677"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160115"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3554"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.2174\/1568016043477305"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.15.185"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02761909000200008"},{"key":"CIT0022","first-page":"v","volume":"975","author":"World Health Organization","year":"2012","journal-title":"World Health Organ Tech Rep Ser"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23010"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1021\/jm4000616"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.2013.778245"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2014.991312"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2015.1067685"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2018.1497161"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.3390\/metabo7040056"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1021\/jm400418p"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004343"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki408"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1099"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0059004"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1002\/pro.2389"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1115898108"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.11.008"},{"key":"CIT0038","volume-title":"AMBER 2018","author":"Case DA","year":"2018"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1021\/ct1002626"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1414808"},{"key":"CIT0041","unstructured":"Sketch M. 2014. Available from: http:\/\/www.chemaxon.com\/products\/marvin\/marvinsketch\/"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1021\/ci500209e"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21256"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1021\/jm800764p"},{"key":"CIT0045","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.05.024"},{"key":"CIT0046","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.02.001"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.01.012"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01470"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)62326-9"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1021\/jm050333c"},{"key":"CIT0051","first-page":"77:542","author":"Lolak N","year":"2018","journal-title":"Bioorg Chem"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1515933"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1021\/jm060807n"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1517\/13543776.13.10.1545"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1080\/14756360127571"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2003.12.029"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1235042"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1243536"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1244533"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.04.056"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1463221"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1386660"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2015.1066675"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1111\/j.1747-0285.2011.01104.x"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1367775"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1337759"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1333987"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2016.1154534"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2011.597749"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(99)00190-X"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1355306"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2017.1356295"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/279618"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1016\/j.actatropica.2015.08.004"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.235"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1993.1626"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1021\/jm049092j"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2496(75)90001-2"}],"container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14756366.2019.1677638","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T13:06:14Z","timestamp":1626181574000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14756366.2019.1677638"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,16]]},"references-count":78,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1,1]]}},"alternative-id":["10.1080\/14756366.2019.1677638"],"URL":"https:\/\/doi.org\/10.1080\/14756366.2019.1677638","relation":{},"ISSN":["1475-6366","1475-6374"],"issn-type":[{"value":"1475-6366","type":"print"},{"value":"1475-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,16]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2019-09-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}