{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:17:12Z","timestamp":1791256632427,"version":"4.1.0"},"reference-count":41,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Korea Government","doi-asserted-by":"publisher","award":["CAP-20-01-KRIBB"],"award-info":[{"award-number":["CAP-20-01-KRIBB"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011040","name":"Korea Research Fellowship Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011040","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT","doi-asserted-by":"crossref","award":["2019H1D3A1A0107088214"],"award-info":[{"award-number":["2019H1D3A1A0107088214"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003693","name":"Korea Institute of Science and Technology","doi-asserted-by":"publisher","award":["2E31512"],"award-info":[{"award-number":["2E31512"]}],"id":[{"id":"10.13039\/501100003693","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"published-print":{"date-parts":[[2023,12,31]]},"DOI":"10.1080\/14756366.2022.2154603","type":"journal-article","created":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T09:54:18Z","timestamp":1675331658000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":18,"title":["Discovery of new 6-ureido\/amidocoumarins as highly potent and selective inhibitors for the tumour-relevant carbonic anhydrases IX and XII"],"prefix":"10.1080","volume":"38","author":[{"given":"Ashraf K.","family":"El-Damasy","sequence":"first","affiliation":[{"name":"Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST)","place":["Seoul, South Korea"]},{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University","place":["Mansoura, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Ji","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST)","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3342-702X","authenticated-orcid":false,"given":"Alessio","family":"Nocentini","sequence":"additional","affiliation":[{"name":"Section of Pharmaceutical and Nutraceutical Sciences, Department of NEUROFARBA, University of Florence","place":["Florence, Italy"]},{"name":"Laboratory of Molecular Modeling Cheminformatics & QSAR, Department of NEUROFARBA-Pharmaceutical and Nutraceutical Section, University of Firenze","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seon Hee","family":"Seo","sequence":"additional","affiliation":[{"name":"Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST)","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6996-4017","authenticated-orcid":false,"given":"Wagdy M.","family":"Eldehna","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University","place":["Kafr El Sheikh, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Kyoung","family":"Bang","sequence":"additional","affiliation":[{"name":"Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST)","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Section of Pharmaceutical and Nutraceutical Sciences, Department of NEUROFARBA, University of Florence","place":["Florence, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gyochang","family":"Keum","sequence":"additional","affiliation":[{"name":"Center for Brain Technology, Brain Science Institute, Korea Institute of Science and Technology (KIST)","place":["Seoul, South Korea"]},{"name":"Division of Bio-Medical Science & Technology, KIST School, Korea University of Science and Technology (UST)","place":["Seoul, South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,2,2]]},"reference":[{"key":"e_1_3_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2467"},{"key":"e_1_3_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3554"},{"key":"e_1_3_1_4_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5OB00430F"},{"key":"e_1_3_1_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.672983"},{"key":"e_1_3_1_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501497m"},{"key":"e_1_3_1_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b02090"},{"key":"e_1_3_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.05.009"},{"key":"e_1_3_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.10025"},{"key":"e_1_3_1_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr200176r"},{"key":"e_1_3_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21497"},{"key":"e_1_3_1_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-18-0533"},{"key":"e_1_3_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2006.09.002"},{"key":"e_1_3_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20112"},{"key":"e_1_3_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.04.027"},{"key":"e_1_3_1_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00282"},{"key":"e_1_3_1_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1115401"},{"key":"e_1_3_1_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111698"},{"key":"e_1_3_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.10.068"},{"key":"e_1_3_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113283"},{"key":"e_1_3_1_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm101541x"},{"key":"e_1_3_1_22_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4261"},{"key":"e_1_3_1_23_1","unstructured":"[cited 2022 Oct 10]. Available from: https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03450018"},{"key":"e_1_3_1_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0000000000000691"},{"key":"e_1_3_1_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja809683v"},{"key":"e_1_3_1_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.10.094"},{"key":"e_1_3_1_27_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2015.1122001"},{"key":"e_1_3_1_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm501314c"},{"key":"e_1_3_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.09.041"},{"key":"e_1_3_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112897"},{"key":"e_1_3_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2018.10.005"},{"key":"e_1_3_1_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2017.03.027"},{"key":"e_1_3_1_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2019.03.001"},{"key":"e_1_3_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0223-5234(98)80033-0"},{"key":"e_1_3_1_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112745"},{"key":"e_1_3_1_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.114008"},{"key":"e_1_3_1_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202000915"},{"key":"e_1_3_1_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.113035"},{"key":"e_1_3_1_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/00397911.2020.1792498"},{"key":"e_1_3_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201700446"},{"key":"e_1_3_1_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.112019"},{"key":"e_1_3_1_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.07.025"}],"container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14756366.2022.2154603","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T05:49:53Z","timestamp":1764481793000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14756366.2022.2154603"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,2]]},"references-count":41,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,12,31]]}},"alternative-id":["10.1080\/14756366.2022.2154603"],"URL":"https:\/\/doi.org\/10.1080\/14756366.2022.2154603","relation":{},"ISSN":["1475-6366","1475-6374"],"issn-type":[{"value":"1475-6366","type":"print"},{"value":"1475-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2022-10-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-30","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2154603"}}