{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T21:17:00Z","timestamp":1793308620818,"version":"4.5.0"},"reference-count":67,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2023,7,11]],"date-time":"2023-07-11T00:00:00Z","timestamp":1689033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003009","name":"Science, Technology & Innovation Funding Authority","doi-asserted-by":"crossref","award":["44025"],"award-info":[{"award-number":["44025"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003009","name":"Science, Technology & Innovation Funding Authority","doi-asserted-by":"crossref","award":["."],"award-info":[{"award-number":["."]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"published-print":{"date-parts":[[2023,12,31]]},"DOI":"10.1080\/14756366.2023.2234665","type":"journal-article","created":{"date-parts":[[2023,7,12]],"date-time":"2023-07-12T02:08:01Z","timestamp":1689127681000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":30,"title":["Identification of sulphonamide-tethered\n                    <i>N<\/i>\n                    -((triazol-4-yl)methyl)isatin derivatives as inhibitors of SARS-CoV-2 main protease"],"prefix":"10.1080","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5481-2053","authenticated-orcid":false,"given":"Mai H.","family":"ElNaggar","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University","place":["Kafrelsheikh, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5851-3306","authenticated-orcid":false,"given":"Abdullah A.","family":"Elgazar","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University","place":["Kafrelsheikh, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghada","family":"Gamal","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University","place":["Kafrelsheikh, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimaa M.","family":"Hamed","sequence":"additional","affiliation":[{"name":"Scientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University","place":["Kafrelsheikh, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zainab M.","family":"Elsayed","sequence":"additional","affiliation":[{"name":"Scientific Research and Innovation Support Unit, Faculty of Pharmacy, Kafrelsheikh University","place":["Kafrelsheikh, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed K.","family":"El-Ashrey","sequence":"additional","affiliation":[{"name":"Pharmaceutical Chemistry Department, Faculty of Pharmacy, Cairo University","place":["Cairo, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amira","family":"Abood","sequence":"additional","affiliation":[{"name":"Chemistry of Natural and microbial products, National Research center","place":["Egypt"]},{"name":"Department of Bioscience, University of Kent","place":["Canterbury, UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud A.","family":"El Hassab","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, Faculty of Pharmacy, King Salman International University (KSIU)","place":["Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Pharmacy, Kafrelsheikh University","place":["Kafrelsheikh, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramadan A.","family":"El-Domany","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Faculty of Pharmacy, Kafrelsheikh University","place":["Kafrelsheikh, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farid A.","family":"Badria","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University","place":["Mansoura, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4262-0323","authenticated-orcid":false,"given":"Claudiu T.","family":"Supuran","sequence":"additional","affiliation":[{"name":"Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence","place":["Firenze, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6996-4017","authenticated-orcid":false,"given":"Wagdy M.","family":"Eldehna","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University","place":["Kafrelsheikh, Egypt"]},{"name":"School of Biotechnology, Badr University in Cairo","place":["Badr City, Egypt"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,7,11]]},"reference":[{"key":"e_1_3_2_2_1","first-page":"157","article-title":"WHO declares COVID-19 a pandemic","volume":"91","author":"Cucinotta D","year":"2020","unstructured":"Cucinotta D, Vanelli M. WHO declares COVID-19 a pandemic. Acta Biomed. 2020;91:157\u2013160.","journal-title":"Acta Biomed"},{"key":"e_1_3_2_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2020.1760838"},{"key":"e_1_3_2_4_1","unstructured":"CDC. COVID-19 Treatments and Medications. 2023. https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/your-health\/treatments-for-severe-illness.html"},{"key":"e_1_3_2_5_1","unstructured":"CDC. Interim Clinical Considerations for COVID-19 Treatment in Outpatients. 2023. https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/hcp\/clinical-care\/outpatient-treatment-overview.html"},{"key":"e_1_3_2_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2021.1901402"},{"key":"e_1_3_2_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2021.1924165"},{"key":"e_1_3_2_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010259"},{"key":"e_1_3_2_9_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002271"},{"key":"e_1_3_2_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2223-y"},{"key":"e_1_3_2_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02612-07"},{"issue":"6","key":"e_1_3_2_12_1","first-page":"547","article-title":"Protease inhibitors targeting the main protease and papain-like protease of coronaviruses","volume":"17","author":"Capasso C","year":"2022","unstructured":"a) Capasso C, Nocentini A, Supuran CT. Protease inhibitors targeting the main protease and papain-like protease of coronaviruses. Expert Opin Drug Discov. 2022;17(6):547\u2013557. b) Nocentini A, Capasso C, Supuran CT. Perspectives on the design and discovery of \u03b1-ketoamide inhibitors for the treatment of novel coronavirus: where do we stand and where do we go? Expert Opin Drug Discov. 202;(6)547\u2013557.","journal-title":"Expert Opin Drug Discov"},{"key":"e_1_3_2_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0356-z"},{"key":"e_1_3_2_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-022-02951-6"},{"key":"e_1_3_2_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.05.005"},{"key":"e_1_3_2_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.113102"},{"key":"e_1_3_2_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.104748"},{"key":"e_1_3_2_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2018.1462802"},{"key":"e_1_3_2_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2022.2085693"},{"key":"e_1_3_2_20_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2020.1773814"},{"key":"e_1_3_2_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.12.017"},{"key":"e_1_3_2_22_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2RA04385H"},{"key":"e_1_3_2_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2016.07.032"},{"key":"e_1_3_2_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27248807"},{"key":"e_1_3_2_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2020.1868450"},{"key":"e_1_3_2_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2005.02.037"},{"key":"e_1_3_2_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.06.042"},{"key":"e_1_3_2_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.104816"},{"key":"e_1_3_2_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114959"},{"key":"e_1_3_2_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-021-02832-4"},{"key":"e_1_3_2_31_1","doi-asserted-by":"publisher","DOI":"10.1159\/000007182"},{"key":"e_1_3_2_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.10.020"},{"key":"e_1_3_2_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.07.046"},{"key":"e_1_3_2_34_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557518666180424093305"},{"key":"e_1_3_2_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep20122"},{"key":"e_1_3_2_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.02.037"},{"key":"e_1_3_2_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb400775z"},{"key":"e_1_3_2_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm049147h"},{"key":"e_1_3_2_39_1","doi-asserted-by":"publisher","DOI":"10.1177\/095632020601700504"},{"key":"e_1_3_2_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.11.028"},{"key":"e_1_3_2_41_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.40339"},{"key":"e_1_3_2_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2005.04.027"},{"key":"e_1_3_2_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0602357"},{"key":"e_1_3_2_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112702"},{"key":"e_1_3_2_45_1","doi-asserted-by":"publisher","DOI":"10.3390\/md20030179"},{"key":"e_1_3_2_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2021.05.018"},{"key":"e_1_3_2_47_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2021.1988944"},{"key":"e_1_3_2_48_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2023.2166036"},{"key":"e_1_3_2_49_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2023.2166037"},{"key":"e_1_3_2_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2021.113360"},{"key":"e_1_3_2_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2020.104347"},{"key":"e_1_3_2_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.4381"},{"key":"e_1_3_2_53_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2020.1809388"},{"key":"e_1_3_2_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11696-021-01697-6"},{"key":"e_1_3_2_55_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3ob41415a"},{"key":"e_1_3_2_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"e_1_3_2_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo12111109"},{"key":"e_1_3_2_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2023.2202357"},{"key":"e_1_3_2_59_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA05268C"},{"key":"e_1_3_2_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012235"},{"key":"e_1_3_2_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"e_1_3_2_62_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01146"},{"key":"e_1_3_2_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.softx.2015.06.001"},{"key":"e_1_3_2_64_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0907444904011679"},{"key":"e_1_3_2_65_1","doi-asserted-by":"publisher","DOI":"10.3390\/pr9061004"},{"key":"e_1_3_2_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2020.584894"},{"key":"e_1_3_2_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2021.1885396"},{"key":"e_1_3_2_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1RA01809D"}],"container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14756366.2023.2234665","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T05:45:19Z","timestamp":1764481519000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14756366.2023.2234665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,11]]},"references-count":67,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,12,31]]}},"alternative-id":["10.1080\/14756366.2023.2234665"],"URL":"https:\/\/doi.org\/10.1080\/14756366.2023.2234665","relation":{},"ISSN":["1475-6366","1475-6374"],"issn-type":[{"value":"1475-6366","type":"print"},{"value":"1475-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,11]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-09","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2234665"}}