{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T10:07:15Z","timestamp":1759399635946,"version":"3.41.2"},"reference-count":22,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Education, Youth and Sports of the Czech Republic through the e-INFRA CZ","award":["90254"],"award-info":[{"award-number":["90254"]}]},{"name":"CZ-OPENSCREEN","award":["LM2023052"],"award-info":[{"award-number":["LM2023052"]}]},{"name":"EATRIS-CZ","award":["LM2023053"],"award-info":[{"award-number":["LM2023053"]}]},{"name":"National Institute for Cancer Research"},{"name":"EXCELES","award":["LX22NPO5102","IGA_LF_2024_038"],"award-info":[{"award-number":["LX22NPO5102","IGA_LF_2024_038"]}]},{"DOI":"10.13039\/501100016367","name":"UCT Prague","doi-asserted-by":"crossref","award":["A1_FPBT_2023_003"],"award-info":[{"award-number":["A1_FPBT_2023_003"]}],"id":[{"id":"10.13039\/501100016367","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"published-print":{"date-parts":[[2024,12,31]]},"DOI":"10.1080\/14756366.2024.2367139","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T09:33:50Z","timestamp":1718962430000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":3,"title":["Click estradiol dimers with novel aromatic bridging units: synthesis and anticancer evaluation"],"prefix":"10.1080","volume":"39","author":[{"given":"Ji\u0159\u00ed","family":"\u0158ehulka","sequence":"first","affiliation":[{"name":"Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palack\u00fd University, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Jur\u00e1\u0161ek","sequence":"additional","affiliation":[{"name":"Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Praha 6, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Dr\u00e1ber","sequence":"additional","affiliation":[{"name":"Department of Biology of Cytoskeleton, Institute of Molecular Genetics of the Czech Academy of Sciences, Praha 4, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandra","family":"Ivanov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palack\u00fd University, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So\u0148a","family":"Gursk\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palack\u00fd University, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate\u0159ina","family":"Je\u010dme\u0148ov\u00e1","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palack\u00fd University, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olena","family":"Mokshyna","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palack\u00fd University, Olomouc, Czech Republic"},{"name":"Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Praha 6, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari\u00e1n","family":"Hajd\u00fach","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palack\u00fd University, Olomouc, Czech Republic"},{"name":"Laboratory of Experimental Medicine, Institute of Molecular and Translational Medicine, University Hospital Olomouc, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel","family":"Polishchuk","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palack\u00fd University, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pavel B.","family":"Dra\u0161ar","sequence":"additional","affiliation":[{"name":"Department of Chemistry of Natural Compounds, University of Chemistry and Technology Prague, Praha 6, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petr","family":"D\u017eub\u00e1k","sequence":"additional","affiliation":[{"name":"Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palack\u00fd University, Olomouc, Czech Republic"},{"name":"Laboratory of Experimental Medicine, Institute of Molecular and Translational Medicine, University Hospital Olomouc, Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"301","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-018-0009-y"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.969183"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114655"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcb.2020.151075"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13225650"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp100190f"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/1933719114537716"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2020.108736"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2018.05.008"},{"key":"e_1_3_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2022.106334"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13321-021-00548-6"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja051685b"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1561269"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11172-016-1334-y"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1993.1626"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.20084"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.21334"},{"key":"e_1_3_5_19_1","unstructured":"Landrum G. RDkit: open-source cheminformatics software; 2021. Available from: https:\/\/www.rdkit.org"},{"key":"e_1_3_5_20_1","unstructured":"Cxcalc utility was used for ligand protonation Cxcalc version 19.22.0. ChemAxon. Available from: https:\/\/www.chemaxon.com"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ct700301q"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.22711"},{"key":"e_1_3_5_23_1","volume-title":"Amber 2023","author":"Case DA","year":"2023","unstructured":"Case DA, Aktulga HM, Belfon K, Ben-Shalom IY, Berryman JT, Brozell SR, Cerutti DS, Cheatham TE, III, Cisneros GA, Cruzeiro VWD, et\u00a0al. Amber 2023. San Francisco: University of California; 2023."}],"container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14756366.2024.2367139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T09:36:05Z","timestamp":1735205765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14756366.2024.2367139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,21]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12,31]]}},"alternative-id":["10.1080\/14756366.2024.2367139"],"URL":"https:\/\/doi.org\/10.1080\/14756366.2024.2367139","relation":{},"ISSN":["1475-6366","1475-6374"],"issn-type":[{"type":"print","value":"1475-6366"},{"type":"electronic","value":"1475-6374"}],"subject":[],"published":{"date-parts":[[2024,6,21]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-11-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-31","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-06","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2367139"}}