{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T02:03:56Z","timestamp":1780020236445,"version":"3.53.1"},"reference-count":28,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T00:00:00Z","timestamp":1779926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["22271136, 22471117"],"award-info":[{"award-number":["22271136, 22471117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["22401138"],"award-info":[{"award-number":["22401138"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis","award":["ZDSYS20190902093215877"],"award-info":[{"award-number":["ZDSYS20190902093215877"]}]},{"DOI":"10.13039\/501100021174","name":"Guangdong Provincial Key Laboratory of Catalysis","doi-asserted-by":"crossref","award":["No. 2020B121201002"],"award-info":[{"award-number":["No. 2020B121201002"]}],"id":[{"id":"10.13039\/501100021174","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Guangdong Innovative Program","award":["No. 2019BT02Y335"],"award-info":[{"award-number":["No. 2019BT02Y335"]}]},{"name":"the Key Supported Project of SUSTech Guangming Advanced Research Institute","award":["K25996901"],"award-info":[{"award-number":["K25996901"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"published-print":{"date-parts":[[2026,12,31]]},"DOI":"10.1080\/14756366.2026.2659998","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T01:47:01Z","timestamp":1780019221000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Discovery of azaindole\/indole-fused pyrimidine tetracyclic scaffolds as novel potent CDK7 inhibitors"],"prefix":"10.1080","volume":"41","author":[{"given":"Fan","family":"Pu","sequence":"first","affiliation":[{"name":"Department of Chemistry and Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis and Guangming Advanced Research Institute, Southern University of Science and Technology","place":["Shenzhen, People\u2019s Republic of China"]},{"name":"Department of Chemistry, The University of Hong Kong","place":["Hong Kong, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Axiao","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis and Guangming Advanced Research Institute, Southern University of Science and Technology","place":["Shenzhen, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengxiang","family":"Qiu","sequence":"additional","affiliation":[{"name":"School of Medicine, Southern University of Science and Technology","place":["Shenzhen, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weishan","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis and Guangming Advanced Research Institute, Southern University of Science and Technology","place":["Shenzhen, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis and Guangming Advanced Research Institute, Southern University of Science and Technology","place":["Shenzhen, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis and Guangming Advanced Research Institute, Southern University of Science and Technology","place":["Shenzhen, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunjiao","family":"He","sequence":"additional","affiliation":[{"name":"School of Medicine, Southern University of Science and Technology","place":["Shenzhen, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng George","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medicine, Southern University of Science and Technology","place":["Shenzhen, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis and Guangming Advanced Research Institute, Southern University of Science and Technology","place":["Shenzhen, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengqing","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis and Guangming Advanced Research Institute, Southern University of Science and Technology","place":["Shenzhen, People\u2019s Republic of China"]},{"name":"SUSTech Academy for Advanced Interdisciplinary Studies","place":["Shenzhen, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuechen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Chemistry, The University of Hong Kong","place":["Hong Kong, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Chemistry and Shenzhen Grubbs Institute and Guangdong Provincial Key Laboratory of Catalysis and Shenzhen Key Laboratory of Small Molecule Drug Discovery and Synthesis and Guangming Advanced Research Institute, Southern University of Science and Technology","place":["Shenzhen, People\u2019s Republic of China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,5,28]]},"reference":[{"key":"e_1_3_5_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-024-02589-8"},{"key":"e_1_3_5_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/gb4184"},{"key":"e_1_3_5_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/cc.26355"},{"key":"e_1_3_5_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.adw0053"},{"key":"e_1_3_5_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/21541264.2018.1539615"},{"key":"e_1_3_5_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adr9660"},{"key":"e_1_3_5_8_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.341545.120"},{"key":"e_1_3_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2024.05.007"},{"key":"e_1_3_5_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-23-2975"},{"issue":"23","key":"e_1_3_5_11_1","first-page":"2841","article-title":"CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma","volume":"141","author":"Yao Y","year":"2023","unstructured":"Yao Y, Ng JF, Park WD, Samur M, Morelli E, Encinas Mayoral J, Chyra Z, Xu Y, Derebail S, Epstein C, et al. CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma. Blood. 2023;141(23):2841\u20132852.","journal-title":"Blood"},{"key":"e_1_3_5_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b01985"},{"key":"e_1_3_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.024"},{"key":"e_1_3_5_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1831-7"},{"key":"e_1_3_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13393"},{"key":"e_1_3_5_16_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-0119"},{"key":"e_1_3_5_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c01171"},{"key":"e_1_3_5_18_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-16-0847"},{"key":"e_1_3_5_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-023-02750-w"},{"key":"e_1_3_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2019.02.012"},{"key":"e_1_3_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108229"},{"key":"e_1_3_5_22_1","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-2025-81"},{"key":"e_1_3_5_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/oncolo\/oyad215"},{"key":"e_1_3_5_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-40061-y"},{"key":"e_1_3_5_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm400887j"},{"key":"e_1_3_5_26_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.14.50"},{"key":"e_1_3_5_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.02.006"},{"key":"e_1_3_5_28_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384101.2018.1491236"},{"key":"e_1_3_5_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfaa092"}],"container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14756366.2026.2659998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T01:47:03Z","timestamp":1780019223000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14756366.2026.2659998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,28]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"alternative-id":["10.1080\/14756366.2026.2659998"],"URL":"https:\/\/doi.org\/10.1080\/14756366.2026.2659998","relation":{},"ISSN":["1475-6366","1475-6374"],"issn-type":[{"value":"1475-6366","type":"print"},{"value":"1475-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,28]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-02-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-23","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2659998"}}