{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T09:05:24Z","timestamp":1779440724644,"version":"3.53.1"},"reference-count":68,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T00:00:00Z","timestamp":1779408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"published-print":{"date-parts":[[2026,12,31]]},"DOI":"10.1080\/14756366.2026.2662446","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T08:14:44Z","timestamp":1779437684000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Mechanisms of traditional Chinese medicine in enhancing the efficacy and reducing the toxicity of immune checkpoint inhibitors\n                    <i>via<\/i>\n                    regulation of the tumor microenvironment and gut microbiota"],"prefix":"10.1080","volume":"41","author":[{"given":"Junying","family":"Pan","sequence":"first","affiliation":[{"name":"Department of Tuina, First Affiliated Hospital Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Yang","sequence":"additional","affiliation":[{"name":"Deparment of Geriatrics, The First Psychiatric Hospital in Harbin","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, First Affiliated Hospital Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghua","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Acupuncture, First Affiliated Hospital Heilongjiang University of Chinese Medicine","place":["Harbin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,5,22]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-031-97242-3_1","article-title":"Cancer immunotherapy-an overview","volume":"129","author":"Kulkarni P","year":"2025","unstructured":"Kulkarni P, Do D, Shrestha S, Leach B, Salgia R. Cancer immunotherapy-an overview. Cancer Treat Res. 2025;129:1\u201316.","journal-title":"Cancer Treat Res"},{"key":"e_1_3_4_3_1","doi-asserted-by":"crossref","first-page":"1566939","DOI":"10.3389\/fimmu.2025.1566939","article-title":"The efficacy and safety of PD-1\/PD-L1 inhibitors in combination with chemotherapy as a first-line treatment for unresectable, locally advanced, HER2-negative gastric or gastroesophageal junction cancer: a meta-analysis of randomized controlled trials","volume":"16","author":"Pu W","year":"2025","unstructured":"Pu W, Li S, Zhang J, Huang J, Li J, Jiang Y, Xu Z, Yi F, Lan Y, Xiao Q, et al. The efficacy and safety of PD-1\/PD-L1 inhibitors in combination with chemotherapy as a first-line treatment for unresectable, locally advanced, HER2-negative gastric or gastroesophageal junction cancer: a meta-analysis of randomized controlled trials. Front Immunol. 2025;16:1566939.","journal-title":"Front Immunol"},{"issue":"5","key":"e_1_3_4_4_1","doi-asserted-by":"crossref","first-page":"e011545","DOI":"10.1136\/jitc-2025-011545","article-title":"Associations between immune checkpoint inhibitor response, immune-related adverse events, and steroid use in RADIOHEAD: a prospective pan-tumor cohort study","volume":"13","author":"Quandt Z","year":"2025","unstructured":"Quandt Z, Lucas A, Liang SI, Yang E, Stone S, Fadlullah MZH, Bayless NL, Marr SS, Thompson MA, Padron LJ, et al. Associations between immune checkpoint inhibitor response, immune-related adverse events, and steroid use in RADIOHEAD: a prospective pan-tumor cohort study. J Immunother Cancer. 2025;13(5):e011545.","journal-title":"J Immunother Cancer"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01998-y"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-20-1638"},{"issue":"1","key":"e_1_3_4_7_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s12943-025-02245-6","article-title":"Traditional Chinese medicine in lung cancer treatment","volume":"24","author":"Xi Z","year":"2025","unstructured":"Xi Z, Dai R, Ze Y, Jiang X, Liu M, Xu H. Traditional Chinese medicine in lung cancer treatment. Mol Cancer. 2025;24(1):57.","journal-title":"Mol Cancer"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-025-00986-3"},{"issue":"1","key":"e_1_3_4_9_1","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s13020-023-00751-7","article-title":"Traditional Chinese medicine in the era of immune checkpoint inhibitor: theory, development, and future directions","volume":"18","author":"Yu YX","year":"2023","unstructured":"Yu YX, Wang S, Liu ZN, Zhang X, Hu ZX, Dong HJ, Lu XY, Zheng JB, Cui HJ. Traditional Chinese medicine in the era of immune checkpoint inhibitor: theory, development, and future directions. Chin Med. 2023;18(1):59.","journal-title":"Chin Med"},{"issue":"1","key":"e_1_3_4_10_1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/s41392-025-02226-7","article-title":"Single-cell transcriptomic analysis reveals gut microbiota-immunotherapy synergy through modulating tumor microenvironment","volume":"10","author":"Cao M","year":"2025","unstructured":"Cao M, Deng Y, Hao Q, Yan H, Wang QL, Dong C, Wu J, He Y, Huang LB, Xia X, et al. Single-cell transcriptomic analysis reveals gut microbiota-immunotherapy synergy through modulating tumor microenvironment. Signal Transduct Target Ther. 2025;10(1):140.","journal-title":"Signal Transduct Target Ther"},{"key":"e_1_3_4_11_1","doi-asserted-by":"crossref","first-page":"1366489","DOI":"10.3389\/fimmu.2024.1366489","article-title":"Potential application mechanism of traditional Chinese medicine in treating immune checkpoint inhibitor-induced colitis","volume":"15","author":"Wang J","year":"2024","unstructured":"Wang J, Guo Z, Shen M, Xie Q, Xiang H. Potential application mechanism of traditional Chinese medicine in treating immune checkpoint inhibitor-induced colitis. Front Immunol. 2024;15:1366489.","journal-title":"Front Immunol"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a037895"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40487-025-00381-z"},{"issue":"1","key":"e_1_3_4_14_1","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13045-025-01732-z","article-title":"The role of neoantigens and tumor mutational burden in cancer immunotherapy: advances, mechanisms, and perspectives","volume":"18","author":"Sun S","year":"2025","unstructured":"Sun S, Liu L, Zhang J, Sun L, Shu W, Yang Z, Yao H, Zhang Z. The role of neoantigens and tumor mutational burden in cancer immunotherapy: advances, mechanisms, and perspectives. J Hematol Oncol. 2025;18(1):84.","journal-title":"J Hematol Oncol"},{"key":"e_1_3_4_15_1","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.jconrel.2024.09.033","article-title":"Hydrogelation of peptides and carnosic acid as regulators of adaptive immunity against postoperative recurrence of cutaneous melanoma","volume":"375","author":"Ren M","year":"2024","unstructured":"Ren M, Wang Y, Zheng X, Yang W, Liu M, Xie S, Yao Y, Yan J, He W. Hydrogelation of peptides and carnosic acid as regulators of adaptive immunity against postoperative recurrence of cutaneous melanoma. J Control Release. 2024;375:654\u2013666.","journal-title":"J Control Release"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers17233817"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2022.e10450"},{"issue":"3","key":"e_1_3_4_18_1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1124\/pharmrev.121.000528","article-title":"ATP and adenosine metabolism in cancer: exploitation for therapeutic gain","volume":"74","author":"Yegutkin GG","year":"2022","unstructured":"Yegutkin GG, Boison D. ATP and adenosine metabolism in cancer: exploitation for therapeutic gain. Pharmacol Rev. 2022;74(3):797\u2013822.","journal-title":"Pharmacol Rev"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.804597"},{"issue":"1","key":"e_1_3_4_20_1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1161\/CIRCULATIONAHA.122.062551","article-title":"Expansion of pathogenic cardiac macrophages in immune checkpoint inhibitor myocarditis","volume":"149","author":"Ma P","year":"2024","unstructured":"Ma P, Liu J, Qin J, Lai L, Heo GS, Luehmann H, Sultan D, Bredemeyer A, Bajapa G, Feng G, et al. Expansion of pathogenic cardiac macrophages in immune checkpoint inhibitor myocarditis. Circulation. 2024;149(1):48\u201366.","journal-title":"Circulation"},{"issue":"4","key":"e_1_3_4_21_1","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1002\/ehf2.15281","article-title":"Immune checkpoint inhibitors and cardiovascular adverse events","volume":"12","author":"De Perna ML","year":"2025","unstructured":"De Perna ML, Rigamonti E, Zannoni R, Espeli V, Moschovitis G. Immune checkpoint inhibitors and cardiovascular adverse events. ESC Heart Fail. 2025;12(4):2404\u20132416.","journal-title":"ESC Heart Fail"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.01440"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.70183"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2407417"},{"key":"e_1_3_4_25_1","doi-asserted-by":"crossref","first-page":"1167975","DOI":"10.3389\/fimmu.2023.1167975","article-title":"Immune-related adverse events of immune checkpoint inhibitors: a review","volume":"14","author":"Yin Q","year":"2023","unstructured":"Yin Q, Wu L, Han L, Zheng X, Tong R, Li L, Bai L, Bian Y. Immune-related adverse events of immune checkpoint inhibitors: a review. Front Immunol. 2023;14:1167975.","journal-title":"Front Immunol"},{"issue":"7","key":"e_1_3_4_26_1","doi-asserted-by":"crossref","first-page":"e2413122","DOI":"10.1002\/advs.202413122","article-title":"Berberine derivative B68 promotes tumor immune clearance by dual-targeting BMI1 for senescence induction and CSN5 for PD-L1 degradation","volume":"12","author":"Hu H","year":"2025","unstructured":"Hu H, Wang Q, Yu D, Tao X, Guo M, Tian S, Zhang Q, Xu M, Geng X, Zhang H, et al. Berberine derivative B68 promotes tumor immune clearance by dual-targeting BMI1 for senescence induction and CSN5 for PD-L1 degradation. Adv Sci. 2025;12(7):e2413122.","journal-title":"Adv Sci"},{"issue":"4","key":"e_1_3_4_27_1","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1136\/gutjnl-2020-321031","article-title":"Ginseng polysaccharides alter the gut microbiota and kynurenine\/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1\/programmed cell death ligand 1 (anti-PD-1\/PD-L1) immunotherapy","volume":"71","author":"Huang J","year":"2022","unstructured":"Huang J, Liu D, Wang Y, Liu L, Li J, Yuan J, Jiang Z, Jiang Z, Hsiao WW, Liu H, et al. Ginseng polysaccharides alter the gut microbiota and kynurenine\/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1\/programmed cell death ligand 1 (anti-PD-1\/PD-L1) immunotherapy. Gut. 2022;71(4):734\u2013745.","journal-title":"Gut"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.118231"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21989"},{"issue":"1","key":"e_1_3_4_30_1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/s12964-023-01184-3","article-title":"Single-cell RNA sequencing reveals enhanced antitumor immunity after combined application of PD-1 inhibitor and Shenmai injection in non-small cell lung cancer","volume":"21","author":"Yu D","year":"2023","unstructured":"Yu D, Yang P, Lu X, Huang S, Liu L, Fan X. Single-cell RNA sequencing reveals enhanced antitumor immunity after combined application of PD-1 inhibitor and Shenmai injection in non-small cell lung cancer. Cell Commun Signal. 2023;21(1):169.","journal-title":"Cell Commun Signal"},{"issue":"1","key":"e_1_3_4_31_1","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s12906-024-04444-y","article-title":"Huang Lian Jie Du decoction enhances the anti-tumor efficacy of immune checkpoint inhibitors by activating TLR7\/8 signalling in melanoma","volume":"24","author":"Liu S","year":"2024","unstructured":"Liu S, Zhang Y, Zhu X, He S, Liu X, Lv X, Zuo F, Wu J. Huang Lian Jie Du decoction enhances the anti-tumor efficacy of immune checkpoint inhibitors by activating TLR7\/8 signalling in melanoma. BMC Complement Med Ther. 2024;24(1):156.","journal-title":"BMC Complement Med Ther"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.06.014"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2014.07.028"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/cimb47100842"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/07357907.2023.2194420"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.154667"},{"issue":"39","key":"e_1_3_4_37_1","doi-asserted-by":"crossref","first-page":"8203","DOI":"10.2174\/0929867328666210720143721","article-title":"The role of tumor associated macrophages (TAMs) in cancer progression, chemoresistance, angiogenesis and metastasis \u2013 current status","volume":"28","author":"Dallavalasa S","year":"2021","unstructured":"Dallavalasa S, Beeraka NM, Basavaraju CG, Tulimilli SV, Sadhu SP, Rajesh K, Aliev G, Madhunapantula SV. The role of tumor associated macrophages (TAMs) in cancer progression, chemoresistance, angiogenesis and metastasis \u2013 current status. Curr Med Chem. 2021;28(39):8203\u20138236.","journal-title":"Curr Med Chem"},{"issue":"1","key":"e_1_3_4_38_1","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41392-022-01304-4","article-title":"Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy","volume":"8","author":"Yang L","year":"2023","unstructured":"Yang L, Li A, Wang Y, Zhang Y. Intratumoral microbiota: roles in cancer initiation, development and therapeutic efficacy. Signal Transduct Target Ther. 2023;8(1):35.","journal-title":"Signal Transduct Target Ther"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1351-4"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S409292"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.02.015"},{"issue":"1","key":"e_1_3_4_42_1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13020-025-01113-1","article-title":"Traditional Chinese medicine Youguiyin decoction ameliorate glucocorticoid-induced osteonecrosis in rat by modulating ROS\/PHD2\/HIF-1\u03b1 oxidative stress signaling pathway in bone marrow mesenchymal stem cells","volume":"20","author":"Xi H","year":"2025","unstructured":"Xi H, Chen H, Fu J, He S, Liu X, Sun G, Du B. Traditional Chinese medicine Youguiyin decoction ameliorate glucocorticoid-induced osteonecrosis in rat by modulating ROS\/PHD2\/HIF-1\u03b1 oxidative stress signaling pathway in bone marrow mesenchymal stem cells. Chin Med. 2025;20(1):55.","journal-title":"Chin Med"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.1c00647"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13400"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3455"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctrv.2020.102017"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2019.12.011"},{"issue":"4","key":"e_1_3_4_48_1","first-page":"227","article-title":"Effect of Traditional Chinese medicine on CTLA-4 and PD-1 proteins in CTL cells in SiHa-CTL-Treg co-culture system","volume":"37","author":"Lou JY","year":"2014","unstructured":"Lou JY, Cao Y, Jin Z. Effect of Traditional Chinese medicine on CTLA-4 and PD-1 proteins in CTL cells in SiHa-CTL-Treg co-culture system. J Beijing Univ Chinese Med. 2014;37(4):227\u2013230.","journal-title":"J Beijing Univ Chinese Med"},{"issue":"6","key":"e_1_3_4_49_1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41419-019-1638-6","article-title":"Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment","volume":"10","author":"Lv J","year":"2019","unstructured":"Lv J, Jia Y, Li J, Kuai W, Li Y, Guo F, Xu X, Zhao Z, Lv J, Li Z. Gegen Qinlian decoction enhances the effect of PD-1 blockade in colorectal cancer with microsatellite stability by remodelling the gut microbiota and the tumour microenvironment. Cell Death Dis. 2019;10(6):415.","journal-title":"Cell Death Dis"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.12.013"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-025-03888-z"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.17409"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0238-9"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104533"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2020.06.004"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.817600"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106805"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2025.2493901"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v27.i41.7190"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116581"},{"key":"e_1_3_4_61_1","doi-asserted-by":"crossref","first-page":"1582559","DOI":"10.3389\/fmicb.2025.1582559","article-title":"Modified Pulsatilla decoction ameliorates ulcerative colitis by affecting gut microbiota and metabolite profiles","volume":"16","author":"Fu Z","year":"2025","unstructured":"Fu Z, Xie X, Wang Y, Wang Z, Wu A, Ye S, Liu Y. Modified Pulsatilla decoction ameliorates ulcerative colitis by affecting gut microbiota and metabolite profiles. Front Microbiol. 2025;16:1582559.","journal-title":"Front Microbiol"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-021-01070-6"},{"issue":"30","key":"e_1_3_4_63_1","doi-asserted-by":"crossref","first-page":"e2301136","DOI":"10.1002\/advs.202301136","article-title":"Use of deep-learning assisted assessment of cardiac parameters in zebrafish to discover cyanidin chloride as a novel Keap1 inhibitor against doxorubicin-induced cardiotoxicity","volume":"10","author":"Liu C","year":"2023","unstructured":"Liu C, Wang Y, Zeng Y, Kang Z, Zhao H, Qi K, Wu H, Zhao L, Wang Y. Use of deep-learning assisted assessment of cardiac parameters in zebrafish to discover cyanidin chloride as a novel Keap1 inhibitor against doxorubicin-induced cardiotoxicity. Adv Sci. 2023;10(30):e2301136.","journal-title":"Adv Sci"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154407"},{"key":"e_1_3_4_65_1","doi-asserted-by":"crossref","first-page":"123838","DOI":"10.1016\/j.carbpol.2025.123838","article-title":"Structural feature and antitumor activity of a N-acetylglucosamine containing polysaccharide from Ganoderma sinense","volume":"366","author":"Feng M","year":"2025","unstructured":"Feng M, Fu F, Lei M, Luo W, Su Y, Xie Y, Wang Q, Zhang D, Yu Q, Yan C. Structural feature and antitumor activity of a N-acetylglucosamine containing polysaccharide from Ganoderma sinense. Carbohydr Polym. 2025;366:123838.","journal-title":"Carbohydr Polym"},{"key":"e_1_3_4_66_1","doi-asserted-by":"crossref","first-page":"628358","DOI":"10.3389\/fimmu.2021.628358","article-title":"Total flavonoids of Glycyrrhiza uralensis alleviates irinotecan-induced colitis via modification of gut microbiota and fecal metabolism","volume":"12","author":"Yue SJ","year":"2021","unstructured":"Yue SJ, Qin YF, Kang A, Tao HJ, Zhou GS, Chen YY, Jiang JQ, Tang YP, Duan JA. Total flavonoids of Glycyrrhiza uralensis alleviates irinotecan-induced colitis via modification of gut microbiota and fecal metabolism. Front Immunol. 2021;12:628358.","journal-title":"Front Immunol"},{"issue":"1","key":"e_1_3_4_67_1","first-page":"32","article-title":"Heterogeneity of intratumoral microbiota within the tumor microenvironment and relationship to tumor development","volume":"1","author":"Gao Z","year":"2025","unstructured":"Gao Z, Jiang A, Li Z, Zhu L, Mou W, Shen W, Luo P, Tang B, Zhang J, Lin A. Heterogeneity of intratumoral microbiota within the tumor microenvironment and relationship to tumor development. Med Res. 2025;1(1):32\u201361.","journal-title":"Med Res"},{"key":"e_1_3_4_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-020-0400-z"},{"key":"e_1_3_4_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2025.03.013"}],"container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14756366.2026.2662446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T08:14:48Z","timestamp":1779437688000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14756366.2026.2662446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,22]]},"references-count":68,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"alternative-id":["10.1080\/14756366.2026.2662446"],"URL":"https:\/\/doi.org\/10.1080\/14756366.2026.2662446","relation":{},"ISSN":["1475-6366","1475-6374"],"issn-type":[{"value":"1475-6366","type":"print"},{"value":"1475-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,22]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-02-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2662446"}}