{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T03:35:05Z","timestamp":1784345705190,"version":"3.55.0"},"reference-count":63,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Guido Berlucchi Foundation","award":["G43C23002440001"],"award-info":[{"award-number":["G43C23002440001"]}]},{"name":"Guido Berlucchi Foundation","award":["Piano di sostegno alla Ricerca 2023- LINEA 2"],"award-info":[{"award-number":["Piano di sostegno alla Ricerca 2023- LINEA 2"]}]},{"name":"Ferrero Foundation","award":["GIAE_RILO_24_02"],"award-info":[{"award-number":["GIAE_RILO_24_02"]}]},{"name":"Ferrero Foundation","award":["BRUNO_S_FIL"],"award-info":[{"award-number":["BRUNO_S_FIL"]}]},{"DOI":"10.13039\/501100009877","name":"Regione Calabria","doi-asserted-by":"publisher","award":["RF-2019\u201312370255"],"award-info":[{"award-number":["RF-2019\u201312370255"]}],"id":[{"id":"10.13039\/501100009877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"published-print":{"date-parts":[[2026,12,31]]},"DOI":"10.1080\/14756366.2026.2664708","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T14:17:46Z","timestamp":1778509066000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":1,"title":["Targeting ALDH7A1 with covalent inhibitors reveals new chemical space for prostate cancer therapy"],"prefix":"10.1080","volume":"41","author":[{"given":"Raffaella","family":"Gallo","sequence":"first","affiliation":[{"name":"Department of Experimental and Clinical Medicine, \u201cMagna Gr\u00e6cia\u201d University of Catanzaro","place":["Catanzaro, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Scarano","sequence":"additional","affiliation":[{"name":"Department of Food and Drug, University of Parma","place":["Parma, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonora","family":"Gianquinto","sequence":"additional","affiliation":[{"name":"Department of Drug Science and Technology, University of Turin","place":["Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Franzini","sequence":"additional","affiliation":[{"name":"Biopharmanet-TEC, University of Parma","place":["Parma, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Antonini","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Milan","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Montalbano","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Milan","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camillo","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, \u201cMagna Gr\u00e6cia\u201d University of Catanzaro","place":["Catanzaro, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Conti","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Milan","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Spyrakis","sequence":"additional","affiliation":[{"name":"Department of Drug Science and Technology, University of Turin","place":["Turin, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Borsari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, University of Milan","place":["Milan, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Bruno","sequence":"additional","affiliation":[{"name":"Department of Food and Drug, University of Parma","place":["Parma, Italy"]},{"name":"Biopharmanet-TEC, University of Parma","place":["Parma, Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,5,11]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21834"},{"issue":"6","key":"e_1_3_4_3_1","first-page":"485","article-title":"Prostate cancer statistics, 2025","volume":"75","author":"Kratzer TB","year":"2025","unstructured":"Kratzer TB, Mazzitelli N, Star J, Dahut WL, Jemal A, Siegel RL. Prostate cancer statistics, 2025. CA Cancer J Clin. 2025;75(6):485\u2013497.","journal-title":"CA Cancer J Clin"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000519861"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15424"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biochem3030009"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trecan.2020.04.010"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-025-02245-4"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242317111"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.8b00256"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.574394"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0294-0"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-3006"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.88057"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-020-06899-x"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.201"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13184703"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2011.02.016"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.10.053"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-12-2857"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.53935"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-011-9395-7"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.530"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/cb500977q"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2011.10.007"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.299"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.1006340"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867330666230408200401"},{"key":"e_1_3_4_29_1","first-page":"2763","article-title":"A Phase I and pharmacological study of the glutamine antagonist acivicin with the amino acid solution aminosyn in patients with advanced solid malignancies","volume":"4","author":"Hidalgo M","year":"1998","unstructured":"Hidalgo M, Rodriguez G, Kuhn JG, Brown T, Weiss G, MacGovren JP, Von Hoff DD, Rowinsky EK. A Phase I and pharmacological study of the glutamine antagonist acivicin with the amino acid solution aminosyn in patients with advanced solid malignancies. Clin Cancer Res Off J Am Assoc Cancer Res. 1998;4:2763\u20132770.","journal-title":"Clin Cancer Res Off J Am Assoc Cancer Res"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0014047"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201700118"},{"issue":"1","key":"e_1_3_4_32_1","first-page":"175","article-title":"The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501)","volume":"27","author":"Allen L","year":"1980","unstructured":"Allen L, Meck R, Yunis A. The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501). Res Commun Chem Pathol Pharmacol. 1980;27(1):175\u2013182.","journal-title":"Res Commun Chem Pathol Pharmacol"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.6.2360"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201500496"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4SC02339K"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.04.033"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112740"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115286"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28073172"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14133153"},{"key":"e_1_3_4_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2017.01.002"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.5b00754"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.077925"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm2013248"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2012.04.010"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2012.11.015"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/pro.4131"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)60901-9"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20960"},{"issue":"1","key":"e_1_3_4_50_1","first-page":"96","article-title":"Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators","volume":"4","author":"Mondal D","year":"2021","unstructured":"Mondal D, Narwani D, Notta S, Ghaffar D, Mardhekar N, Quadri SSA. Oxidative stress and redox signaling in CRPC progression: therapeutic potential of clinically-tested Nrf2-activators. Cancer Drug Resist. 2021;4(1):96\u2013124.","journal-title":"Cancer Drug Resist"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(99)00010-X"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24076689"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.03.019"},{"key":"e_1_3_4_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2025.118095"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.4c00181"},{"key":"e_1_3_4_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.1c00354"},{"key":"e_1_3_4_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201202246"},{"key":"e_1_3_4_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(85)90014-4"},{"key":"e_1_3_4_59_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci500118s"},{"key":"e_1_3_4_60_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq054"},{"key":"e_1_3_4_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.04.019"},{"key":"e_1_3_4_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-015-2032-x"},{"key":"e_1_3_4_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-07754-0"},{"key":"e_1_3_4_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2023.08.005"}],"container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14756366.2026.2664708","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T14:19:05Z","timestamp":1778941145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14756366.2026.2664708"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,11]]},"references-count":63,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"alternative-id":["10.1080\/14756366.2026.2664708"],"URL":"https:\/\/doi.org\/10.1080\/14756366.2026.2664708","relation":{},"ISSN":["1475-6366","1475-6374"],"issn-type":[{"value":"1475-6366","type":"print"},{"value":"1475-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,11]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-01-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-02","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-11","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2664708"}}