{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:02:24Z","timestamp":1790647344836,"version":"4.1.0"},"reference-count":47,"publisher":"Informa UK Limited","issue":"1","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"funder":[{"name":"Suqian Sci&Tech Program","award":["KY202426"],"award-info":[{"award-number":["KY202426"]}]},{"name":"Campus Collaborative Innovation Research Project of Jiangsu Medical Vocational College","award":["202491004"],"award-info":[{"award-number":["202491004"]}]},{"name":"Scientific Research Project of Yancheng City Health Commission","award":["YK2025182"],"award-info":[{"award-number":["YK2025182"]}]},{"name":"Natural Science Foundation of Huai\u2019an","award":["HAB202323"],"award-info":[{"award-number":["HAB202323"]}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"published-print":{"date-parts":[[2026,12,31]]},"DOI":"10.1080\/14756366.2026.2724128","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:22:36Z","timestamp":1790644956000},"update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Integrated computational and experimental identification of a novel ML-IAP-targeting peptide with antiproliferative activity in leukaemia cells"],"prefix":"10.1080","volume":"41","author":[{"given":"Yan","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Hematology, The Affiliated Huai\u2019an Hospital of Xuzhou Medical University","place":["Huai\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaozhi","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Analysis, China Pharmaceutical University","place":["Nanjing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition\/Department of Hematology, Binhai County People\u2019s Hospital","place":["Yancheng, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated Huai\u2019an Hospital of Xuzhou Medical University","place":["Huai\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Suqian No. 1 People\u2019s Hospital","place":["Suqian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinrong","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Hematology, Suqian No. 1 People\u2019s Hospital","place":["Suqian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Suqian No. 1 People\u2019s Hospital","place":["Suqian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotian","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology, The Affiliated Huai\u2019an Hospital of Xuzhou Medical University","place":["Huai\u2019an, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junshuai","family":"Yue","sequence":"additional","affiliation":[{"name":"Department of Hematology, Suqian No. 1 People\u2019s Hospital","place":["Suqian, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"e_1_3_3_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.904292"},{"key":"e_1_3_3_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0325937"},{"key":"e_1_3_3_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13071652"},{"key":"e_1_3_3_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-026-07966-w"},{"key":"e_1_3_3_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25126639"},{"key":"e_1_3_3_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2022.280800"},{"key":"e_1_3_3_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26094005"},{"key":"e_1_3_3_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2014.00003"},{"issue":"22","key":"e_1_3_3_10_1","first-page":"4390","article-title":"In vitro application of RNA interference to silence livin gene expression to induce apoptosis in leukemia cells","volume":"19","author":"Lv J","year":"2015","unstructured":"Lv J, Qin Z-P, Zheng MF, Chen ZC, Wang Z. In vitro application of RNA interference to silence livin gene expression to induce apoptosis in leukemia cells. Eur Rev Med Pharmacol Sci. 2015;19(22):4390\u20134396.","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"e_1_3_3_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00781-8"},{"key":"e_1_3_3_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003670200"},{"key":"e_1_3_3_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2006.07.018"},{"key":"e_1_3_3_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401959"},{"key":"e_1_3_3_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90509-O"},{"key":"e_1_3_3_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02176-0"},{"key":"e_1_3_3_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2022.985363"},{"key":"e_1_3_3_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms14011763"},{"key":"e_1_3_3_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms13092031"},{"key":"e_1_3_3_20_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2022.063"},{"key":"e_1_3_3_21_1","doi-asserted-by":"publisher","DOI":"10.3233\/THC-199025"},{"issue":"5","key":"e_1_3_3_22_1","first-page":"4587","article-title":"XIAP impairs mitochondrial function during apoptosis by regulating the Bcl-2 family in renal cell carcinoma","volume":"15","author":"Chen C","year":"2018","unstructured":"Chen C, Liu TS, Zhao SC, Yang WZ, Chen ZP, Yan Y. XIAP impairs mitochondrial function during apoptosis by regulating the Bcl-2 family in renal cell carcinoma. Exp Ther Med. 2018;15(5):4587\u20134593.","journal-title":"Exp Ther Med"},{"key":"e_1_3_3_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-017-0560-7"},{"key":"e_1_3_3_24_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD09112"},{"key":"e_1_3_3_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206973"},{"issue":"5","key":"e_1_3_3_26_1","first-page":"7707","article-title":"Silencing Livin improved the sensitivity of colon cancer cells to 5-fluorouracil by regulating crosstalk between apoptosis and autophagy","volume":"15","author":"Liu S","year":"2018","unstructured":"Liu S, Li X, Li Q, Liu H, Shi Y, Zhuo H, Li C, Zhu H. Silencing Livin improved the sensitivity of colon cancer cells to 5-fluorouracil by regulating crosstalk between apoptosis and autophagy. Oncol Lett. 2018;15(5):7707\u20137715.","journal-title":"Oncol Lett"},{"key":"e_1_3_3_27_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2013.1925"},{"key":"e_1_3_3_28_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01409.x"},{"issue":"1","key":"e_1_3_3_29_1","first-page":"5","article-title":"Bioactive peptides for anticancer therapies","volume":"4","author":"Zhang Y","year":"2023","unstructured":"Zhang Y, Wang C, Zhang W, Li X. Bioactive peptides for anticancer therapies. Biomater Transl. 2023;4(1):5\u201317.","journal-title":"Biomater Transl"},{"key":"e_1_3_3_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-023-01016-x"},{"key":"e_1_3_3_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241612931"},{"key":"e_1_3_3_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112045200"},{"key":"e_1_3_3_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/35050012"},{"key":"e_1_3_3_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/35050006"},{"key":"e_1_3_3_35_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207578200"},{"key":"e_1_3_3_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.9.3419"},{"key":"e_1_3_3_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm735"},{"key":"e_1_3_3_38_1","doi-asserted-by":"publisher","DOI":"10.2174\/156802608786786624"},{"key":"e_1_3_3_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci800130k"},{"key":"e_1_3_3_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.1c12075"},{"key":"e_1_3_3_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.5c02435"},{"key":"e_1_3_3_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c02433"},{"key":"e_1_3_3_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/ci500020m"},{"key":"e_1_3_3_44_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01572"},{"key":"e_1_3_3_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201904969"},{"key":"e_1_3_3_46_1","doi-asserted-by":"publisher","DOI":"10.5045\/br.2018.53.1.53"},{"key":"e_1_3_3_47_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-04-0641"},{"key":"e_1_3_3_48_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-010-0300-3"}],"container-title":["Journal of Enzyme Inhibition and Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14756366.2026.2724128","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/14756366.2026.2724128","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14756366.2026.2724128","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:22:38Z","timestamp":1790644958000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14756366.2026.2724128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,28]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,12,31]]}},"alternative-id":["10.1080\/14756366.2026.2724128"],"URL":"https:\/\/doi.org\/10.1080\/14756366.2026.2724128","relation":{},"ISSN":["1475-6366","1475-6374"],"issn-type":[{"value":"1475-6366","type":"print"},{"value":"1475-6374","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,28]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ienz20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"2724128"}}