{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:29:36Z","timestamp":1787315376047,"version":"build-2736575974"},"reference-count":136,"publisher":"Informa UK Limited","issue":"11","funder":[{"DOI":"10.13039\/100004334","name":"Merck & Co., Inc., Kenilworth, NJ, USA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004334","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Vaccines"],"published-print":{"date-parts":[[2017,11,2]]},"DOI":"10.1080\/14760584.2017.1383158","type":"journal-article","created":{"date-parts":[[2017,9,28]],"date-time":"2017-09-28T06:01:56Z","timestamp":1506578516000},"page":"1119-1139","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":60,"title":["9-Valent human papillomavirus vaccine: a review of the clinical development program"],"prefix":"10.1080","volume":"16","author":[{"given":"Alain","family":"Luxembourg","sequence":"first","affiliation":[{"name":"Merck & Co., Inc., Kenilworth, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Moeller","sequence":"additional","affiliation":[{"name":"Merck & Co., Inc., Kenilworth, NJ, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2017,10,9]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2016.09.006"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30716"},{"key":"CIT0004","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(16)30143-7"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02726-07"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(00)80449-9"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70230-8"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20244"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.04.108"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2015.08.004"},{"key":"CIT0011","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(14)71073-4"},{"key":"CIT0012","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw354"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-1968"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.01.076"},{"key":"CIT0015","first-page":"f5906","volume":"347","author":"Arnheim-Dahlstrom L","year":"2013","journal-title":"B"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3181b77906"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2011.02467.x"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.08.106"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1168952"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1111\/joim.12155"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2017.01.005"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2012.1451"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1183847"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1007\/s40264-013-0039-5"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.16946"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1612296"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2009.1201"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000793"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(12)70187-1"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.3201\/eid2210.160675"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.pvr.2017.01.001"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2017.01.007"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.28963"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1086\/597071"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-14-0410"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1586\/14760584.2015.1089174"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2015.06.001"},{"key":"CIT0038","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1128\/JVI.67.1.315-322.1993","volume":"67","author":"Hagensee ME","year":"1993","journal-title":"J Virol"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.24.12180"},{"key":"CIT0040","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1128\/JVI.67.4.1936-1944.1993","volume":"67","author":"Rose RC","year":"1993","journal-title":"J Virol"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(91)90772-4"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20696"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1038\/sj.clpt.6100055"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-9-52"},{"key":"CIT0045","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.1128\/JVI.69.6.3959-3963.1995","volume":"69","author":"Breitburd F","year":"1995","journal-title":"J Virol"},{"key":"CIT0046","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2006.05.119","volume":"24","author":"Inglis S","year":"2006","journal-title":"Vaccine"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1996.0220"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.25.11553"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.55.4.244"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2004.02.020"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2003.11.058"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa020586"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.4065\/80.5.601"},{"key":"CIT0054","unstructured":"VRBPAC background document: Gardasil HPV quadrivalent vaccine. United States Food and Drug Administration; 2006 [cited 2017 Jan 14. Available from: http:\/\/www.fda.gov\/ohrms\/dockets\/ac\/06\/briefing\/2006-4222B3.pdf"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061741"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa061760"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(05)70101-7"},{"key":"CIT0058","first-page":"c3493","volume":"340","author":"FUTURE II Study Group","year":"2010","journal-title":"B"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2011.07.003"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1158\/1940-6207.CAPR-09-0031"},{"key":"CIT0061","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0909537"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1010971"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60691-7"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2006-0461"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.1625"},{"key":"CIT0066","unstructured":"Statistical analysis and evaluation, anal cancer, Gardasil. United States Food and Drug Administration; 2010 cited 2016 Dec 30. Available from: http:\/\/www.fda.gov\/downloads\/BiologicsBloodVaccines\/Vaccines\/ApprovedProducts\/UCM247722.pdf"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2015.1012010"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1405044"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)31821-4"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.06.088"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-3745"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.17615"},{"key":"CIT0073","first-page":"210","volume":"4","author":"Billich A","year":"2003","journal-title":"Curr Opin Investig Drugs"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)60946-5"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1016\/j.jadohealth.2007.02.015"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60920-X"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1177\/1740774514552110"},{"key":"CIT0078","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2015.02.009"},{"key":"CIT0079","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2015.1009819"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-4199"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2015.08.059"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000694"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.7883\/yoken.JJID.2016.299"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000000773"},{"key":"CIT0085","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2016.06.056"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1016\/j.cct.2016.10.006"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.04.106"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(14)70481-4"},{"key":"CIT0089","unstructured":"European Medicines Agency (EMEA). Committee for medicinal products for human use (CHMP), guideline on the choice of the noninferiority margin. EMEA; 2005. Doc Ref. EMEA\/EPMP\/EWP\/21858\/99."},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1080\/10543400600719251"},{"key":"CIT0091","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.05208-11"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2017.07.017"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2009-2336"},{"key":"CIT0094","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1097\/INF.0b013e3181e28e6e","volume":"29","author":"Vesikari T","year":"2010","journal-title":"Pediatr Infect Dis J"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-4387"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1510069"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph110505069"},{"key":"CIT0098","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2702.2009.03041.x"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00236-10"},{"key":"CIT0100","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00235-10"},{"key":"CIT0101","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1128\/CDLI.12.8.959-969.2005","volume":"12","author":"Dias D","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"key":"CIT0102","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1128\/CDLI.10.1.108-115.2003","volume":"10","author":"Opalka D","year":"2003","journal-title":"Clin Diagn Lab Immunol"},{"key":"CIT0103","doi-asserted-by":"publisher","DOI":"10.4161\/hv.4.2.5261"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00773-13"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.4161\/hv.29205"},{"key":"CIT0106","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2014.03.040"},{"key":"CIT0107","unstructured":"United States Food and Drug Administration draft guidance for industry on adaptive design clinical trials for drugs and biologics. United States Food and Drug Administration; 2010 cited 2016 Dec 26. Available from: http:\/\/www.fda.gov\/downloads\/Drugs\/GuidanceComplianceRegulatoryInformation\/Guidances\/UCM201790.pdf"},{"key":"CIT0108","unstructured":"EMA-EFPIA 2nd workshop on adaptive design in confirmatory trials. European Medicines Agency (EMA), European Federation of Pharmaceutical Industries and Associations (EFPIA); 2010 [cited 2016 Dec 26. Available from: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Minutes\/2010\/04\/WC500089206.pdf"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1177\/2168479015604181"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2010-1722E"},{"key":"CIT0111","unstructured":"Guidance for industry for the evaulation of combination vaccines for preventable disease: production, testing and clinical studies. United States Food and Drug Administration; 1997. Available from: http:\/\/www.fda.gov\/downloads\/biologicsbloodvaccines\/guidancecomplianceregulatoryinformation\/guidances\/vaccines\/UCM175909.pdf.1997"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1002\/sim.3273"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4408"},{"key":"CIT0114","first-page":"300","volume":"64","author":"Petrosky E","year":"2015","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"CIT0115","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1140288"},{"key":"CIT0116","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6549a5"},{"key":"CIT0117","unstructured":"Bundesministeriums f\u00fcr Gesundheit und Frauen. Impfplan \u00d6sterreich 2017; 2017 [cited 2017 Jun 22. Available from: http:\/\/www.bmgf.gv.at\/cms\/home\/attachments\/2\/8\/1\/CH1100\/CMS1452867487477\/impfplan.pdf"},{"key":"CIT0118","unstructured":"Updated recommendations on human papillomavirus (HPV) vaccines: 9-valent HPV vaccine and clarification of minimum intervals between doses in the HPV immunization schedule. National Advisory Committee on Immunization (NACI); 2016 cited 2017 Jan 7. Available from: http:\/\/www.healthycanadians.gc.ca\/publications\/healthy-living-viesaine\/human-papillomavirus-9-valent-vaccine-update-recommendation-mises-a-jour-recommendations-papillome-humain-vaccin-nonavalent\/index-eng.php"},{"key":"CIT0119","unstructured":"Pr\u00e9vention des infections \u00e0 HPV: place du vaccin Gardasil 9. Haut Conseil de la Sant\u00e9 Publique; 2017 [cited 2017 Jun 22. Available from: http:\/\/www.hcsp.fr\/explore.cgi\/avisrapportsdomaine?clefr=602"},{"key":"CIT0120","unstructured":"Epidemiologisches bulletin. Robert Koch Institute; 2017 cited 2017 Jun 22. Available from: http:\/\/www.rki.de\/DE\/Content\/Infekt\/EpidBull\/Archiv\/2016\/Ausgaben\/34_16.pdf?__blob=publicationFile"},{"key":"CIT0121","unstructured":"Norma N\u00ba.016\/2016 de 16\/ 12\/2016. Dire\u00e7\u00e3o-Geral da Sa\u00fade; 2017 [cited 2017 Jun 22. Available from: https:\/\/www.dgs.pt\/directrizes-da-dgs\/normas-e-circulares-normativas\/norma-n-0162016-de-16122016.aspx"},{"key":"CIT0122","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2003.09.054"},{"key":"CIT0123","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.01.042"},{"key":"CIT0124","doi-asserted-by":"publisher","DOI":"10.1001\/jama.291.17.2100"},{"key":"CIT0125","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2016.11.020"},{"key":"CIT0126","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2011.07.096"},{"key":"CIT0127","doi-asserted-by":"publisher","DOI":"10.1080\/21645515.2016.1157673"},{"key":"CIT0128","doi-asserted-by":"publisher","DOI":"10.4161\/hv.29137"},{"key":"CIT0129","doi-asserted-by":"publisher","DOI":"10.1080\/14760584.2017.1256778"},{"key":"CIT0130","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.67.2014"},{"key":"CIT0131","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.16393"},{"key":"CIT0132","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.12.037"},{"key":"CIT0133","unstructured":"Statement on Safety of HPV Vaccines. Global advisory committee on vaccine safety. World Health Organization (WHO); 2015 cited 2017 Jun 20. Available from: http:\/\/www.who.int\/vaccine_safety\/committee\/GACVS_HPV_statement_17Dec2015.pdf?ua=1"},{"key":"CIT0134","doi-asserted-by":"publisher","DOI":"10.1038\/528009a"},{"key":"CIT0135","unstructured":"Guide to introducing HPV vaccine into national immunization programmes. World Health Organization (WHO); 2016 cited 2017 Mar 15. Available from: http:\/\/www.who.int\/immunization\/documents\/WHO_IVB_16.02\/en\/"},{"key":"CIT0136","unstructured":"WHO HPV Vaccine Communication. Special considerations for a unique vaccine. World Health Organization (WHO); 2016 cited 2017 Mar 15. Available from: http:\/\/apps.who.int\/iris\/bitstream\/10665\/250279\/1\/WHO-IVB-16.02-eng.pdf?ua=1"}],"container-title":["Expert Review of Vaccines"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14760584.2017.1383158","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,15]],"date-time":"2020-08-15T19:12:39Z","timestamp":1597518759000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14760584.2017.1383158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,9]]},"references-count":136,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11,2]]}},"alternative-id":["10.1080\/14760584.2017.1383158"],"URL":"https:\/\/doi.org\/10.1080\/14760584.2017.1383158","relation":{},"ISSN":["1476-0584","1744-8395"],"issn-type":[{"value":"1476-0584","type":"print"},{"value":"1744-8395","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,9]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierv20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierv20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2017-04-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-09-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}