{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:37:01Z","timestamp":1793086621877,"version":"4.5.0"},"reference-count":53,"publisher":"Informa UK Limited","issue":"10","license":[{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T00:00:00Z","timestamp":1790985600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Cardiovascular Therapy"],"published-print":{"date-parts":[[2026,10,3]]},"DOI":"10.1080\/14779072.2026.2745393","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T16:31:59Z","timestamp":1791304319000},"page":"893-905","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":0,"title":["Recent advances in hypertension genomics and RNA interference-based therapeutics: the key to future management?"],"prefix":"10.1080","volume":"24","author":[{"given":"Panagiota","family":"Anyfanti","sequence":"first","affiliation":[{"name":"Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Antza","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Korki","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Aintinidou","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyriakos","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Angeloudi","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasilios","family":"Kotsis","sequence":"additional","affiliation":[{"name":"Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32008-2"},{"key":"e_1_3_4_4_1","unstructured":"WHO Team. Global report on hypertension. The race against a silent killer [Internet]. [cited 2026 Jun 15]. Available from: https:\/\/www.who.int\/publications\/i\/item\/9789240081062"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)01330-1"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2015.142"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpad121"},{"key":"e_1_3_4_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00263"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.121.16498"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/10641963.2022.2132012"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ASN.0000032524.13069.88"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx134"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1375\/twin.9.2.205"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92762-6"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1002822"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2344"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10405"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0303-9"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0205-x"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.14535"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0353311"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.123.21710"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.04.031"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-018-0018-x"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-018-0183-z"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16471"},{"key":"e_1_3_4_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31080-2"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-68878-3"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.123.319220"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.125.26399"},{"key":"e_1_3_4_31_1","unstructured":"Fda C. Long term follow-up after administration of human gene therapy Products; guidance for industry. 2020. Available from: https:\/\/www.fda.gov\/vaccines-blood-biologics\/guidance-compliance-"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2021.04.004"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/circ.152.suppl_3.4362610"},{"key":"e_1_3_4_34_1","unstructured":"ClinicalTrials.gov. A randomized double-blind placebo-controlled multicenter 24 months treatment duration dose finding study to evaluate efficacy safety and pharmacodynamics of IBI3016 in mild to moderate hypertensive patients [internet]. U.S. National Library of Medicine; [cited 2026 Jun 15]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT07352969?cond=IBI3016&viewType=Card&rank=2"},{"key":"e_1_3_4_35_1","unstructured":"ClinicalTrials.gov. A phase I clinical study to evaluate the safety tolerability pharmacokinetic characteristics and pharmacodynamic features of a single subcutaneous administration of IBI3016 in patients with mild or moderate hypertension in China [Internet]. U.S. National Library of Medicine; [cited 2026 Jun 15]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT07556796?cond=IBI3016&viewType=Card&rank=1"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/CRD.0000000000000645"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2208391"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2024.0728"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2025.6681"},{"key":"e_1_3_4_40_1","doi-asserted-by":"crossref","unstructured":"Pagidipati N Weber M Saxena M et al. KARDIA-3: Zilebesiran as add-on therapy in adults with hypertension and established cardiovascular disease or at high cardiovascular risk. Presented at the European Society of Cardiology (ESC) congress 2025. 2025. Madrid Spain. August 29-September 1.","DOI":"10.1097\/01.hjh.0001197492.36993.cc"},{"key":"e_1_3_4_41_1","unstructured":"Escardio.org. European Society of Cardiology. KARDIA-3 trial examines blood-pressure lowering effects of zilebesiran in hypertensive patients at high cardiovascular risk. [Internet]. 2025 [cited 2026 Jun 15]. Available from: https:\/\/www.escardio.org\/The-ESC\/Press-Office\/Press-releases\/KARDIA-3-trial-examines-blood-pressure-lowering-effects-of-zilebesiran-in-hypertensive-patients-at-high-cardiovascular-risk#"},{"key":"e_1_3_4_42_1","unstructured":"Roche and Alnylam advance zilebesiran into global phase iii cardiovascular outcomes trial for people with uncontrolled hypertension [Internet]. 2025. Available from: https:\/\/www.roche.com\/media\/releases\/med-cor-2025-08-30"},{"key":"e_1_3_4_43_1","unstructured":"ClinicalTrials.gov. Zenith: a phase 3 global randomized double-blind placebo-controlled study to evaluate the efficacy and safety of zilebesiran in addition to standard of Care in reducing Major adverse cardiovascular events in adult patients with hypertension not adequately controlled and with either established cardiovascular disease or high risk for cardiovascular disease [Internet]. U.S. National Library of Medicine; [cited 2026 Jun 15]. Available from: https:\/\/clinicaltrials.gov\/study\/NCT07181109"},{"key":"e_1_3_4_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00228-026-04179-4"},{"key":"e_1_3_4_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03534-y"},{"key":"e_1_3_4_46_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1258096"},{"key":"e_1_3_4_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature17946"},{"key":"e_1_3_4_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1711-4"},{"key":"e_1_3_4_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00241-0"},{"key":"e_1_3_4_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.06.012"},{"key":"e_1_3_4_51_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.120.16870"},{"key":"e_1_3_4_52_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.122.18731"},{"key":"e_1_3_4_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2026.02.5092"},{"key":"e_1_3_4_54_1","unstructured":"CRISPR Therapeutics AG. A trial evaluating safety tolerability and efficacy of CTX340 in participants with hypertension. ClinicalTrials.gov. 2026 [cited 2026 Sep 21]. Available from: https:\/\/clinicaltrialsfind.com\/trial\/NCT07758634\/"},{"key":"e_1_3_4_55_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1704154"}],"container-title":["Expert Review of Cardiovascular Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14779072.2026.2745393","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/14779072.2026.2745393","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14779072.2026.2745393","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T07:13:16Z","timestamp":1793085196000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14779072.2026.2745393"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,3]]},"references-count":53,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,3]]}},"alternative-id":["10.1080\/14779072.2026.2745393"],"URL":"https:\/\/doi.org\/10.1080\/14779072.2026.2745393","relation":{},"ISSN":["1477-9072","1744-8344"],"issn-type":[{"value":"1477-9072","type":"print"},{"value":"1744-8344","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,3]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierk20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierk20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2026-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}