{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T20:09:18Z","timestamp":1789675758633,"version":"4.0.1"},"reference-count":42,"publisher":"Informa UK Limited","issue":"17","license":[{"start":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T00:00:00Z","timestamp":1746144000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/doi.org\/10.1080\/policies-text-data-mining"}],"funder":[{"DOI":"10.13039\/100007776","name":"Deanship of Academic Research, University of Jordan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007776","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Natural Product Research"],"published-print":{"date-parts":[[2026,9,2]]},"DOI":"10.1080\/14786419.2025.2498071","type":"journal-article","created":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T07:25:54Z","timestamp":1746170754000},"page":"5109-5117","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":2,"title":["Multi-target anti-inflammatory and cytotoxic activities of flavonoids from\n                    <i>Varthemia iphionoides<\/i>\n                    Boiss. &amp; C. I. Blanche"],"prefix":"10.1080","volume":"40","author":[{"given":"Amal","family":"Al-Aboudi","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Science, The University of Jordan","place":["Amman, Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musa","family":"Abu Zarga","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Science, The University of Jordan","place":["Amman, Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafa","family":"Hourani","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, Faculty of Pharmacy, Philadelphia University","place":["Amman, Jordan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Al-Rahmoni","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Education, Al-Asmarya Islamic University","place":["Zliten, Libya"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almas","family":"Jabeen","sequence":"additional","affiliation":[{"name":"Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi","place":["Karachi, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5356-3585","authenticated-orcid":false,"given":"M. Iqbal","family":"Choudhary","sequence":"additional","affiliation":[{"name":"Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi","place":["Karachi, Pakistan"]},{"name":"H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi","place":["Karachi, Pakistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2025,5,2]]},"reference":[{"key":"e_1_3_4_2_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-815452"},{"key":"e_1_3_4_3_1","doi-asserted-by":"publisher","DOI":"10.32383\/appdr\/105777"},{"key":"e_1_3_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.2650050407"},{"key":"e_1_3_4_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2004.04.014"},{"key":"e_1_3_4_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0011-393X(97)80055-0"},{"key":"e_1_3_4_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1721727X17702151"},{"key":"e_1_3_4_8_1","volume-title":"Flora of Jordan Checklist","author":"Al-Eisawi D.","year":"2013","unstructured":"Al-Eisawi D. 2013. Flora of Jordan Checklist, Revised 1st ed. The University of Jordan Press, Amman, Jordan.","edition":"1"},{"key":"e_1_3_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2018.05.003"},{"key":"e_1_3_4_10_1","doi-asserted-by":"publisher","DOI":"10.13005\/bpj\/1985"},{"key":"e_1_3_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-017-1096-5"},{"key":"e_1_3_4_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18010322"},{"key":"e_1_3_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2008.02.038"},{"key":"e_1_3_4_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abj5070"},{"key":"e_1_3_4_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.101.12.1358"},{"key":"e_1_3_4_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-019-00637-x"},{"key":"e_1_3_4_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e318157f72d"},{"key":"e_1_3_4_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox8020035"},{"key":"e_1_3_4_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2006.08.012"},{"key":"e_1_3_4_20_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17070862"},{"key":"e_1_3_4_21_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8ra00443a"},{"key":"e_1_3_4_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2012.142"},{"key":"e_1_3_4_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-407824-6.00080-X"},{"key":"e_1_3_4_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1368"},{"key":"e_1_3_4_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13410-013-0131-5"},{"key":"e_1_3_4_26_1","doi-asserted-by":"publisher","DOI":"10.1053\/sarh.2002.37217"},{"issue":"10","key":"e_1_3_4_27_1","first-page":"1601","article-title":"Cytotoxicity of constituents from Mexican propolis against a panel of six different cancer cell lines","volume":"5","author":"Li F","year":"2010","unstructured":"Li F, Awale S, Tezuka Y, Kadota S. 2010. Cytotoxicity of constituents from Mexican propolis against a panel of six different cancer cell lines. Nat Prod Commun. 5(10):1601\u20131606.","journal-title":"Nat Prod Commun"},{"key":"e_1_3_4_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2013.03.011"},{"key":"e_1_3_4_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202305216"},{"key":"e_1_3_4_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106498"},{"key":"e_1_3_4_31_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S51250"},{"key":"e_1_3_4_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113945"},{"key":"e_1_3_4_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9995-x"},{"key":"e_1_3_4_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(95)02227-9"},{"key":"e_1_3_4_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.11.071"},{"key":"e_1_3_4_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-017-0136-y"},{"key":"e_1_3_4_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.08.047"},{"key":"e_1_3_4_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1247536"},{"key":"e_1_3_4_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.1908"},{"key":"e_1_3_4_40_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2012.749922"},{"issue":"5","key":"e_1_3_4_41_1","first-page":"649","article-title":"Nectandra amazonum-derived flavonoids as COX-1 inhibitors: in vitro and docking studies","volume":"9","author":"Vald\u00e9s-Barrera ID","year":"2014","unstructured":"Vald\u00e9s-Barrera ID, Cuca-Suarez LE, Coy-Barrera ED. 2014. Nectandra amazonum-derived flavonoids as COX-1 inhibitors: in vitro and docking studies. Nat Prod Commun. 9(5):649\u2013652.","journal-title":"Nat Prod Commun"},{"key":"e_1_3_4_42_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116601"},{"key":"e_1_3_4_43_1","doi-asserted-by":"publisher","DOI":"10.4314\/tjpr.v22i7.9"}],"container-title":["Natural Product Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14786419.2025.2498071","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/full-xml\/10.1080\/14786419.2025.2498071","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14786419.2025.2498071","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:27:39Z","timestamp":1789673259000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14786419.2025.2498071"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,2]]},"references-count":42,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9,2]]}},"alternative-id":["10.1080\/14786419.2025.2498071"],"URL":"https:\/\/doi.org\/10.1080\/14786419.2025.2498071","relation":{},"ISSN":["1478-6419","1478-6427"],"issn-type":[{"value":"1478-6419","type":"print"},{"value":"1478-6427","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,2]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=gnpl20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=gnpl20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2024-09-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}