{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T10:14:33Z","timestamp":1790763273351,"version":"4.1.0"},"reference-count":114,"publisher":"Informa UK Limited","issue":"4","funder":[{"name":"MSD Italia Srl"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Anti-infective Therapy"],"published-print":{"date-parts":[[2018,4,3]]},"DOI":"10.1080\/14787210.2018.1447381","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T13:39:27Z","timestamp":1519911567000},"page":"307-320","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":110,"title":["Ceftolozane\/tazobactam: place in therapy"],"prefix":"10.1080","volume":"16","author":[{"given":"Daniele Roberto","family":"Giacobbe","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, Ospedale Policlinico San Martino \u2013 IRCCS per l\u2019Oncologia and Department of Health Sciences, University of Genoa, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bassetti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic, Department of Medicine, University of Udine and Azienda Sanitaria Universitaria Integrata Presidio Ospedaliero Universitario Santa Maria della Misericordia, Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco Giuseppe","family":"De Rosa","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Turin, Infectious Diseases, City of Health and Sciences, Turin, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerio","family":"Del Bono","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Ospedale Policlinico San Martino \u2013 IRCCS per l\u2019Oncologia and Department of Health Sciences, University of Genoa, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo Antonio","family":"Grossi","sequence":"additional","affiliation":[{"name":"Department of Surgical and Morphological Sciences of Clinical Medicine, University of Insubria, Varese, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Menichetti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Clinic, Nuovo Santa Chiara University Hospital, Azienda Ospedaliera Universitaria Pisana, Pisa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federico","family":"Pea","sequence":"additional","affiliation":[{"name":"Institute of Clinical Pharmacology, Department of Medicine, University of Udine and Azienda Sanitaria Universitaria Integrata Presidio Ospedaliero Universitario Santa Maria della Misericordia, Udine, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gian Maria","family":"Rossolini","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy"},{"name":"Clinical Microbiology and Virology Unit, Florence Careggi University Hospital, Florence, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Tumbarello","sequence":"additional","affiliation":[{"name":"Institute of Infectious Diseases, Universit\u00e0 Cattolica del Sacro Cuore, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Viale","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Viscoli","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Ospedale Policlinico San Martino \u2013 IRCCS per l\u2019Oncologia and Department of Health Sciences, University of Genoa, Genoa, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of ISGRI-SITA (Italian Study Group on Resistant Infections of the Societ\u00e0 Italiana Terapia Antinfettiva)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2018,3,9]]},"reference":[{"key":"CIT0001","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70041-0"},{"key":"CIT0002","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.47.11.3554-3560.2003"},{"key":"CIT0003","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268810003055"},{"key":"CIT0004","unstructured":"Centers for Disease Control and Prevention. Antibiotic resistance threats in the United States. 2016. Atlanta (GA): Centers for Disease Control and Prevention. [cited 2017 Oct 30]. Available from: http:\/\/www.cdc.gov\/drugresistance\/pdf\/ar-threats-2013-508.pdf"},{"key":"CIT0005","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-017-4878-x"},{"key":"CIT0006","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-014-0596-8"},{"key":"CIT0007","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.11764"},{"key":"CIT0008","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2015.08.001"},{"key":"CIT0009","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix034"},{"key":"CIT0010","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2017.09.001"},{"key":"CIT0011","unstructured":"U.S. Food and Drug Administration. Zerbaxa \u00ae. Full prescribing information. [cited 2017 Oct 30]. Available from: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2014\/206829lbl.pdf"},{"key":"CIT0012","unstructured":"European Medicines Agency. Zerbaxa \u00ae. Annex I. Summary of product characteristics. [cited 2017 Oct 30]. Available from: http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/EPAR_-_Product_Information\/human\/003772\/WC500194595.pdf"},{"key":"CIT0013","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00296-10"},{"key":"CIT0014","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.11.074"},{"key":"CIT0015","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2007.05.019"},{"key":"CIT0016","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00680-12"},{"key":"CIT0017","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03681-14"},{"key":"CIT0018","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01104-09"},{"key":"CIT0019","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq143"},{"key":"CIT0020","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2016.02.014"},{"key":"CIT0021","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkq248"},{"key":"CIT0022","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01737-10"},{"key":"CIT0023","doi-asserted-by":"publisher","DOI":"10.1007\/s40265-013-0168-2"},{"key":"CIT0024","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00766-17"},{"key":"CIT0025","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx136"},{"key":"CIT0026","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01964-15"},{"key":"CIT0027","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01670-15"},{"key":"CIT0028","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00465-17"},{"key":"CIT0029","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx009"},{"key":"CIT0030","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjid.2017.06.008"},{"key":"CIT0031","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2017.05.025"},{"key":"CIT0032","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.06.024"},{"key":"CIT0033","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx453"},{"key":"CIT0034","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00875-17"},{"key":"CIT0035","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2010.03130.x"},{"key":"CIT0036","doi-asserted-by":"publisher","DOI":"10.1016\/j.diagmicrobio.2015.04.012"},{"key":"CIT0037","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02688-16"},{"key":"CIT0038","doi-asserted-by":"publisher","DOI":"10.1089\/mdr.2017.0266"},{"key":"CIT0039","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01117-17"},{"key":"CIT0040","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx253"},{"key":"CIT0041","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02462-13"},{"key":"CIT0042","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00825-15"},{"key":"CIT0043","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix182"},{"key":"CIT0044","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01183-17"},{"key":"CIT0045","volume-title":"M100-S27. Performance standards for antimicrobial susceptibility testing: 27th informational supplement","author":"Clinical and Laboratory Standards Institute","year":"2017"},{"key":"CIT0046","unstructured":"EUCAST. Breakpoint tables for interpretation of MICs and zone diameters. Version 7.1, 2017. [cited 2017 Oct 30]. Available from: http:\/\/www.eucast.org\/clinical_breakpoints\/"},{"key":"CIT0047","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01920-16"},{"key":"CIT0048","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1609"},{"key":"CIT0049","doi-asserted-by":"publisher","DOI":"10.1177\/1060028015593293"},{"key":"CIT0050","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.35.6.1081"},{"key":"CIT0051","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02151-13"},{"key":"CIT0052","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2015.05.003"},{"key":"CIT0053","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01449-17"},{"key":"CIT0054","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1744"},{"key":"CIT0055","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.06.005"},{"key":"CIT0056","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01590-12"},{"key":"CIT0057","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00727-15"},{"key":"CIT0058","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02513-12"},{"key":"CIT0059","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00656-13"},{"key":"CIT0060","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02635-15"},{"key":"CIT0061","doi-asserted-by":"crossref","first-page":"7272","DOI":"10.1128\/AAC.01580-16","volume":"60","author":"Melchers MJ","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"key":"CIT0062","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.395"},{"key":"CIT0063","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-016-0143-9"},{"key":"CIT0064","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.566"},{"key":"CIT0065","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dks246"},{"key":"CIT0066","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01566-16"},{"key":"CIT0067","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02310-13"},{"key":"CIT0068","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2016.07.015"},{"key":"CIT0069","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx221"},{"key":"CIT0070","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp150762"},{"key":"CIT0071","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ097"},{"key":"CIT0072","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62220-0"},{"key":"CIT0073","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00049-14"},{"key":"CIT0074","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.03074-15"},{"key":"CIT0075","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw053"},{"key":"CIT0076","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkw374"},{"key":"CIT0077","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2414-9"},{"key":"CIT0078","first-page":"900","volume":"72","author":"Kullar R","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"CIT0079","unstructured":"FDA Drug Safety Communication: FDA cautions about dose confusion and medication errors for antibacterial drug Zerbaxa (ceftolozane and tazobactam). [cited 2017 Oct 15]. Available from: https:\/\/www.fda.gov\/Drugs\/DrugSafety\/ucm445919.htm"},{"key":"CIT0080","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix014"},{"key":"CIT0081","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-017-1063-7"},{"key":"CIT0082","doi-asserted-by":"publisher","DOI":"10.1080\/14787210.2017.1380519"},{"key":"CIT0083","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00365-16"},{"key":"CIT0084","doi-asserted-by":"publisher","DOI":"10.1592\/phco.27.11.1490"},{"key":"CIT0085","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1093\/cid\/civ003","volume":"60","author":"Tamma PD","year":"2015","journal-title":"Clin Infect Dis"},{"key":"CIT0086","doi-asserted-by":"publisher","DOI":"10.1017\/ice.2015.101"},{"key":"CIT0087","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-017-2408-7"},{"key":"CIT0088","doi-asserted-by":"publisher","DOI":"10.1080\/13696998.2017.1333960"},{"key":"CIT0089","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2015.5868"},{"key":"CIT0090","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j4530"},{"key":"CIT0091","volume-title":"Annual report of the European Antimicrobial Resistance Surveillance Network (EARS-Net) 2015","author":"Antimicrobial resistance surveillance in Europe","year":"2017"},{"key":"CIT0092","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02136-16"},{"key":"CIT0093","doi-asserted-by":"publisher","DOI":"10.2217\/fmb-2017-0018"},{"key":"CIT0094","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkx172"},{"key":"CIT0095","doi-asserted-by":"publisher","DOI":"10.1038\/scsandc.2017.19"},{"key":"CIT0096","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgar.2017.02.012"},{"key":"CIT0097","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.04.001"},{"key":"CIT0098","first-page":"1402320","volume":"2017","author":"Aye C","year":"2017","journal-title":"Case Rep Infect Dis"},{"key":"CIT0099","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-217005"},{"key":"CIT0100","first-page":"224","volume":"30","author":"\u00c1lvarez Lerma F","year":"2017","journal-title":"Rev Esp Quimioter"},{"key":"CIT0101","doi-asserted-by":"publisher","DOI":"10.1177\/1060028017701938"},{"key":"CIT0102","first-page":"1262","volume":"72","author":"Sousa Dominguez A","year":"2017","journal-title":"J Antimicrob Chemother"},{"key":"CIT0103","first-page":"1520404","volume":"2016","author":"Gangcuangco LM","year":"2016","journal-title":"Case Rep Infect Dis"},{"key":"CIT0104","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-016-0944-5"},{"key":"CIT0105","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1825"},{"key":"CIT0106","first-page":"1628932","volume":"2016","author":"Jolliff JC","year":"2016","journal-title":"Case Rep Infect Dis"},{"key":"CIT0107","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001228"},{"key":"CIT0108","doi-asserted-by":"publisher","DOI":"10.1007\/s40121-016-0104-3"},{"key":"CIT0109","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/civ411"},{"key":"CIT0110","doi-asserted-by":"publisher","DOI":"10.1007\/s15010-017-1086-0"},{"key":"CIT0111","first-page":"8","volume":"23","author":"Stokem K","year":"2017","journal-title":"Respir Med Case Rep"},{"key":"CIT0112","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2017.11.003"},{"key":"CIT0113","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx163.682"},{"key":"CIT0114","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofx163.651"}],"container-title":["Expert Review of Anti-infective Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14787210.2018.1447381","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,2]],"date-time":"2025-07-02T05:33:01Z","timestamp":1751434381000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14787210.2018.1447381"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,9]]},"references-count":114,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4,3]]}},"alternative-id":["10.1080\/14787210.2018.1447381"],"URL":"https:\/\/doi.org\/10.1080\/14787210.2018.1447381","relation":{},"ISSN":["1478-7210","1744-8336"],"issn-type":[{"value":"1478-7210","type":"print"},{"value":"1744-8336","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,9]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierz20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierz20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2017-12-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-02-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}