{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:44:37Z","timestamp":1787237077331,"version":"build-2736575974"},"reference-count":90,"publisher":"Informa UK Limited","issue":"12","funder":[{"name":"the CDC"}],"content-domain":{"domain":["www.tandfonline.com"],"crossmark-restriction":true},"short-container-title":["Expert Review of Anti-infective Therapy"],"published-print":{"date-parts":[[2023,12,2]]},"DOI":"10.1080\/14787210.2023.2280214","type":"journal-article","created":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T15:23:28Z","timestamp":1699370608000},"page":"1339-1354","update-policy":"https:\/\/doi.org\/10.1080\/tandf_crossmark_01","source":"Crossref","is-referenced-by-count":35,"title":["Advantages and limitations of current diagnostic laboratory approaches in syphilis and congenital syphilis"],"prefix":"10.1080","volume":"21","author":[{"given":"Weiping","family":"Cao","sequence":"first","affiliation":[{"name":"Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phoebe G.","family":"Thorpe","sequence":"additional","affiliation":[{"name":"Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"O\u2019Callaghan","sequence":"additional","affiliation":[{"name":"Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen N.","family":"Kersh","sequence":"additional","affiliation":[{"name":"Division of STD Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"301","published-online":{"date-parts":[[2023,11,18]]},"reference":[{"key":"e_1_3_7_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00070-13"},{"key":"e_1_3_7_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.73"},{"key":"e_1_3_7_4_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.171.9.5005-5011.1989"},{"key":"e_1_3_7_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.6.2051"},{"key":"e_1_3_7_6_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.63.11.4244-4252.1995"},{"key":"e_1_3_7_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.60.3.1076-1083.1992"},{"key":"e_1_3_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2010.09.020"},{"key":"e_1_3_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.1995.tb02332.x"},{"key":"e_1_3_7_10_1","unstructured":"Tudor ME Al Aboud AM Leslie SW et al. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan [Updated 2023 May 30]. Available from: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK534780\/"},{"key":"e_1_3_7_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.11.1510"},{"key":"e_1_3_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2013.08.005"},{"key":"e_1_3_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa176"},{"key":"e_1_3_7_14_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7004a1"},{"key":"e_1_3_7_15_1","unstructured":"Centers for Disease Control and Prevention. Sexually transmitted infections prevalence incidence and cost estimates in the United States. (Ed.^(Eds). 2023."},{"key":"e_1_3_7_16_1","unstructured":"Organization WH. Syphilis. (Ed.^(Eds). 2023."},{"key":"e_1_3_7_17_1","unstructured":"Centers for Disease Control and Prevention. CDC call to action: Let\u2019s work together to stem the tide of rising syphilis in the US. (Ed.^(Eds). 2017."},{"key":"e_1_3_7_18_1","unstructured":"Organization WH. Global health sector strategy on sexually transmitted infections 2016-2021. (Ed.^(Eds). 2016."},{"key":"e_1_3_7_19_1","volume-title":"Sexually Transmitted Infections National Strategic Plan for the United States: 2021\u20132025","author":"U.S. Department of Health and Human Services","year":"2020","unstructured":"U.S. Department of Health and Human Services. Sexually Transmitted Infections National Strategic Plan for the United States: 2021\u20132025. Washington (DC); 2020."},{"key":"e_1_3_7_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/1178633719883282"},{"key":"e_1_3_7_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000842"},{"key":"e_1_3_7_22_1","volume-title":"ASM Org","author":"Hemarajata P","year":"2020","unstructured":"Hemarajata P. A Brief History of Laboratory Diagnostics for Syphilis. ASM Org. 2020 Jan 6.https:\/\/asm.org\/Articles\/2020\/January\/A-Brief-History-of-Laboratory-Diagnostics-for-Syph"},{"key":"e_1_3_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2019.02.074"},{"key":"e_1_3_7_24_1","volume-title":"A manual of tests for syphilis","author":"Larsen SA","year":"1998","unstructured":"Larsen SA, Pope V, Johnson R, et al. A manual of tests for syphilis. Washington (DC): Association of Public Health Laboratories; 1998."},{"key":"e_1_3_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eimce.2021.10.001"},{"key":"e_1_3_7_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007435-198707000-00007"},{"key":"e_1_3_7_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.22.2.241-244.1985"},{"key":"e_1_3_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700888"},{"key":"e_1_3_7_29_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1991.32.4.335"},{"key":"e_1_3_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(87)55023-6"},{"key":"e_1_3_7_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.4.1173"},{"key":"e_1_3_7_32_1","doi-asserted-by":"publisher","DOI":"10.1258\/095646207782716901"},{"key":"e_1_3_7_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41426-018-0085-2"},{"key":"e_1_3_7_34_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1678-9946202264075"},{"key":"e_1_3_7_35_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.00112-23"},{"key":"e_1_3_7_36_1","volume-title":"Guidelines for the management of symptomatic sexually transmitted infections","author":"Organization WH","year":"2021","unstructured":"Organization WH. Genital ucler disease syndrome. Guidelines for the management of symptomatic sexually transmitted infections. Geneva: World Health Organization; 2021."},{"key":"e_1_3_7_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2021-055081"},{"key":"e_1_3_7_38_1","unstructured":"Centers for Disease Control and Prevention. MPOX clinical recognition. (Ed.^(Eds). 2023"},{"key":"e_1_3_7_39_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.24.3.713-719.1979"},{"key":"e_1_3_7_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiy241"},{"key":"e_1_3_7_41_1","doi-asserted-by":"publisher","DOI":"10.1177\/00333549231176007"},{"key":"e_1_3_7_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000541"},{"key":"e_1_3_7_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/antib5020015"},{"key":"e_1_3_7_44_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.62.5.388"},{"key":"e_1_3_7_45_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.014175"},{"key":"e_1_3_7_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02032099"},{"key":"e_1_3_7_47_1","unstructured":"FDA. Possible false RPR reactivity with BioPlex 2200 syphilis total & RPR test kit following a COVID-19 Vaccine - letter to clinical laboratory staff and Health care providers. (Ed.^(Eds). 2021."},{"key":"e_1_3_7_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciu325"},{"key":"e_1_3_7_49_1","doi-asserted-by":"publisher","DOI":"10.1071\/SH11156"},{"key":"e_1_3_7_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa306"},{"key":"e_1_3_7_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.00168-23"},{"key":"e_1_3_7_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa349"},{"key":"e_1_3_7_53_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2019-035838"},{"key":"e_1_3_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2013.03.011"},{"key":"e_1_3_7_55_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00100-21"},{"key":"e_1_3_7_56_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2508.181690"},{"key":"e_1_3_7_57_1","unstructured":"Trinity Biotech. Syphilis Health check. (Ed.^(Eds). 2017."},{"key":"e_1_3_7_58_1","unstructured":"Diagnostics C. DPP\u00ae HIV-Syphilis. (Ed.^(Eds)."},{"key":"e_1_3_7_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19138172"},{"key":"e_1_3_7_60_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02642-21"},{"key":"e_1_3_7_61_1","unstructured":"Chembio Diagnostics I. Chembio Diagnostics awarded $3.2 million contract from the CDC for development and clinical validation of dual-path platform syphilis screen & confirm assay. (Ed.^(Eds)). 2022."},{"key":"e_1_3_7_62_1","doi-asserted-by":"publisher","DOI":"10.1128\/CVI.00681-14"},{"key":"e_1_3_7_63_1","unstructured":"Association of Public Health Laboratories. Suggested reporting language for syphilis serology testing. (Ed.^(Eds). 2020."},{"key":"e_1_3_7_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.05636-11"},{"key":"e_1_3_7_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plabm.2017.04.007"},{"issue":"5","key":"e_1_3_7_66_1","first-page":"133","article-title":"Discordant results from reverse sequence syphilis screening\u2013five laboratories, United States, 2006-2010","volume":"60","author":"Centers for Disease Control","year":"2011","unstructured":"Centers for Disease Control. Discordant results from reverse sequence syphilis screening\u2013five laboratories, United States, 2006-2010. MMWR Morb Mortal Wkly Rep. 2011;60(5):133\u2013137.","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_3_7_67_1","doi-asserted-by":"publisher","DOI":"10.5858\/2016-0110-CP"},{"key":"e_1_3_7_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciaa307"},{"key":"e_1_3_7_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqw182"},{"key":"e_1_3_7_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005758"},{"key":"e_1_3_7_71_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00310-17"},{"key":"e_1_3_7_72_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2018-053666"},{"key":"e_1_3_7_73_1","unstructured":"Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance (Ed.^(Eds). 2021."},{"key":"e_1_3_7_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.29.8.1711-1718.1991"},{"key":"e_1_3_7_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(84)91993-7"},{"key":"e_1_3_7_76_1","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.1.1.32-37.1994"},{"key":"e_1_3_7_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.1972.tb00496.x"},{"key":"e_1_3_7_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.11.659"},{"key":"e_1_3_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.11.035"},{"key":"e_1_3_7_80_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2022.15322"},{"key":"e_1_3_7_81_1","unstructured":"Force USPST. Syphilis infection in nonpregnant adolescents and adults: screening. (Ed.^(Eds). [2022 Sep 27]."},{"key":"e_1_3_7_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cit665"},{"key":"e_1_3_7_83_1","unstructured":"Physicians AAoF. Clinical preventive service recommendation syphilis. (Ed.^(Eds) (2023)"},{"key":"e_1_3_7_84_1","unstructured":"Centers for Disease Control and Prevention. Screening recommendations and considerations referenced in treatment guidelines and original sources. (Ed.^(Eds). 2022."},{"key":"e_1_3_7_85_1","unstructured":"Centers for Disease Control and Prevention. Persons in correctional facilities. (Ed.^(Eds). 2022."},{"key":"e_1_3_7_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2017.07.024"},{"key":"e_1_3_7_87_1","doi-asserted-by":"publisher","DOI":"10.1097\/OLQ.0000000000000638"},{"key":"e_1_3_7_88_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix326"},{"key":"e_1_3_7_89_1","doi-asserted-by":"publisher","DOI":"10.1136\/sti.2006.024265"},{"key":"e_1_3_7_90_1","unstructured":"World Health Organization. Point-of-care tests for sexually transmitted infections: target product profiles. (Ed.^(Eds). [2023 Jul 18]."},{"key":"e_1_3_7_91_1","doi-asserted-by":"publisher","DOI":"10.1136\/sextrans-2019-054358"}],"container-title":["Expert Review of Anti-infective Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.tandfonline.com\/doi\/pdf\/10.1080\/14787210.2023.2280214","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T00:01:04Z","timestamp":1730764864000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/14787210.2023.2280214"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,18]]},"references-count":90,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2023,12,2]]}},"alternative-id":["10.1080\/14787210.2023.2280214"],"URL":"https:\/\/doi.org\/10.1080\/14787210.2023.2280214","relation":{},"ISSN":["1478-7210","1744-8336"],"issn-type":[{"value":"1478-7210","type":"print"},{"value":"1744-8336","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,18]]},"assertion":[{"value":"The publishing and review policy for this title is described in its Aims & Scope.","order":1,"name":"peerreview_statement","label":"Peer Review Statement"},{"value":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierz20","URL":"http:\/\/www.tandfonline.com\/action\/journalInformation?show=aimsScope&journalCode=ierz20","order":2,"name":"aims_and_scope_url","label":"Aim & Scope"},{"value":"2023-09-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}