{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:19:11Z","timestamp":1790522351365,"version":"4.1.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2008,1,3]],"date-time":"2008-01-03T00:00:00Z","timestamp":1199318400000},"content-version":"vor","delay-in-days":1038,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Human T cell leukemia virus type I (HTLV\u2010I) is the causative agent of a fatal malignancy known as adult T cell leukemia (ATL). The HTLV\u2010I Tax protein is thought to play a significant role in the initiation and pathogenesis of HTLV\u2010I\u2010mediated disease. Tax is a potent oncogene that deregulates cellular gene expression by persistently activating signaling pathways such as NF\u2010\u03baB. Tax activation of NF\u2010\u03baB is critical for the immortalization and survival of HTLV\u2010I\u2010infected T cells. In this review, we describe recent insights into the mechanisms employed by Tax to activate the canonical and noncanonical NF\u2010\u03baB signaling pathways. The adaptor function of Tax appears to be a common and important mechanism for the pathological activation of both NF\u2010\u03baB pathways.\nIUBMB Life, 57: 83\u201091, 2005<\/jats:p>","DOI":"10.1080\/15216540500078715","type":"journal-article","created":{"date-parts":[[2006,2,21]],"date-time":"2006-02-21T16:53:13Z","timestamp":1140540793000},"page":"83-91","source":"Crossref","is-referenced-by-count":43,"title":["Mechanisms of Persistent NF\u2010\u03baB Activation by HTLV\u2010I Tax"],"prefix":"10.1002","volume":"57","author":[{"given":"Edward W.","family":"Harhaj","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole S.","family":"Harhaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2008,1,3]]},"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F15216540500078715","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/15216540500078715","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T04:33:49Z","timestamp":1700195629000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1080\/15216540500078715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.1080\/15216540500078715"],"URL":"https:\/\/doi.org\/10.1080\/15216540500078715","archive":["Portico"],"relation":{},"ISSN":["1521-6543","1521-6551"],"issn-type":[{"value":"1521-6543","type":"print"},{"value":"1521-6551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}