{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:41:56Z","timestamp":1773769316176,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2008,1,3]],"date-time":"2008-01-03T00:00:00Z","timestamp":1199318400000},"content-version":"vor","delay-in-days":885,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IUBMB Life"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Leptin, a pleiotropic cytokine that regulates food intake and metabolic and endocrine responses, has emerged recently as an important regulator of mucosal inflammatory responses to bacterial infection. In this study, we report that in sublingual salivary gland acinar cells leptin plays a role in the suppression of up\u2010regulation in endothelin\u20101 (ET\u20101), induced by the LPS of a periodontopathic bacterium P. gingivalis. We show that P. gingivalis LPS detrimental effect on salivary mucin synthesis, associated with up\u2010regulation (3.9\u2010fold) in ET\u20101 generation and the enhancement (3.2\u2010fold) in endothelin\u2010converting enzyme\u20101 (ECE\u20101) activity, was subject to a dose\u2010dependent suppression by leptin. The impedance by leptin of the LPS inhibitory effect on mucin synthesis was blocked by wortmannin, an inhibitor of PI3K, as well as by ERK inhibitor, PD98059. However, while the blockade of ERK led also to amplification in the impedance by leptin of the LPS\u2010induced expression of ECE\u20101 and ET\u20101, the effect was not observed in the presence of wortmannin. The findings are the first to demonstrate that leptin counters the pathological consequences of P. gingivalis infection on the synthesis of salivary mucin through the involvement in signaling events of PI3K and ERK pathways. We also show that the ERK cascade represents a critical signaling target for leptin in the LPS\u2010induced up\u2010regulation in ET\u20101.\nIUBMB Life, 57: 591\u2010595, 2005<\/jats:p>","DOI":"10.1080\/15216540500215598","type":"journal-article","created":{"date-parts":[[2005,9,6]],"date-time":"2005-09-06T17:52:56Z","timestamp":1126029176000},"page":"591-595","source":"Crossref","is-referenced-by-count":7,"title":["Role of Leptin in Modulation of Porphyromonas gingivalis Lipopolysaccharide\u2010induced Up\u2010regulation of Endothelin\u20101 in Salivary Gland Acinar Cells"],"prefix":"10.1002","volume":"57","author":[{"given":"Bronislaw L.","family":"Slomiany","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalia","family":"Slomiany","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,3]]},"container-title":["IUBMB Life"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1080%2F15216540500215598","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/pdf\/10.1080\/15216540500215598","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T04:32:04Z","timestamp":1700195524000},"score":1,"resource":{"primary":{"URL":"https:\/\/iubmb.onlinelibrary.wiley.com\/doi\/10.1080\/15216540500215598"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1080\/15216540500215598"],"URL":"https:\/\/doi.org\/10.1080\/15216540500215598","archive":["Portico"],"relation":{},"ISSN":["1521-6543","1521-6551"],"issn-type":[{"value":"1521-6543","type":"print"},{"value":"1521-6551","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8]]}}}